The HuGE Reviews archive is organized by topic category, with the most recent review listed first under each heading. As a service to our readers, the HuGENet™ staff has included other systematic reviews found in the literature where authors have taken a quantitative approach in their review of epidemiologic evidence between genes and diseases. A link to a list of those systematic reviews can be found at the end of each topic category.
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Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis.
(February 2008) |
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The E-cadherin Gene Polymorphism 160C->A and Cancer Risk: A HuGE Review and Meta-Analysis of 26 Case-Control Studies.
(January 2008) |
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Genetic variants of Glutathione S-Transferase as possible risk factors for hepatocellular carcinoma: A HuGE systematic review and meta-Analysis.
(December 2007) |
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Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Gastric Cancer Risk: A Huge-GSEC Review
(December 2007) |
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A Meta-Analysis of the Association of N-Acetyltransferase 2 Gene (NAT2)
Variants with Breast Cancer
(August 2007) |
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Joint Effects of the N-Acetyltransferase 1 and 2 (NAT1 and NAT2) Genes and Smoking on Bladder Carcinogenesis: A Literature-based Systematic HuGE Review and Evidence Synthesis
(August 2007) |
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Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review
(April 2007) |
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Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis
(February 2007) |
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Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer
(October 2006)
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Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A Huge-GSEC Review
(September 2006) |
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Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and
Endometrial Cancer: A HuGE Review
(July 2006) |
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XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer
(May 2006) |
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Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review
(November 2005) |
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NQO1, MPO, and the
Risk of Lung Cancer
Chikako Kiyohara, PhD et al.
(October 2005) |
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Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer
(May 2005) |
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HFE Gene Mutations in Susceptibility to Childhood Leukemia
(March 2005) |
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ERCC2 /XPD Gene Polymorphisms and Lung Cancer
(January 2005) |
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EPHX1 Polymorphisms and the Risk of Lung Cancer
Chikako Kiyohara, et al.
(January 2005) |
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CYP3A4 Polymorphisms—Potential Risk Factors for Breast and Prostate Cancer
(October 2004) |
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Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia
(March 2004) |
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Ovarian Cancer and Polymorphisms in the Androgen and Progesterone Receptor Genes
(February 2004) |
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Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer
(January 2004) |
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Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency
(2004) *Link to HuGE Fact Sheet |
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5,10-Methylenetetrahydrofolate Reductase Polymorphismsand Leukemia Risk
(April 2003) |
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Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer
(November 2002) *Link to HuGE Fact Sheet |
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Glutathione S-Transferase Polymorphisms and Risk of Ovarian Cancer(August 2002) |
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Pooled Analysis of Meta-Analysis GSTM1 and Bladder Cancer
(July 2002) |
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Androgen Receptor (AR) CAG Repeats and Prostate Cancer
(May 2002) *Link to HuGE Fact Sheet |
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GSTM1, GSTT1 and Risk of Squamous Cell Carcinoma of the Head and Neck(2001) *Link to HuGE Fact Sheet |
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N-Acetyltransferase Polymorphisms and Colorectal Cancer
(May 2000) |
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Glutathione S Transferase Polymorphisms and Colorectal Cancer
(January 2000) |
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NF1 Gene and Neurofibromatosis Type 1
(January 2000) |
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Other Systematic Reviews |
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Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies
(August 2006) |
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CTLA4 Polymorphisms and Type 1 Diabetes Mellitus: A HuGE Gene-disease Association Review
(July 2005) |
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Systematic Review and Meta-Analysis of the Association between ß2-Adrenoceptor Polymorphisms and Asthma
(March 2005) |
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Genetics of leptin and obesity
(October 2004) |
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Familial Hypercholesterolemia and Coronary Heart Disease: A HuGE Association Review
(September 2004) |
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Familial Hypercholesterolemia, Peripheral Arterial Disease, and Stroke: A HuGE Minireview
(September 2004) |
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Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review
(September 2004) |
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Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency
(2004) *Link to HuGE Fact Sheet |
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HFE Gene and Hereditary Hemochromatosis
(2001) |
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HLA-DQ Locus of the Human Leukocyte Antigen Complex and Type 1 Diabetes Mellitus
(May 2000) |
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Medium Chain Acyl-coA Dehydrogenase (MCAD) Deficiency
(December 1999)
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Link to
Other Systematic Reviews |
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Sickle Hemoglobin (Hb S) Allele and Sickle Cell Disease
(May 2000) |
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Other Systematic Reviews |
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Association study between interleukin 1β gene
and epileptic disorders: a HuGe review and
meta-analysis
(February 2008) |
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Meta-Analysis of the Association of the Taq1A Polymorphism with the Risk of Alcohol Dependency: A HuGE Gene-Disease Association Review.
(November 2007) |
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Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: A HuGE review and meta-analysis
(January 2007) |
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Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review
(October 2006) |
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Other Systematic Reviews |
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HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review
(March 2007) |
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Association between Apolipoprotein E Polymorphisms and Age-related Macular Degeneration
(August 2006) |
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Meta-Analysis of the Association of the Cathepsin D Ala224Val Gene Polymorphism with the Risk of Alzheimer's Disease
(2004) |
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GJB2 (Connexin 26)
Variants and Nonsyndromic Sensorineural Hearing
Loss (August 2002) |
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Other Systematic Reviews |
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Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis
(July 2007) |
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Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence
(May 2007) |
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Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease
(September 2006) |
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Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism
(July 2006) |
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The long QT syndrome family of cardiac ion channelopathies
(March 2006) |
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CYP2C9
Gene Variants and Clinical Outcomes of Warfarin-Treated
Patients
(February 2005) |
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Familial Hypercholesterolemia and Coronary Heart Disease: A HuGE Association Review
(September 2004) |
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Familial Hypercholesterolemia, Peripheral Arterial Disease, and Stroke: A HuGE Minireview
(September 2004) |
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Apolipoprotein E Polymorphism and Cardiovascular Disease
(March 2002) *Link to HuGE Fact Sheet |
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Link to
Other Systematic Reviews |
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Other Systematic Reviews |
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NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis
Franceschini, Nora et al.
(February 2006) |
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Other Systematic Reviews |
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Genetic Risk Factors for Placental Abruption: A HuGE Review and Meta-Analysis.
(March 2008) |
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Alcohol dehydrogenase 1B genotype and fetal alcohol
syndrome: a HuGE minireview
Ridgely Fisk Green, PhD; Joan Marilyn Stoler, MD
(July 2007) |
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Genetic variation associated with preterm birth
(December 2005) |
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Link to
Other Systematic Reviews |
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Association between the Transforming Growth Factor Alpha Gene and
Nonsyndromic Oral Clefts
(March 2006) |
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FMR1 and the Fragile X Syndrome
(October 2001) *Link to HuGE Fact Sheet |
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5,10-Methylenetetrahydrofolate Reductase (MTHFR) Gene Variants and Congenital Anomalies
(August 1999) |
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Link to
Other Systematic Reviews |
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Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis
(February 2005) |
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Molecular epidemiology of vitamin D receptor gene variants
(February 2000) |
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Link to
Other Systematic Reviews |
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CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors
(October 2004) |
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Link to
Other Systematic Reviews |
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HLA-DPB1 and Chronic Beryllium Disease
(March 2003) *Link to HuGE Fact Sheet |
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NAD(P)H: Quinone Oxidoreductase (NQO1) Polymorphism, Exposure to Benzene, and Predisposition to Disease
(April 2002) |
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d-Aminolevulinic Acid Dehydratase (ALAD) Genotype and Lead Toxicity
(July 2001) *Link to HuGE Fact Sheet |
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