Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 

HugeNet™

Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 27, 2008
Volume 20, No. 13

Return to Weekly Update

Many of the news links published in o-ur Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

Comparative analysis of common CFTR polymorphisms poly-T, TG-repeats and M470V in a healthy Chinese population
Huang Q, et al.
World J Gastroenterol 2008 Mar;14(12):1925-30

 

Infectious and Parasitic Diseases

HLA Class I-Restricted T Cell Responses May Contribute to the Control of HIV Infection, but Such Responses are Not Always Necessary for Long-term Virus Control
Emu B, et al.
J Virol 2008 Mar

 

Neoplasms

Prevalence of BER gene polymorphisms in sporadic breast cancer
Ali MF, et al.
Oncol Rep 2008 Apr;19(4):1033-8

Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth  factor genes
Chia VM, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):721-6

Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer
Ye Y, et al.
Cancer 2008 Mar

Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis
Zhang J, et al.
J Hum Genet 2008 Mar

A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer
Yaspan BL, et al.
Hum Genet 2008 Mar

UGT1A1 Genetic Polymorphisms, Endogenous Estrogen Exposure, Soy Food Intake, and  Endometrial Cancer Risk
Deming SL, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):563-70

Mismatch Repair Gene MSH3 Polymorphism is Associated With the Risk of Sporadic Prostate Cancer
Hirata H, et al.
J Urol 2008 Mar

Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer
Beebe-Dimmer JL, et al.
Int J Cancer 2008 Mar

Oncogenic virus-associated neoplasia: A role for cyclin D1 genotypes influencing  the age of onset of disease?
Catarino R, et al.
Biochem Biophys Res Commun 2008 Mar

Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk  of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma
Ferguson HR, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):727-31

DNA Repair Gene XPD Polymorphisms and Cancer Risk: A Meta-analysis Based on 56 Case-Control Studies
Wang F, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):507-17

Analysis of GADD45A sequence variations in French Canadian families with high risk of breast cancer
Desjardins S, et al.
J Hum Genet 2008 Mar

Association of genetic variants at 8q24 with breast cancer risk
Fletcher O, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):702-5

The role of MTHFR gene in multiple myeloma
Zintzaras E, et al.
J Hum Genet 2008 Mar

Selected class I and class II HLA alleles and haplotypes and risk of high-grade cervical intraepithelial neoplasia
Ades S, et al.
Int J Cancer 2008 Mar

Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans
Sun J, et al.
Prostate 2008 Mar

Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine  synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population
Shekari M, et al.
Arch Gynecol Obstet 2008 Mar

Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index
Xing LL, et al.
World J Gastroenterol 2008 Mar;14(11):1785-9

Prognostic role of p53 codon 72 polymorphism in gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy
Huang ZH, et al.
J Cancer Res Clin Oncol 2008 Mar

No Association between hOGG1, XRCC1, and XPD Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, or Esophageal Adenocarcinoma: Results from the  Factors Influencing the Barrett's Adenocarcinoma Relationship Case-Control Study
Ferguson HR, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):736-9

CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal  cancer in the United Kingdom population
Pittman AM, et al.
Br J Cancer 2008 Mar

Association study of TP53 polymorphisms with lung cancer in a Korean population
Jung HY, et al.
J Hum Genet 2008 Mar

Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with  refractory advanced colorectal cancer
Graziano F, et al.
J Clin Oncol 2008 Mar;26(9):1427-34

NAT2*7 Allele Is a Potential Risk Factor for Adult Brain Tumors in Taiwanese Population
Liu HE, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):661-5

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Antoniou AC, et al.
Am J Hum Genet 2008 Mar

No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients
Cho YG, et al.
Neoplasma 2008;55(3):256-60

 

Endocrine, Nutritional and Metabolic Diseases

Constitutional delay of growth and puberty is not commonly associated with mutations in the acid labile subunit gene
Banerjee I, et al.
Eur J Endocrinol 2008 Apr;158(4):473-7

Association of Peroxisome Proliferator-Activated Receptorgamma Gene Pro12Ala and  C161T Polymorphisms With Metabolic Syndrome
Dongxia L, et al.
Circ J 2008 Apr;72(4):551-7

Cutaneous Microvascular Dysfunction Is Associated With Human Leukocyte Antigen-DQ in Youths With Type 1 Diabetes
Odermarsky M, et al.
Pediatr Res 2008 Apr;63(4):420-2

ACTH Receptor Promoter Polymorphism Associates With Severity of Premature Adrenarche and Modulates Hypothalamo-Pituitary-Adrenal Axis in Children
Lappalainen S, et al.
Pediatr Res 2008 Apr;63(4):410-4

Genotype-phenotype correlation in children with familial Mediterranean fever in a Turkish population
Dusunsel R, et al.
Pediatr Int 2008 Apr;50(2):208-12

Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population
Kostrzewa G, et al.
Mol Genet Metab 2008 Mar

The Role of Major Histocompatibility Complex Alleles in the Susceptibility of Brazilian Patients to Develop the Myogenic Type of Graves' Orbitopathy
Akaishi PM, et al.
Thyroid 2008 Mar

Gilbert's Syndrome and Irinotecan Toxicity: Combination with UDP-Glucuronosyltransferase 1A7 Variants Increases Risk
Lankisch TO, et al.
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):695-701

Polymorphisms in metallothionein-1 and 2 genes associated with the risk of type 2 diabetes mellitus and its complications
Yang L, et al.
Am J Physiol Endocrinol Metab 2008 Mar

Common Variations in Perilipin Gene, Central Obesity, and Risk of Type 2 Diabetes in US Women
Qi L, et al.
Obesity (Silver Spring) 2008 Mar

Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth with Type 1 Diabetes
Vehik K, et al.
Diabetes Care 2008 Mar

 

Mental Disorders

Serotonin transporter gene and response to lithium augmentation in depression
Stamm TJ, et al.
Psychiatr Genet 2008 Apr;18(2):92-7

Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders
Hettema JM, et al.
Psychiatr Genet 2008 Apr;18(2):73-9

Effects of GABRA2 Variation on Physiological, Psychomotor and Subjective Responses in the Alcohol Challenge Twin Study
Lind PA, et al.
Twin Res Hum Genet 2008 Apr;11(2):174-82

Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder
Lohoff FW, et al.
Psychiatr Genet 2008 Apr;18(2):53-8

Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
Koller G, et al.
Psychiatr Genet 2008 Apr;18(2):59-63

Association study of serotonin system genes in childhood-onset mood disorder
Shaikh SA, et al.
Psychiatr Genet 2008 Apr;18(2):47-52

Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers
Katsuyama H, et al.
Int J Mol Med 2008 Apr;21(4):499-505

Significant Association of ANKK1 and Detection of a Functional Polymorphism with  Nicotine Dependence in an African-American Sample
Huang W, et al.
Neuropsychopharmacology 2008 Mar

DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents
Bombin I, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Association study of dopamine D2, D4 receptor gene, GABAA receptor beta subunit gene, serotonin transporter gene polymorphism with children of alcoholics in Korea: A preliminary study
Namkoong K, et al.
Alcohol 2008 Mar;42(2):77-81

Association of PTPRB gene polymorphism with drug addiction
Ishiguro H, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Absence of the 7-repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls
Johnson KA, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
Binder EB, et al.
JAMA 2008 Mar;299(11):1291-305

 

Diseases of the Nervous System and Sense Organs

Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort
Uthra S, et al.
Ophthalmic Genet 2008 Mar;29(1):11-5

Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy
Bovo G, et al.
Neurosci Lett 2008 Mar

Interleukin-10 (IL10) and tumor necrosis factor alpha (TNF) gene polymorphisms in Parkinson's disease patients
Bialecka M, et al.
Parkinsonism Relat Disord 2008 Mar

Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease
Lautier C, et al.
Am J Hum Genet 2008 Mar

IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
Weber F, et al.
Genes Immun 2008 Mar

Single-nucleotide polymorphisms (SNPs) and haplotype analysis in vascular endothelial growth factor (VEGF) gene in the patients with Parkinson disease and  lung cancer
Kim JS, et al.
Arch Gerontol Geriatr 2008 Mar

Association study of the HLA-A2 allele in Italian Alzheimer disease patients
Guerini FR, et al.
Neurobiol Aging 2008 Mar

Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series  of parkinsonian syndromes and frontotemporal lobar degeneration
Gaig C, et al.
J Neurol Sci 2008 Mar

Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism
Kim SJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study
Arias-Vasquez A, et al.
J Neurol 2008 Mar

DNMBP is genetically associated with Alzheimer dementia in the Belgian population
Bettens K, et al.
Neurobiol Aging 2008 Mar

Genotype-phenotype correlations for exudative Age-related Macular Degeneration associated with homozygous HTRA1 and CFH genotypes
Leveziel N, et al.
Invest Ophthalmol Vis Sci 2008 Mar

Estrogen Receptor Alpha and Matrix Metalloproteinase 2 Polymorphisms and Age-related Maculopathy in Older Women
Seitzman RL, et al.
Am J Epidemiol 2008 Mar

 

Diseases of the Circulatory System

Association of Human SCN5A Polymorphisms With Idiopathic Ventricular Arrhythmia in a Chinese Han Cohort
Fang DH, et al.
Circ J 2008 Apr;72(4):592-7

Polymorphisms associated with cholesterol and risk of cardiovascular events
Kathiresan S, et al.
N Engl J Med 2008 Mar;358(12):1240-9

Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction
Guxens M, et al.
Rev Esp Cardiol 2008 Mar;61(3):269-75

Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease
Schunkert H, et al.
Circulation 2008 Mar

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
Bhattacharyya T, et al.
JAMA 2008 Mar;299(11):1265-76

Polymorphisms in the Lymphotoxin Alpha Gene and the Risk of Ischemic Stroke in the Japanese Population. The Fukuoka Stroke Registry and the Hisayama Study
Hagiwara N, et al.
Cerebrovasc Dis 2008 Mar;25(5):417-22

The -8 UTR C/G polymorphism of PSMA6 gene is associated with susceptibility to myocardial infarction in type 2 diabetic patients
Barbieri M, et al.
Atherosclerosis 2008 Mar

Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers of BMPR2 Mutation
Sztrymf B, et al.
Am J Respir Crit Care Med 2008 Mar

Genetic Variants of Tumor Necrosis Factor Superfamily, Member 4 (TNFSF4), and Risk of Incident Atherothrombosis and Venous Thromboembolism
Malarstig A, et al.
Clin Chem 2008 Mar

Gene variants associated with deep vein thrombosis
Bezemer ID, et al.
JAMA 2008 Mar;299(11):1306-14

 

Diseases of the Respiratory System

Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD
He JQ, et al.
Eur Respir J 2008 Mar

 

Diseases of the Digestive System

PAX9 polymorphisms and susceptibility to sporadic tooth agenesis: a case-control  study in southeast China
Pan Y, et al.
Eur J Oral Sci 2008 Apr;116(2):98-103

Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population
Takeuchi-Hatanaka K, et al.
J Clin Periodontol 2008 Apr;35(4):317-23

Association of Inflammatory Cytokine Gene Polymorphisms with Platelet Recovery in Idiopathic Thrombocytopenic Purpura Patients after the Eradication of Helicobacter pylori
Suzuki T, et al.
Digestion 2008 Mar;77(2):73-8

 

Complications of Pregnancy, Childbirth, and the Puerperium

Paternal Contribution of H L A-G*0106 Significantly Increases Risk for Pre-Eclampsia in Multigravid Pregnancies
Tan CY, et al.
Mol Hum Reprod 2008 Mar

 

Diseases of the Skin and Subcutaneous Tissue

The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis
Weger W, et al.
Exp Dermatol 2008 Mar

HLA-DM polymorphism and risk of trichloroethylene induced medicamentosa-like dermatitis
Yue F, et al.
Biomed Environ Sci 2007 Dec;20(6):506-11

 

Diseases of the Musculoskeletal System and Connective Tissue

Genetic association study of polymorphisms in the catalase gene with the risk of  osteonecrosis of the femoral head in the Korean population
Kim TH, et al.
Osteoarthritis Cartilage 2008 Mar

Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor {beta}1 gene
Chang SJ, et al.
Rheumatology (Oxford) 2008 Mar

Genetic Background of Nontraumatic Osteonecrosis of the Femoral Head in the Korean Population
Chang JD, et al.
Clin Orthop Relat Res 2008 Mar

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
van Meurs JB, et al.
JAMA 2008 Mar;299(11):1277-90

Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity
Ronkainen PH, et al.
PLoS ONE 2008;3(3):e1819

 

Congenital Anomalies

Study of the poliovirus receptor related-1 gene in Thai patients with non-syndromic cleft lip with or without cleft palate
Tongkobpetch S, et al.
Int J Oral Maxillofac Surg 2008 Mar

Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations
Sull JW, et al.
Genet Epidemiol 2008 Mar

 

Injury and Poisoning

Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls
Posthumus M, et al.
J Sci Med Sport 2008 Mar

 

For more information on HuGE, please visit the HuGENet™ home page

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only.
Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

Page last reviewed: March 27, 2008 (archived document)
Content Source: National Office of Public Health Genomics