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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 30, 2007
Volume 19, No. 9

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

H pylori seropositivity and cytokine gene polymorphisms
Saijo Y, et al.
World J Gastroenterol 2007 Sep;13(33):4445-51

Association of TLR4 Polymorphisms with Symptomatic Respiratory Syncytial Virus Infection in High-Risk Infants and Young Children
Awomoyi AA, et al.
J Immunol 2007 Sep;179(5):3171-7

Selective pressures of HLA genotypes and antiviral therapy on HIV-1 sequence mutation at a population level
Ahlenstiel G, et al.
Clin Vaccine Immunol 2007 Aug

Association between toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus
Eid AJ, et al.
Transplantation 2007 Aug;84(4):511-6

 

Neoplasms

Effects of interleukin-10 gene polymorphism on the development of gastric cancer  and peptic ulcer in Japanese subjects
Sugimoto M, et al.
J Gastroenterol Hepatol 2007 Sep;22(9):1443-9

The Prevalence and Prognostic Value of BRAF Mutation in Thyroid Cancer
Kebebew E, et al.
Ann Surg 2007 Sep;246(3):466-71

Association of Polymorphism in MDM-2 and p53 Genes with Breast Cancer Risk in Indian Women
Singh V, et al.
Ann Epidemiol 2007 Aug

Glutathione S-transferases pi1, alpha1 and micro3 genetic polymorphisms and the risk of hepatocellular carcinoma in humans
Ladero JM, et al.
Pharmacogenomics 2007 Aug;8(8):895-9

Germline Polymorphisms in EGFR and Survival in Patients With Lung Cancer Receiving Gefitinib
Gregorc V, et al.
Clin Pharmacol Ther 2007 Aug

Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma
Wei YS, et al.
Clin Immunol 2007 Aug

Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma
Akbari MR, et al.
Oncogene 2007 Aug

IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African Americans
Hernandez W, et al.
Carcinogenesis 2007 Aug

Single Nucleotide Polymorphisms in the NOD2/CARD15 Gene Are Associated With an Increased Risk of Relapse and Death for Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation With Unrelated Donors
Mayor NP, et al.
J Clin Oncol 2007 Aug

Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)
McGrath M, et al.
Cancer Causes Control 2007 Aug

LKB1 gene mutations in Japanese lung cancer patients
Onozato R, et al.
Cancer Sci 2007 Aug

Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer
Tahara T, et al.
Cancer Sci 2007 Aug

The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma
Sakano S, et al.
Ann Oncol 2007 Aug

 

Endocrine, Nutritional and Metabolic Diseases

Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children
Bokor S, et al.
Acta Paediatr 2007 Sep;96(9):1350-4

CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals
Bouchard L, et al.
Clin Genet 2007 Sep;72(3):224-9


Cystic fibrosis in a southern Brazilian population: characteristics of 90% of the alleles
Faucz F, et al.
Clin Genet 2007 Sep;72(3):218-23

HLA-DQ Haplotypes in Spanish and German Families with Graves' Disease: Contribution to DQA1*0501-DQB1*0301 Mediated Genetic Susceptibility from Fathers
Ramos-Lopez E, et al.
Thyroid 2007 Aug

Variants in the Cav2.3 ({alpha}1E) Subunit of Voltage-Activated Ca2+ Channels are Associated with Insulin Resistance and Type 2 Diabetes in Pima Indians
Li Muller Y, et al.
Diabetes 2007 Aug

Characterisation of mutations and genotype-phenotype correlation in cystic fibrosis: Experience from India
Shastri SS, et al.
J Cyst Fibros 2007 Aug

Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility  to thyroid dysgenesis
Carre A, et al.
Hum Genet 2007 Aug

Estrogen Receptor Genotypes, Menopausal Status, and the Lipid Effects of Tamoxifen
Ntukidem NI, et al.
Clin Pharmacol Ther 2007 Aug

Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002
Herder C, et al.
Diabetologia 2007 Aug

 

Mental Disorders

Genetic analysis of the TrkB gene and schizophrenia in the Japanese population: Juntendo University Schizophrenia Projects (JUSP)
Higashi M, et al.
Neurosci Lett 2007 Aug

An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
So HC, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Aug

Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes
Steiger H, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Aug

A study of the PEMT gene in schizophrenia
Liu Y, et al.
Neurosci Lett 2007 Aug

VDR gene variants associate with cognitive function and depressive symptoms in old age
Kuningas M, et al.
Neurobiol Aging 2007 Aug

Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia
Wang L, et al.
J Psychopharmacol 2007 Aug

Sex Specific Associations between Common Glucocorticoid Receptor Gene Variants and Hypothalamus-Pituitary-Adrenal Axis Responses to Psychosocial Stress
Kumsta R, et al.
Biol Psychiatry 2007 Aug

Association of the Long Allele of the 5-HTTLPR Polymorphism with Compulsive Craving in Alcohol Dependence
Bleich S, et al.
Alcohol Alcohol 2007 Aug

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia
Muntjewerff JW, et al.
Eur Neuropsychopharmacol 2007 Aug

 

Diseases of the Nervous System and Sense Organs

Haplotypes Spanning the Complement Factor H Gene Are Protective against Age-Related Macular Degeneration
Spencer KL, et al.
Invest Ophthalmol Vis Sci 2007 Sep;48(9):4277-83

Search for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials
Magis D, et al.
Cephalalgia 2007 Aug

Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis
Rubino E, et al.
Cephalalgia 2007 Aug

Glutamate Receptor 6 Gene (GluR6 or GRIK2) Polymorphisms in the Indian Population: A Genetic Association Study on Autism Spectrum Disorder
Dutta S, et al.
Cell Mol Neurobiol 2007 Aug

Apolipoprotein E genotype and lifetime cognitive decline
Kozauer NA, et al.
Int Psychogeriatr 2007 Aug:1-15

MTHFR C677T mutation in central retinal vein occlusion: A case-control study in Chinese population
Gao W, et al.
Thromb Res 2007 Aug

Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints
Mosconi L, et al.
Biol Psychiatry 2007 Aug

The wolframin His611Arg polymorphism influences medication overuse headache
Di Lorenzo C, et al.
Neurosci Lett 2007 Aug

Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease
Tan EK, et al.
Neurobiol Aging 2007 Aug

No association between common variants in glyoxalase 1 and autism spectrum disorders
Rehnstrom K, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Aug

Work-related physical activity and the risk of dementia and Alzheimer's disease
Rovio S, et al.
Int J Geriatr Psychiatry 2007 Aug;22(9):874-82

 

Diseases of the Circulatory System

Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome
Lanfear DE, et al.
Am Heart J 2007 Sep;154(3):561-6

Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients
Fernandez-Cadenas I, et al.
J Thromb Haemost 2007 Sep;5(9):1862-8

Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes
Yang Y, et al.
Exp Physiol 2007 Aug

A Functional Polymorphism of the G{alpha}q (GNAQ) Gene is Associated with Accelerated Mortality in African American Heart Failure
Liggett SB, et al.
Hum Mol Genet 2007 Aug

Association of the Glutathione S-transferase Omega-1 Ala140Asp Polymorphism With  Cerebrovascular Atherosclerosis and Plaque-Associated Interleukin-1{alpha} Expression
Kolsch H, et al.
Stroke 2007 Aug

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease
Taylor JG 6th, et al.
Am J Hematol 2007 Aug

Association of specific haplotypes of GAS6 gene with stroke
Munoz X, et al.
Thromb Haemost 2007 Aug;98(2):406-12

Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women
Pischon T, et al.
Obesity (Silver Spring) 2007 Aug;15(8):2051-60

Plasminogen activator inhibitor-1 4G4G genotype is associated with myocardial infarction but not with stable coronary artery disease
Onalan O, et al.
J Thromb Thrombolysis 2007 Aug

 

Diseases of the Respiratory System

Microsomal Epoxide Hydrolase, Glutathione S-transferase P1, Traffic and Childhood Asthma
Salam MT, et al.
Thorax 2007 Aug

Association between paraoxonase-1 Q192R polymorphism and lung function among Saskatchewan grain handlers
Takayuki S, et al.
Pharmacogenomics 2007 Aug;8(8):901-8

Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism  and concentration, but not allergy sensitization, in a perinatal cohort study
Yang KD, et al.
J Allergy Clin Immunol 2007 Aug

 

Diseases of the Digestive System

T-cell regulatory gene ctla-4 polymorphism/haplotype association with autoimmune  pancreatitis
Chang MC, et al.
Clin Chem 2007 Sep;53(9):1700-5

Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function
Pall H, et al.
J Pediatr 2007 Sep;151(3):255-9

Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease
Xu CF, et al.
World J Gastroenterol 2007 Sep;13(33):4504-8

Interleukin-10 (-819 C/T) and Tumor Necrosis Factor-alpha (-308 G/A) Gene Variants Influence Gastritis and Lymphoid Follicle Development
Achyut BR, et al.
Dig Dis Sci 2007 Aug

Prevalence of OPG and IL-1 gene polymorphisms in chronic periodontitis
Wagner J, et al.
J Clin Periodontol 2007 Aug

Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence?
Schwanke CH, et al.
Braz J Med Biol Res 2007 Aug

Strong Protective Effect of DR3 Against Ulcerative Colitis in the Spanish Population
Gomez-Garcia M, et al.
Am J Gastroenterol 2007 Aug

Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia
Tahara T, et al.
Dig Dis Sci 2007 Aug

 

Complications of Pregnancy, Childbirth, and the Puerperium

Analysis of C-850T and G-308A Polymorphisms of the Tumor Necrosis Factor-alpha Gene in Maya-Mestizo Women with Preeclampsia
Canto-Cetina T, et al.
Hypertens Pregnancy 2007;26(3):283-91

Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) and Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism and Its Association with Preeclampsia in Chinese Women
Li H, et al.
Hypertens Pregnancy 2007;26(3):293-301

 

Diseases of the Skin and Subcutaneous Tissue

Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population
Kim YK, et al.
J Dermatol Sci 2007 Aug

 

Diseases of the Musculoskeletal System and Connective Tissue

MTHFR C677T Polymorphism and Osteoporotic Fractures
Valero C, et al.
Horm Metab Res 2007 Aug;39(8):543-7

Cytokine gene polymorphisms in Colombian patients with systemic lupus erythematosus
Guarnizo-Zuccardi P, et al.
Tissue Antigens 2007 Aug

A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
Linga-Reddy MV, et al.
Tissue Antigens 2007 Aug

Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE
Tangwattanachuleeporn M, et al.
Clin Rheumatol 2007 Aug

Genetic association of IL-21 polymorphisms with systemic lupus erythematosus
Sawalha AH, et al.
Ann Rheum Dis 2007 Aug

Association of angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies
Shehab DK, et al.
J Biomed Sci 2007 Aug

Systemic Lupus Erythematosus in a multiethnic US cohort (LUMINA): Disease expression and outcome in acute-onset lupus
Bertoli AM, et al.
Ann Rheum Dis 2007 Aug

Tumor necrosis factor alpha -308 polymorphism is associated with rheumatoid arthritis in Han population of Eastern China
Chen R, et al.
Rheumatol Int 2007 Aug

 

Certain Conditions Originating in the Perinatal Period

Association of the Growth Hormone Receptor d3-Variant and Catch-up Growth of Preterm Infants with Birth Weight less than 1500 grams
Schreiner F, et al.
J Clin Endocrinol Metab 2007 Aug

 

Symptoms, Signs and Ill-defined Conditions

Specific Polymorphic Variation in the Mitochondrial Genome and Increased In-Hospital Mortality After Severe Trauma
Canter JA, et al.
Ann Surg 2007 Sep;246(3):406-14

 

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Page last reviewed: August 30, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics