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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 16, 2007
Volume 19, No. 7

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

mtDNA evidence: Genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China
Li XY, et al.
Genomics 2007 Aug

[Study of BRCA1 and BRCA2 gene mutations in human sporadic breast cancers]
Zhang HT, et al.
Zhonghua Wai Ke Za Zhi 2007 Apr;45(7):480-2

 

Infectious and Parasitic Diseases

Interleukin-10 Gene (IL10) Polymorphisms and Human Papillomavirus Clearance among Immunosuppressed Adolescents
Shrestha S, et al.
Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1626-32

 

Neoplasms

EGFR exon 20 insertion mutation in Japanese lung cancer
Sasaki H, et al.
Lung Cancer 2007 Aug

Transcription factor-binding sites in the thymidylate synthase gene: predictors of outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin?
Pare L, et al.
Pharmacogenomics J 2007 Aug

Analysis of Genes Critical for Growth Regulation Identifies Insulin-like Growth Factor 2 Receptor Variations with Possible Functional Significance as Risk Factors for Osteosarcoma
Savage SA, et al.
Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1667-74

Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors  in adults
Rajaraman P, et al.
Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1655-61

Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
An J, et al.
Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1633-8

Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in new hampshire
Applebaum KM, et al.
Environ Health Perspect 2007 Aug;115(8):1231-6

ERBB2 genetic polymorphism and breast cancer risk in Chinese women: a population-based case-control study
Qu S, et al.
Breast Cancer Res Treat 2007 Aug

Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin  10 or Fas ligand, increase risk of cervical cancer
Ivansson EL, et al.
Int J Cancer 2007 Aug

TGFB1 Single Nucleotide Polymorphisms are Associated with Adverse Quality of Life in Prostate Cancer Patients Treated with Radiotherapy
Peters CA, et al.
Int J Radiat Oncol Biol Phys 2007 Aug

Genetic Polymorphisms of the Interleukin-18 Gene and Risk of Prostate Cancer
Liu Y, et al.
DNA Cell Biol 2007 Aug;26(8):613-8

Targeting EGFR in bladder cancer
Villares GJ, et al.
World J Urol 2007 Aug

Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer
Van Emburgh BO, et al.
Mol Carcinog 2007 Aug

Association of EcoRI polymorphism of the metastasis-suppressor gene NME1 with susceptibility to and severity of non-small cell lung cancer
Hsieh YS, et al.
Lung Cancer 2007 Aug

Variants in the {alpha}-Methylacyl-CoA Racemase Gene and the Association with Advanced Distal Colorectal Adenoma
Daugherty SE, et al.
Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1536-42

Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer
Levin AM, et al.
Prostate 2007 Aug

Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
Garcia-Closas M, et al.
Int J Cancer 2007 Aug

 

Endocrine, Nutritional and Metabolic Diseases

Investigation of functional gene polymorphisms interleukin-1beta, interleukin-6,  interleukin-10 and tumor necrosis factor in individuals with oral lichen planus
Xavier GM, et al.
J Oral Pathol Med 2007 Sep;36(8):476-81

Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly
Yang WS, et al.
Am J Clin Nutr 2007 Aug;86(2):509-13

Association of NFKB1 -94ins/del ATTG promoter polymorphism with susceptibility to and phenotype of Graves' disease
Kurylowicz A, et al.
Genes Immun 2007 Aug

Analysis of KLF transcription factor family gene variants in type 2 diabetes
Gutierrez-Aguilar R, et al.
BMC Med Genet 2007 Aug;8(1):53

The TCF7L2 locus and type 1 diabetes
Qu HQ & Polychronakos C
BMC Med Genet 2007 Aug;8(1):51

Gene-environment interactions and the diabetes epidemic in India
Mohan V, et al.
Forum Nutr 2007;60:118-26

 

Mental Disorders

The Role of the GABRA2 Polymorphism in Multiplex Alcohol Dependence Families With Minimal Comorbidity: Within-Family Association and Linkage Analyses
Matthews AG, et al.
J Stud Alcohol Drugs 2007 Sep;68(5):625-33

Serotonin transporter gene polymorphism and the phenotypic heterogeneity of adult ADHD
Grevet EH, et al.
J Neural Transm 2007 Aug

Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men
Shin KK, et al.
Cytokine 2007 Aug

Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study
Halsted CH, et al.
Am J Clin Nutr 2007 Aug;86(2):514-21

Association between Single Nucleotide Polymorphisms in the Lysyl Oxidase-Like 1 Gene and Spontaneous Cervical Artery Dissection
Kuhlenbaumer G, et al.
Cerebrovasc Dis 2007 Aug;24(4):343-8

Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults
Mukamal KJ, et al.
Am J Clin Nutr 2007 Aug;86(2):444-50

 

Diseases of the Nervous System and Sense Organs

Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura
Karwautz A, et al.
J Neural Transm 2007 Aug

ITGA4 polymorphisms and susceptibility to multiple sclerosis
O'doherty C, et al.
J Neuroimmunol 2007 Aug

Association of Serotonin 2A Receptor and Lack of Association of CYP1A2 Gene Polymorphism with Tardive Dyskinesia in a Turkish Population
Boke O, et al.
DNA Cell Biol 2007 Aug;26(8):527-31

Replication of linkage on chromosome 7q22 and association of the regional Reelin  gene with working memory in schizophrenia families
Wedenoja J, et al.
Mol Psychiatry 2007 Aug

The mitochondrial pharmacogenomics of haplogroup T: MTND2(*)LHON4917G and antiretroviral therapy-associated peripheral neuropathy
Canter JA, et al.
Pharmacogenomics J 2007 Aug

Common Sequence Variants in the LOXL1 Gene Confer Susceptibility to Exfoliation Glaucoma
Thorleifsson G, et al.
Science 2007 Aug

Modifying Effects of the HFE Polymorphisms on the Association between Lead Burden and Cognitive Decline
Wang FT, et al.
Environ Health Perspect 2007 Aug;115(8):1210-5

Genotype-phenotype correlations for SLC26A4-related deafness
Azaiez H, et al.
Hum Genet 2007 Aug

Impact of the COMT Val(108/158) Met and DAT genotypes on prefrontal function in healthy subjects
Caldu X, et al.
Neuroimage 2007 Jul

 

Diseases of the Circulatory System

Angiotensinogen gene polymorphism as a risk factor for ischemic stroke
Nakase T, et al.
J Clin Neurosci 2007 Aug

The Mediterranean Paradox for Susceptibility Factors in Coronary Heart Disease Extends to Genetics
Lao O, et al.
Ann Hum Genet 2007 Aug

The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients
Vaisi-Raygani A, et al.
Clin Biochem 2007 Jul

The PAI-1 4G/5G Gene Polymorphism and Ischemic Stroke: An Association Study and Meta-Analysis
Attia J, et al.
J Stroke Cerebrovasc Dis 2007 Jul-2007 Aug;16(4):173-9

Association of PAI-1 4G/5G and -844G/A Gene Polymorphism and Changes in PAI-1/tPA Levels in Stroke: A Case-Control Study
Saidi S, et al.
J Stroke Cerebrovasc Dis 2007 Jul-2007 Aug;16(4):153-9

Association of apolipoprotein e gene polymorphism with ischemic stroke involving  large-vessel disease and its relation to serum lipid levels
Saidi S, et al.
J Stroke Cerebrovasc Dis 2007 Jul-2007 Aug;16(4):160-6

 

Diseases of the Respiratory System

HLA Dr-Dq haplotypes and the TNFA-308 polymorphism: associations with asthma and  allergy
Munthe-Kaas MC, et al.
Allergy 2007 Sep;62(9):991-8

Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
Hersh CP, et al.
Respir Res 2007 Aug;8(1):59

Role of IFN-gamma +874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects
Amim LH, et al.
Mol Biol Rep 2007 Aug

IL10 Polymorphisms are Associated with Airflow Obstruction in Severe alpha 1-antitrypsin Deficiency
Demeo DL, et al.
Am J Respir Cell Mol Biol 2007 Aug

 

Diseases of the Genitourinary System

Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis
Davis-Dao CA, et al.
J Clin Endocrinol Metab 2007 Aug

Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis
Hur SE, et al.
J Hum Genet 2007 Aug

 

Diseases of the Musculoskeletal System and Connective Tissue

Assessment of laboratory measurements and -308 TNFalpha gene promoter polymorphisms in normal bone mineral density
Canhao H, et al.
Clin Rheumatol 2007 Aug

The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population
Huang QY & Kung AW
J Hum Genet 2007 Aug

AMPD1 Genotypes and Exercise Capacity in McArdle Patients
Rubio JC, et al.
Int J Sports Med 2007 Aug

 

Injury and Poisoning

Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings
George SZ, et al.
Pain 2007 Aug

 

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Page last reviewed: August 16, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics