Welcome to the  HuGENet™ Case Studies Series

This is an on-line presentation designed to sharpen your epidemiological skills and enhance your knowledge on genomic variation and human diseases.

	Purpose
	Instructions
	Case studies

Purpose

To train health professionals in the practical application of human genome epidemiology (HuGE), which translates gene discoveries to disease prevention by integrating population-based data on gene-disease relationships and interventions.  Students will acquire conceptual and practical tools for critically evaluating the growing scientific literature in specific disease areas.

Instructions

Case studies are presented as follows:

1. Educational objectives
2. Case studies
   • Overview about the topic followed by
   • A summary of the information contained in each article
   • Questions and answers about the article
   • Workspace and an opportunity to submit your answer
   • Our answer key
3. Bibliography
4. Medline Search Opportunity

*Note: Although you may quit and resume at any time, it is important to read the case study in the order in which it is presented.

Case Studies  

Using Whole Genome Scans to Discover Obesity Genes: Implications for the Clinical Utility of Genetic Testing in Obesity  July 2007   Multiple genetic testing for susceptibility to common disease: PPARG and CAPN10 SNP’s and type 2 diabetes  June 2006   Evaluation of the TCF7L2 gene as a predictor of type 2 diabetes  June 2006   Glucocerebrosidase Gene Mutations and Parkinson's Disease  June 2005   Genomics and Cancer Prevention  August 2003   Fictional Scenario To Test Your Knowledge of Gene- Environment Interaction: Rheumatoid Arthritis, Herbal Supplements and Fictitious Rheumatoid Arthritis Gene  August 2002   NOD2 and Crohn disease  December 2001   Factor V Leiden and Venous Thrombosis  December 2001