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naloxone hydrochloride
The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitve manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Narcan | | | | Abbreviation: | | NLX | | |
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