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gemcitabine hydrochloride![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/btn-patient-info.gif) The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | difluorodeoxycytidine gemcitabine | | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | Gemzar | | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | dFdC dFdCyd | | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | LY-188011 | | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20081007171256im_/http://www.cancer.gov/images/spacer.gif) | - 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
- 2'-Deoxy-2',2'-difluorocytidine
- 2'Deoxy-2',2'-Difluorocytidine
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