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ipilimumab
A monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), an antigen that is expressed on activated T-cells and exhibits affinity for B7 co-stimulatory molecules. By binding CTLA4, ipilimumab enhances T-cell activation and blocks B7-1 and B7-2 T-cell co-stimulatory pathways. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody
MOAB CTLA-4
monoclonal antibody CTLA-4 | | | | Abbreviation: | | MDX-CTLA-4 | | | | Code name: | | MDX-010 | | |
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