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17-dimethylaminoethylamino-17-demethoxygeldanamycin
An analogue of the benzoquinone antineoplastic antibiotic geldanamycin. 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Abbreviation: | | 17-DMAG | | |
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