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spiromustine A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) | spirohydantoin mustard | | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) | SHM | | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) | 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl | | ![](https://webarchive.library.unt.edu/eot2008/20081025040717im_/http://www.cancer.gov/images/spacer.gif) |
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