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rubitecan A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | 9-nitrocamptothecin 9-nitro-CPT nitrocamptothecin | | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | Camptogen Orathecin | | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | 9-NC | | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | RFS 2000 | | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) | 9-Nitro-20 (S-)Camptothecin | | ![](https://webarchive.library.unt.edu/eot2008/20081024134902im_/http://www.cancer.gov/images/spacer.gif) |
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