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O6-benzylguanine A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090513052053im_/http://www.cancer.gov/images/spacer.gif) | BG | | ![](https://webarchive.library.unt.edu/eot2008/20090513052053im_/http://www.cancer.gov/images/spacer.gif) |
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