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 Thursday, October 2, 2008 Volume 21   Number 14
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
EGAPP logo

EGAPP Working Group Methods Published
The independent EGAPP Working Group has developed new approaches and optimized existing methods for collecting, analyzing, and grading evidence on analytic and clinical validity and clinical utility of genetic and genomic tests. These methods are described in a paper now available online non-gov warning icon PDF icon (397 KB) in Genetics in Medicine. Learn more about the EGAPP Process non-gov warning icon and CDC’s EGAPP Initiative.

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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Upcoming Events
Genomics Announcements
 

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New article, Genes and Health non-gov warning icon published in the Fall 2008 issue of the CDC Foundation newsletter FrontLine. non-gov warning icon Read about genomics activities and achievements of CDC's National Office of Public Health Genomics.

   
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The Utah Department of Health releases success stories,PDF icon (1.0 MB) about the integration of genomics tools into their state chronic disease programs over the past five years.

   
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Second meeting of the EGAPP Stakeholders Group held in Seattle, Washington.
   
CDC sponsored material

New CDC MMWR article, The Impact of Expanded Newborn Screening – United States 2006, published in the September 19th issue.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Colorectal cancer risk lower with certain gene variationnon-gov warning icon Medical News Today, October 1

Identification of mechanism used by gene to promote metastasis in human cancer cellsnon-gov warning icon Medical News Today, September 30

Poor prognosis for vulvar cancer signalled by extra copies of EGFR genenon-gov warning icon Medical News Today, October 1

What is the relationship between serum folate/vitamin B12 and MTHFR C677T genotypenon-gov warning icon Medical News Today, September 28

Discovery of genetic link between obesity and colon cancer risknon-gov warning icon News-Medical.Net, September 30

Low-cost test for hereditary breast cancer could soon be availablenon-gov warning icon Cancer Research UK, September 26

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Family History

Teens trace family tree to find key to geneticsnon-gov warning icon Baltimore Sun, September 28

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Genetic Testing

Impact of expanded newborn screening in the USnon-gov warning icon phgfoundation, September 29

Genetic testing anywhere: Micro-sizes hand-held 'lab-on-a-chip' devices under developmentnon-gov warning icon Science Daily, September 26

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Other News

Meet to create awareness of genetic disordersnon-gov warning icon The Hindu, October 2

New centre for genetics openingnon-gov warning icon BBC News, September 29

Genetic change may explain reading difficultynon-gov warning icon Reuters Health, October 1

NIH announces funding for new epigenomics
initiative
non-gov warning icon NIH News, September 29

Novel mechanism for regulation of gene expression identifiednon-gov warning icon Science Daily, October 1

Simple twists of fatenon-gov warning icon EurekAlert, September 29

Faster genetic test for flu virus approved in United Statesnon-gov warning icon CBC News, September 30

Successful construction of eukaryotic plasmids containing HBV C genotypenon-gov warning icon Medical News Today, September 28

First genetic research model of retina receptorsnon-gov warning icon News-Medical.Net, September 30

Scientist plans to test for blood pressure genes affected by agenon-gov warning icon Medical News Today, September 27

New gout gene discoverynon-gov warning icon News-Medical.Net, September 30

Saudi project hopes to put Arabs on genetic
map
non-gov warning icon Reuters Health, September 26

Deafness research UK excited about gene therapy breakthroughnon-gov warning icon Medical News Today, September 29

Sexual practice of polygyny skews genetic variabilitynon-gov warning icon Medical News Today, September 26

Genomic laboratory to open in Moscownon-gov warning icon Russia IC, September 29

Gene variant boosts risk of fatty liver diseasenon-gov warning icon News-Medical.Net, September 25

Japan experts identify daytime sleepiness gene, Reuters Health, non-gov warning icon September 29

 
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Genomics in Scientific Literature
Featured Item

Genomics, public health and developing countries: the case of the Mexican National Institute of Genomic Medicine (INMEGEN)
Seguin B, et al.
Nat Rev Genet 2008 Oct;9 Suppl 1:S5-9


 General Articles

The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group
Teutsch SM, et al.
Genet Med 2008 Sep

Correlations between risk gene variants for schizophrenia and brain structure anomalies
Nickl-Jockschat T, et al.
Nervenarzt 2008 Sep

The genetics of cardiovascular disease
Delles C, et al.
Trends Endocrinol Metab 2008 Sep

Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies
Yamaguchi-Kabata Y, et al.
Am J Hum Genet 2008 Sep

Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes
Lin WY & Schaid DJ
Genet Epidemiol 2008 Sep

Update on gene modifiers in cystic fibrosis
Collaco JM & Cutting GR
Curr Opin Pulm Med 2008 Nov;14(6):559-66

PharmGKB: an integrated resource of pharmacogenomic data and knowledge
Gong L, et al.
Curr Protoc Bioinformatics 2008 Sep;Chapter 14:Unit14.7

Molecular genetics of human intracranial aneurysms
Zhang J & Claterbuck RE
Int J Stroke 2008 Nov;3(4):272-87

Modeling gene-by-environment interaction in comorbid depression with alcohol use  disorders via an integrated bioinformatics approach
McEachin RC, et al.
BioData Min 2008;1(1):2

South Africa: from species cradle to genomic applications
Hardy BJ, et al.
Nat Rev Genet 2008 Oct;9 Suppl 1:S19-23

Adaptation to living with a genetic condition or risk: a mini-review
Biesecker B & Erby L
Clin Genet 2008 Sep

Neural networks for genetic epidemiology: past, present, and future
Motsinger-Reif AA & Ritchie MD
BioData Min 2008;1(1):3


 Family History

Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology consortium
Negri E, et al.
Int J Cancer 2008 Sep

Family history and breast cancer tumour characteristics in screened women
Couto E, et al.
Int J Cancer 2008 Sep

Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women
Risendal B, et al.
Cancer Causes Control 2008 Sep

Sibling history of asthma is a risk factor for pain in children with sickle cell  anemia
Field JJ, et al.
Am J Hematol 2008 Aug

Substantial family history of prostate cancer in black men recruited for prostate cancer screening: results from the Prostate Cancer Risk Assessment Program
Mastalski K, et al.
Cancer 2008 Sep

International Registries of Families at High Risk of Pancreatic Cancer
Greenhalf W, et al.
Pancreatology 2008 Sep;8(6):558-65

 

 Genetic Testing

Patient preferences and National Health Service costs: a cost-consequences analysis of cancer genetic services
Griffith GL, et al.
Fam Cancer 2008 Sep

 

 Genome Wide

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
Abraham R, et al.
BMC Med Genomics 2008 Sep;1(1):44

Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
Mick E, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene  associations
Lasky-Su J, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo S, et al.
Nat Genet 2008 Sep

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 1, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: October 2, 2008
Content Source: National Office of Public Health Genomics