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 Thursday, March 20, 2008 Volume 20   Number 12
Update banner Family History Population Research Genomics in Practice General Public
  This weekly update provides information about the impact of human genomic research on disease prevention & population health.
  March is National Colorectal Cancer Awareness Month more info open mailbox for email deliveryGet email updates
Spotlight
image of test tubes Scientific Evidence Insufficient for Utility of Genomic Profiles in measuring genetic risk for common diseases and in developing personalized diet and lifestyle recommendations for disease prevention.
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Sections

 > View Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Upcoming Events

March 2008 Family History and Your Health Newsletter  non-gov warning icon PDF icon (445 KB)

Genetic Literacy: Meeting the Teaching
Challenge
  non-gov warning icon

Utah Genetic Science Learning Center  non-gov warning icon

Genomics Announcements
   
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New issue of the Journal of the American Association (JAMA) on Genetics and Genomics non-gov warning icon published March 19, 2008. Read JAMA News Releases. non-gov warning icon
 
CDC sponsored material
A New Decade of Public Health Genomics at CDC
10th anniversary event of public health genomics at CDC highlights scientific achievements and progress in genomics, genetics, and family history for improving the public’s health.
   
CDC sponsored material

Roadmap for Human Genome Epidemiology
The HuGENet™ Network of Networks workshop on January 24-25, 2008 reviewed progress on the HuGENet™, a knowledge base on genetic variation in human health.

   
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The Genetic Alliance non-gov warning icon is now accepting proposals for Community Centered Family Health History (CCFHH) Program Awards.
   
CDC sponsored material

HuGENet™ What's New
March 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Focus on the genetics of brain tumor formation identifies potential new neuronal tumor
suppressor
non-gov warning icon Medical News Today, March 18

Nuclear protein SATB1 triggers aggressive breast cancernon-gov warning icon News-Medical.Net, March 17

One gene closer to understanding pancreatic
cancer
non-gov warning icon The New York Times, March 18

Innovative study finds alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCCnon-gov warning icon Medical News Today, March 14

Breast cancer risk increased by gene variantnon-gov warning icon
Medical News Today, March 17

DNA detectives find genetic markers for lung cancers most likely to recurnon-gov warning icon News-Medical.Net, March 13

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Cardiovascular Disease

Study links protein to risk of heart diseasenon-gov warning icon Medical News Today, March 18

New educational effort launched on genetic testing for dosing a common blood thinnernon-gov warning icon Medical News Today, March 13

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Ethics, Legal and Social Issues (ELSI)

Genomic tests for use at home considered prematurenon-gov warning icon Medical News Today, March 19

Rony Duncan on genetic testing and young
people
non-gov warning icon The University of Melbourne Voice, March 17

Family communication impacts attitude about genetic counseling/testing for breast cancernon-gov warning icon EurekAert, March 18

Better regulation of home genetic tests needed, researchers urgenon-gov warning icon Science Daily, March 16

Is genetic testing ready for the publicnon-gov warning icon WABC-TV, March 18

Will genetic screening become a way of lifenon-gov warning icon ABC News, March 14

Genomic medicine coming: Health professionals, public unpreparednon-gov warning icon Science Daily, March 18

 

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Family History

Is the risk of breast cancer sometimes geneticnon-gov warning icon islandpacket.com, March 16

Family pedigreenon-gov warning icon Pioneer Local, March 13

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Mental Health

Gene for brain connections linked with autismnon-gov warning icon Reuters Health, March 18

The yin and yang of genes for mood disordersnon-gov warning icon News-Medical.Net, March 13

Past child abuse plus variations in gene result in potent PTSD risk for adultsnon-gov warning icon NIH News, March 18

 

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Obesity

deCODE obesity study sheds light on how genetic factors contribute to major public health
problems
non-gov warning icon News-Medical.Net, March 17

Obesity chokes up the cellular power plant obesity associated with clear changes in gene networks and dysfunction of mitochondrianon-gov warning icon Medical News Today, March 13

Genomics researchers fine-tune marker for common obesity genenon-gov warning icon News-Medical.Net, March 13

 

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Other News

New Tool Reassesses Osteoporosis Risknon-gov warning icon npr.org, March 20

Genotype foods still a decade from the shelves: expertsnon-gov warning icon Food production daily.com, March 17

Europeans can now check out on-line the credentials of laboratories offering genetic testsnon-gov warning icon News-Medical.Net, March 19

Grant could help with Montville boy's disorder,  non-gov warning icon Daily Record, March 17

Bone fractures and bone mineral density linked to gene variantsnon-gov warning icon Medical News Today, March 18

No pain, no protectionnon-gov warning icon Courant.com, March 17

Common gene variants linked to osteoporosisnon-gov warning icon Reuters Health, March 18

Lifetime award in genetics presented to Peter H. Byers by March of Dimesnon-gov warning icon Medical News Today, March 16

Gene targeting raises cure hopesnon-gov warning icon BBC News, March 18

UT-ORNL and UCSD researchers find promise in HIV 'switch'non-gov warning icon EurekAlert, March 16

Inbred Romanian community provides insight into genetic factors associated with vitiligonon-gov warning icon News-Medical.Net, March 18

 
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Genomics in Scientific Literature
Featured Item

Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis
Mao R, et al.
J Hum Genet 2008 Mar

 General Articles

The use of hierarchical models for estimating relative risks of individual genetic variants: An application to a study of melanoma
Capanu M, et al.
Stat Med 2008 Mar

Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience
Christensen KD, et al.
Genet Med 2008 Mar;10(3):207-14

The Hitchhiker's Guide to the Child Neurologist's Genetic Evaluation of Epilepsy
Grill MF, et al.
Semin Pediatr Neurol 2008 Mar;15(1):32-40

Testing informative missingness in genetic studies using case-parent triads
Guo CY, et al.
Eur J Hum Genet 2008 Mar

The HapMap: Charting a Course for Genetic Discovery in Neurological Diseases
Hardy J & Singleton A
Arch Neurol 2008 Mar;65(3):319-21

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
Pe'er I, et al.
Genet Epidemiol 2008 Mar

Large scale DNA sequencing: new challenges emerge-the 2007 Human Genome Variation Society scientific meeting
Oetting WS
Hum Mutat 2008 Mar

Genetic Polymorphisms and Human Aging: Association Studies Deliver
Melzer D
Rejuvenation Res 2008 Mar

Increased genetic counseling support improves communication of genetic information in families
Forrest LE, et al.
Genet Med 2008 Mar;10(3):167-72

 

 Genetic Testing

Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
Bradbury AR, et al.
Genet Med 2008 Mar;10(3):161-6

 

 Family History

Models for predicting BRCA1 and BRCA2 mutations in Han Chinese familial breast and/or ovarian cancer patients
Rao NY, et al.
Breast Cancer Res Treat 2008 Mar

Family history as a predictor of uptake of cancer preventive procedures by women  with a BRCA1 or BRCA2 mutation
Metcalfe KA, et al.
Clin Genet 2008 Mar

Adult Transition From At-Risk Drinking to Alcohol Dependence: The Relationship of Family History and Drinking Motives
Beseler CL, et al.
Alcohol Clin Exp Res 2008 Mar

 

 Genome-Wide Association Studies

Genomewide association for schizophrenia in the CATIE study: results of stage 1
Sullivan PF, et al.
Mol Psychiatry 2008 Mar

Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are  involved in neuroleptic-induced, treatment-resistant tardive dyskinesia
Inada T, et al.
Pharmacogenet Genomics 2008 Apr;18(4):317-23

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 19, 2008, there are HuGE articles in the following areas:

Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: March 20, 2008 (archived document)
Content Source: National Office of Public Health Genomics