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 Thursday, June 19, 2008 Volume 20   Number 25
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
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Skin Cancer Awareness
Skin cancer is the most common form of cancer in the United States. People who have a close relative (parent, sibling, or child) with a specific type of skin cancer called melanoma may be at greater risk of developing the disease than the general population.
Read more.
Sections

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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events

Public Health Grand Rounds: Strengthening the Public Health System to Advance Genomics non-gov warning icon

Looking at My Genes: What Can They Tell Me?

Coalition for Genetic Fairness non-gov warning icon

National Coalition for Health Professional Education in Genetics non-gov warning icon

Genomics Announcements
 

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The Art of Transformational Leadership Award will be presented to Francis Collins, MD, PhD, Director of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health non-gov warning icon on July 12, 2008 at the Genetic Alliance Awards Dinner. non-gov warning icon
   
CDCD sponsored material

What's New in HuGENet™
June 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Leukemia drug's effect improved by gene mutation, non-gov warning icon Medical News Today, June 18

Melanomas "run" in families - CDKN2A gene reveals why, non-gov warning icon News-Medical.Net, June 17

Gene test that can show if cancer drugs will cure you, non-gov warning icon Mail Online, June 17

Discovery of mechanism that prevents cells from transforming into cancer cells, non-gov warning icon News-Medical.Net, June 15

Change lifestyle, change genes, non-gov warning icon CBS News, June 17

 

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Cardiovascular Disease

First gene therapy for heart failure offered at medical center, non-gov warning icon Medical News Today, June 19

Rheumatoid arthritis is a risk factor for cardiovascular disease, non-gov warning icon Medical News Today. June 16

State-of-the-art molecular technology to map genetic patterns in healthy young men with a strong family history of heart attacks, non-gov warning icon Medical News Today, June 18

Heart failure in patients with the genetic disease lqt-2 may be triggered by fever, non-gov warning icon Medical News Today. June 13

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Ethical, Legal, and Social Issues (ELSI)

Lack of diversity in genetic counselors could affect patients, non-gov warning icon NewsWise, June 17

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Family History

Microsoft is funding health-history efforts, non-gov warning icon Deseret News, June 15

Intermountain Genetics Institute at LDS hospital to create electronic tool to gather family history, non-gov warning icon MMD Newswire.com, June 12

Find roots of medical family trees, non-gov warning icon Red Orbit, June 14

 

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Genetic Testing

Benefits of broad genetic testing still limited, non-gov warning icon Medical News Today, June 18

Calif. cracks down on 13 genetic testing startups, non-gov warning icon Yahoo News, June 16

Gene tests drive family to eliminate risks, non-gov warning icon Florida Today, June 16

You've had a genetic test. Now what, non-gov warning icon Technology Review, June 13

Rumailah Hospital begins genetic diseases test, non-gov warning icon Gulf Times, June 16

Genetic data banned for insurers, non-gov warning icon BBC News, June 13

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Mental Health

Known genetic risk for Alzheimer's in whites also places blacks at risk, non-gov warning icon Medical News Today, June 19

Alcohol abuse can damage the brain by decreasing insulin and insulin-like growth factor receptors, non-gov warning icon EurekAlert, June 17

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Other Chronic Diseases

Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases, non-gov warning icon Medical News Today, June 16

Novel DNA microarray chip predicts functional impairment and remission in rheumatoid arthritis, non-gov warning icon EurekAlert, June 13

Specific mutations in the IL2RA gene associated with juvenile idiopathic arthritis, non-gov warning icon Medical News Today, June 16

 

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Other News

Degrees of addiction are genetic, non-gov warning icon Dispatchonline, June 18

European researchers take lid off the genome, non-gov warning icon News-Medical.Net, June 16

DNA knot keeps viral genes tightly corked inside shell, non-gov warning icon June 18

New insights into how genes are governed and why they sometimes go wrong, non-gov warning icon Science Daily, June 16

In the art of a DNA graph, the colors of uniqueness, non-gov warning icon The New York Times, June 17

British Fertility Society issues new guidelines on the use of preimplantation genetic screening, non-gov warning icon UK, Medical News Today, June 13

Conference on personalized medicine hosted by American Association for the Advancement of Science, June 20, non-gov warning icon Medical News Today, June 16

Warfarin dose requirement unaffected by VKORC1L1 gene, non-gov warning icon Medwire News, June 13

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Genomics in Scientific Literature
Featured Item

A searchable database of genetic evidence for psychiatric disorders
Konneker T, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun


 General Articles

Testing for genetic association: A powerful score test
El Galta R, et al.
Stat Med 2008 Jun

Exploiting the proteome to improve the genome-wide genetic analysis of epistasis  in common human diseases
Pattin KA & Moore JH
Hum Genet 2008 Jun

CYP2D6-, CYP2C9- and CYP2C19-based dose adjustments : When do they make sense?
Seeringer A & Kirchheiner J
Internist (Berl) 2008 Jun

Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols
Padmanabhan S, et al.
J Hypertens 2008 Jul;26(7):1275-81

Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Renoprotection  in Diabetic and Nondiabetic Nephropathies
Ruggenenti P, et al.
Clin J Am Soc Nephrol 2008 Jun

Gene-Environment Interaction in Tobacco-Related Cancers
Taioli E
Carcinogenesis 2008 Jun

Genetic Predisposition to Breast Cancer: Past, Present, and Future
Turnbull C & Rahman N
Annu Rev Genomics Hum Genet 2008 Jun

Insight into the genetics of hypertension, a core component of the metabolic syndrome
Pravenec M & Petretto E
Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):393-7

The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an  update
Lyssenko V
Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):385-92

New insights into the genetics of body weight
Dina C
Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):378-84

The fat tail of obesity as told by the genome
Herbert A
Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):366-70

Variable response to opioid treatment: any genetic predictors within sight?
Skorpen F, et al.
Palliat Med 2008 Jun;22(4):310-27

Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii
Carter CJ
Schizophr Bull 2008 Jun

Incorporating the Family as a Critical Context in Genetic Studies of Children: Implications for Understanding Pathways to Risky Behavior and Substance Use
Rende R & Slomkowski C
J Pediatr Psychol 2008 Jun

A searchable database of genetic evidence for psychiatric disorders
Konneker T, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Incidental findings in genetics research using archived DNA
Clayton EW
J Law Med Ethics 2008 Summer;36(2):286-91


 Family History

Family history of prostate cancer and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
Ahn J, et al.
Int J Cancer 2008 Jun

Shared Neurocognitive Dysfunctions in Young Offspring at Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families
Maziade M, et al.
Schizophr Bull 2008 Jun

 

 Genetic Testing

Attitudes to genetic testing in families with multiple cases of bipolar disorder
Meiser B, et al.
Genet Test 2008 Jun;12(2):233-43

 
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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 18, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: June 19, 2008 (archived document)
Content Source: National Office of Public Health Genomics