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Thursday, January 17, 2008 |
Volume
20 Number 3 |
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This weekly update provides information about the impact of human genetic research on disease prevention & public health. |
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New article on “Letting the Genome out of the Bottle — Will We Get Our Wish?” published in the January 10, 2008 issue of the New England Journal of Medicine. Authors: David J. Hunter, MB, BS, ScD, MPH, Muin J. Khoury, MD, PhD, and Jeffrey M. Drazen, MD. Listen to the audio interview. |
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New editorial on "Why should genomic medicine become more evidence-based?" (126KB) published in the December 2007 issue of Genomic Medicine. Authors: Muin J. Khoury, MD, PhD and Linda A. Bradley, PhD. |
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The independent EGAPP Working Group released the first in a planned series of recommendation statements on the use of genetic tests in clinical practice. This first statement addresses the use of cytochrome P450 (CYP450) testing in adults with depression treated with a widely prescribed class of antidepressants.
> Read more about the EGAPP initiative
> Read CDC Press Statement |
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CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research |
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HuGENet™ What's New
January 2008 |
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
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Cardiovascular Disease |
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Scientists associate six new genetic variants with heart disease risk factor, Medical News Today, January 16 |
Gene's effects in blood vessels and high blood pressure in older adults, Medical News Today, January 11 |
International effort finds new genetic variants associated with lipid levels, risk for coronary artery disease, NIH News, January 13 |
Researchers shed light on genetic factors behind UK's biggest killer, News-Medical.Net, January 11 |
Twin studies reveal genetic components leading to cardiac disease, Medical News Today, January 12 |
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Ethical, Legal and Social Issues (ELSI) |
NEJM Editorial warns of downside to 'premature' consumer genomics market, GenomeWeb Daily News, January 16 |
Don't believe the hereditary hype, Chicago Tribune, January 15 |
Genetic testing needed for minorites too,
SouthBendTribune.com, January 16 |
Public can get genes tested, chron.com, January 13 |
Should children be permitted to get genetic testing for BRCA 1 / 2 mutations, Medical News Today, January 16 |
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Mental Disorders |
Diabetes plus Alzheimer's gene ups dementia risk, Reuters Health, January 16 |
New method developed to identify genetic determinants of Alzheimer's disease, EurekAlert, January 14 |
Genes may interact with obstetric complications to boost schizophrenia risk, Medical News Today, January 15 |
Autism risk higher in people with gene variant, NIH News, January 10 |
Mayo Clinic study unveils unprecedented method to predict ALS, Parkinson's disease, EurekAlert, January 15 |
1% of autism due to unstable genes, CBS News, January 10 |
Other News |
Genetics pioneer honored, Baltimore Sun, January 17 |
Study locates cholesterol genes; finds surprises about good, bad cholesterol, Medical News Today, January 14 |
Genomics sizes up,
(last accessed 2/2008) Nature News, January 16 |
Researchers uncover new piece to the puzzle of human height, NIH News, January 13 |
American College of Medical Genetics unveils new website, Yahoo, January 15 |
Chemical first found on Easter Island could treat tuberous sclerosis, News-Medical.Net, January 11 |
Human gene count tumbles again, Science Daily, January 15 |
Gene detection platform made from self-assembled DNA nanostructures, News-Medical.Net, January 11 |
Multiple sclerosis response to treatment may vary depending on patients' genes, Medical News Today, January 15 |
Hundreds of human proteins exploited by HIV revealed by genomic screen, Medical News Today, January 11 |
MIT reports single gene can encode as many as four different functions, News-Medical.Net, January 14 |
Injecting genes into the brain helps in
Parkinson's, Medical News Today, January 11 |
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Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained
Visscher PM, et al.
Eur J Hum Genet 2008 Jan
Genetics of familial amyotrophic lateral sclerosis
Valdmanis PN & Rouleau GA
Neurology 2008 Jan;70(2):144-52
Mechanisms of inherited cancer susceptibility
Hodgson S
J Zhejiang Univ Sci B 2008 Jan;9(1):1-4
Correction of population stratification in large multi-ethnic association studies
Serre D, et al.
PLoS ONE 2008;3(1):e1382
A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia
Cross JT, et al.
Pharmacogenomics J 2008 Jan
Predictors of Contralateral Prophylactic Mastectomy in Women With a BRCA1 or BRCA2 Mutation: The Hereditary Breast Cancer Clinical Study Group
Metcalfe KA, et al.
J Clin Oncol 2008 Jan
A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
Sebastiani P, et al.
BMC Genet 2008 Jan;9(1):6
The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci
Chulada PC, et al.
Hum Genet 2008 Jan
The genetics of nicotine addiction liability: ethical and social policy implications
Hall WD, et al.
Addiction 2008 Jan
Ethical issues raised by incorporation of genetics into the National Birth Defects Prevention Study
Jenkins MM, et al.
Am J Med Genet C Semin Med Genet 2008 Jan
Apolipoprotein E gene polymorphism and myocardial infarction
Kolovou GD, et al.
Int J Cardiol 2008 Jan
Gene polymorphisms in bladder cancer
Franekova M, et al.
Urol Oncol 2008 Jan-2008 Feb;26(1):1-8
Waiting for the genetic revolution
Kamerow D.
BMJ. 2008 Jan 5; 336(7634):22
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers
Metcalfe KA, et al.
Int J Cancer 2008 Jan
A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation
Welton NJ, et al.
Nicotine Tob Res 2008 Jan;10(1):231-40
Genetic background of celiac disease and its clinical implications
Wolters VM & Wijmenga C
Am J Gastroenterol 2008 Jan;103(1):190-5
How family history and risk factors for hypertension relate to ambulatory blood pressure in healthy adults
Goldstein IB, et al.
J Hypertens 2008 Feb;26(2):276-83
Family history of cancer in Brazil: is it being used?
Viana DV, et al.
Fam Cancer 2008 Jan
Variability in Adaptive Behavior in Autism: Evidence for the Importance of Family History
Mazefsky CA, et al.
J Abnorm Child Psychol 2008 Jan
"Are You at Risk for Hereditary Breast Cancer?"
Cohn WF, et al.
J Genet Couns 2008 Jan
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page
For the week ending January 16, 2008, there are HuGE articles in the following areas:
Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning
For more information on HuGE, please visit the HuGENet™ home page
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Provides link to non-governmental sites and does not necessarily represent the views of the Centers for Disease Control and Prevention. |
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