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 Thursday, January 10, 2008 Volume 20   Number 2
Update banner Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Upcoming Events

International Conference on Medical & Community Genetics non-gov warning icon

6th Workshop: Statistical methods for post-genomic data  non-gov warning icon

Genomics and Clinical Microbiology non-gov warning icon



 Let's Go Surfing

Proceedings from Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci   non-gov warning icon

Report of Genomics Workshop: To Establish Clinical Utility of Genetic Tests non-gov warning icon

Hum-Molgen non-gov warning icon


CDC Celebrates 10 Years of Public Health Genomics - January 23, 2008
helix CDC Celebrates 10 Years of Public Health Genomics
On January 23, 2008, CDC’s National Office of Public Health Genomics will host a landmark event, highlighting progress and achievements in the
field of public health genomics during the last 10 years.
dot Learn more
Genomics Announcements
 
CDC sponsored material
New article on “Letting the Genome out of the Bottle — Will We Get Our Wish?”  non-gov warning icon published in the January 10, 2008 issue of the New England Journal of Medicine. Authors: David J. Hunter, MB, BS, ScD, MPH, Muin J. Khoury, MD, PhD, and Jeffrey M. Drazen, MD. Listen to the audio interviewnon-gov warning icon
 
CDC sponsored material
New editorial on "Why should genomic medicine become more evidence-based?"pdf only (126KB) published in the December 2007 issue of Genomic Medicine. Authors: Muin J. Khoury, MD, PhD and Linda A. Bradley, PhD.
   
bullhorn
The independent EGAPP Working Group non-gov warning icon released the first in a planned series of recommendation statements on the use of genetic tests in clinical practice. This first statement addresses the use of cytochrome P450 (CYP450) testing in adults with depression treated with a widely prescribed class of antidepressants.
> Read more about the EGAPP initiative
> Read CDC Press Statement
   
CDC sponsored material
CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research
   
CDC sponsored material
HuGENet™ What's New
January 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

RNA shown to silence cancer suppressor gene, non-gov warning icon Medical News Today, January 10

Fatherhood linked to prostate cancer risknon-gov warning icon Medical News Today, January 8

Breast cancer risk varies among gene carriers,
study
non-gov warning icon Medical News Today, January 9

Researchers discover new biomarker for predicting liver cancer spread and survivalnon-gov warning icon NIH News, January 7

line

Cardiovascular Disease Ethical, Legal and Social Issues (ELSI)

Not only lipids and inflammation: Insight into a new cause of heart attack and other vascular diseasenon-gov warning icon Medical News Today, January 7

Why not to buy a scan of your genomenon-gov warning icon U.S. News & World Report, January 10

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Family History
Family history affects life expectancy, infant mortalitynon-gov warning icon Statesman Journal, January 5

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Genetic Testing

Insurers are considering changes to coverage for genetic testing and related patient counseling servicesnon-gov warning icon AIS Health, January 8

line

Mental Disorders

Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicitynon-gov warning icon Medical News Today, January 9

Recurrent genetic deletion linked to autismnon-gov warning icon EurekAlert, January 7

Rush researchers study genes associated with late onset Alzheimer's diseasenon-gov warning icon Medical News Today, January 7

 

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Other News

People with anorexia less likely to be blamed when biology, genetics explainednon-gov warning icon Medical News Today, January 10

New gene identified for condition that causes blood clots in brainnon-gov warning icon EurekAlert, January 7

'Fort Knox for genes'non-gov warning icon The Huntsville Times, January 9

Recruiting begins for Quebec's genetic mapnon-gov warning icon CBC News, January 7

The mechanics of gene transcriptionnon-gov warning icon Medical News Today, January 9

2 baby girls struggle with rare genetic diseasenon-gov warning icon WCCO.com, January 7

Gene protects newborns from killer respiratory diseasenon-gov warning icon Medical News Today, January 7

Assembling the jigsaw puzzle of drug addictionnon-gov warning icon EurekAlert, January 4

International team identifies 480 genes that control human cell divisionnon-gov warning icon EurekAlert, January 7

Dwarf gene discovery: Explanation for hobbit speciesnon-gov warning icon ABC News, January 3

Michael J. Fox foundation commits up to $3.8 million to develop gene silencing neuroprotective treatment for Parkinson's diseasenon-gov warning icon Medical News Today, January 7

The dopamine transporter gene influences alcohol withdrawal seizuresnon-gov warning icon EurekAlert, January 3

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Genomics in Scientific Literature
Featured Item

Required sample size and nonreplicability thresholds for heterogeneous genetic associations
Moonesinghe R, et al.
Proc Natl Acad Sci U S A 2008 Jan

 General Articles

A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population
Zeng Z, et al.
BMC Infect Dis 2008 Jan;8(1):1

Alzheimer's disease - the ways of prevention
Kivipelto M & Solomon A
J Nutr Health Aging 2008 Jan-2008 Feb;12(1):89S-94S

Sample size requirements for indirect association studies of gene-environment interactions (G x E)
Hein R, et al.
Genet Epidemiol 2007 Dec

The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology
Jacobson EM, et al.
J Autoimmun 2008 Jan

Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer
Decock J, et al.
Clin Genet 2007 Dec

Pathogenic mutations and non-pathogenic DNA polymorphisms in the most common neurodegenerative disorders
Kochanski A
Folia Neuropathol 2007;45(4):164-9

Review article: Inflammatory bowel disease and genetics
Weersma RK, et al.
Aliment Pharmacol Ther 2007 Dec;26 Suppl 2:57-65

 

 Genetic Testing

Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms
Wijnen PA, et al.
Aliment Pharmacol Ther 2007 Dec;26 Suppl 2:211-9

Characterization of Bovine TGM1 and Exclusion as Candidate Gene for Ichthyosis in Chianina
Dardano S, et al.
J Hered 2007 Dec

Pitfalls in the Denaturing High-Performance Liquid Chromatography Analysis of Mitochondrial DNA Mutation
Lim KS, et al.
J Mol Diagn 2007 Dec

A Rapid Polymerase Chain Reaction-Based Screening Method for Identification of All Expanded Alleles of the Fragile X (FMR1) Gene in Newborn and High-Risk Populations
Tassone F, et al.
J Mol Diagn 2007 Dec

 

 Family History

Family History of Cancer Among Children With Brain Tumors: A Critical Review
Dearlove JV, et al.
J Pediatr Hematol Oncol 2008 Jan;30(1):8-14

Predictors of psychological distress among individuals with a strong family history of malignant melanoma
Kasparian NA, et al.
Clin Genet 2007 Dec

How significant is a family history of glaucoma? Experience from the Glaucoma Inheritance Study in Tasmania
Green CM, et al.
Clin Experiment Ophthalmol 2007 Dec;35(9):793-9

Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
Segal P, et al.
J Matern Fetal Neonatal Med 2008 Jan;21(1):73-9

Diagnosis of Fabry Disease via Analysis of Family History
Laney DA & Fernhoff PM
J Genet Couns 2008 Jan

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 9, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: January 10, 2008 (archived document)
Content Source: National Office of Public Health Genomics