New article on “Letting the Genome out of the Bottle — Will We Get Our Wish?”   published in the January 10, 2008 issue of the New England Journal of Medicine. Authors: David J. Hunter, MB, BS, ScD, MPH, Muin J. Khoury, MD, PhD, and Jeffrey M. Drazen, MD. Listen to the audio interview.
	New editorial on "Why should genomic medicine become more evidence-based?" (126KB) published in the December 2007 issue of Genomic Medicine. Authors: Muin J. Khoury, MD, PhD and Linda A. Bradley, PhD.
	The independent EGAPP Working Group  released the first in a planned series of recommendation statements on the use of genetic tests in clinical practice. This first statement addresses the use of cytochrome P450 (CYP450) testing in adults with depression treated with a widely prescribed class of antidepressants. > Read more about the EGAPP initiative > Read CDC Press Statement
	CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research
	HuGENet™ What's New January 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population
Zeng Z, et al.
BMC Infect Dis 2008 Jan;8(1):1

Alzheimer's disease - the ways of prevention
Kivipelto M & Solomon A
J Nutr Health Aging 2008 Jan-2008 Feb;12(1):89S-94S

Sample size requirements for indirect association studies of gene-environment interactions (G x E)
Hein R, et al.
Genet Epidemiol 2007 Dec

The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology
Jacobson EM, et al.
J Autoimmun 2008 Jan

Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer
Decock J, et al.
Clin Genet 2007 Dec

Pathogenic mutations and non-pathogenic DNA polymorphisms in the most common neurodegenerative disorders
Kochanski A
Folia Neuropathol 2007;45(4):164-9

Review article: Inflammatory bowel disease and genetics
Weersma RK, et al.
Aliment Pharmacol Ther 2007 Dec;26 Suppl 2:57-65

 

Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms
Wijnen PA, et al.
Aliment Pharmacol Ther 2007 Dec;26 Suppl 2:211-9

Characterization of Bovine TGM1 and Exclusion as Candidate Gene for Ichthyosis in Chianina
Dardano S, et al.
J Hered 2007 Dec

Pitfalls in the Denaturing High-Performance Liquid Chromatography Analysis of Mitochondrial DNA Mutation
Lim KS, et al.
J Mol Diagn 2007 Dec

A Rapid Polymerase Chain Reaction-Based Screening Method for Identification of All Expanded Alleles of the Fragile X (FMR1) Gene in Newborn and High-Risk Populations
Tassone F, et al.
J Mol Diagn 2007 Dec

 

Family History of Cancer Among Children With Brain Tumors: A Critical Review
Dearlove JV, et al.
J Pediatr Hematol Oncol 2008 Jan;30(1):8-14

Predictors of psychological distress among individuals with a strong family history of malignant melanoma
Kasparian NA, et al.
Clin Genet 2007 Dec

How significant is a family history of glaucoma? Experience from the Glaucoma Inheritance Study in Tasmania
Green CM, et al.
Clin Experiment Ophthalmol 2007 Dec;35(9):793-9

Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
Segal P, et al.
J Matern Fetal Neonatal Med 2008 Jan;21(1):73-9

Diagnosis of Fabry Disease via Analysis of Family History
Laney DA & Fernhoff PM
J Genet Couns 2008 Jan

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 9, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page