Upcoming Public Health Grand Rounds: Strengthening the Public Health System to Advance Genomics, on April 29, 2008, in Ann Arbor, MI. Register for the live webcast,  or register to attend in person.
	HuGE Navigator is now connected with Entrez Gene, a database of NIH’s National Center for Biotechnology Information (NCBI). A link to HuGE Navigator has been added to the menu at the right side of the full report page in Entrez Gene.
	What's New in HuGENet™ April 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Asthma
Gene linked to inherited blood biomarker associated with asthma risk,  NIH News, April 9	Genetic mutation appears to cause asthma,  Medical News Today, April 4

Genetic variations and their influence on risk and treatment of venous thrombosis
Leitner JM, et al.
Pharmacogenomics 2008 Apr;9(4):423-37

Polymorphism in human organic cation transporters and metformin action
Takane H, et al.
Pharmacogenomics 2008 Apr;9(4):415-22

Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies
van der Net JB, et al.
Eur J Hum Genet 2008 Apr

Emerging role of pharmacogenomics in heart failure
McNamara DM
Curr Opin Cardiol 2008 May;23(3):261-8

Genetic determinants of cardiac hypertrophy
Marian AJ
Curr Opin Cardiol 2008 May;23(3):199-205

Atrial fibrillation: evidence for genetically determined disease
Andalib A, et al.
Curr Opin Cardiol 2008 May;23(3):176-83

The future is now - will the real disease gene please stand up?
Martin ER & Schmidt MA
Hum Hered 2008;66(2):127-35

FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests
Rakovski CS, et al.
Hum Hered 2008;66(2):122-6

A family-based likelihood ratio test for general pedigree structures that allows  for genotyping error and missing data
Yang Y, et al.
Hum Hered 2008;66(2):99-110

Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data
Dudbridge F
Hum Hered 2008;66(2):87-98

Review and evaluation of methods correcting for population stratification with a  focus on underlying statistical principles
Tiwari HK, et al.
Hum Hered 2008;66(2):67-86

Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?
Humphries SE, et al.
Curr Opin Lipidol 2008 Apr;19(2):128-32

Defining the spectrum of alleles that contribute to blood lipid concentrations in humans
Kathiresan S, et al.
Curr Opin Lipidol 2008 Apr;19(2):122-7

Single gene contributions: genetic variants of peroxisome proliferator-activated  receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias
Yong EL, et al.
Curr Opin Lipidol 2008 Apr;19(2):106-12

Why study gene-environment interactions?
Ordovas JM & Tai ES
Curr Opin Lipidol 2008 Apr;19(2):158-67

Progress in the genetics of common obesity: size matters
Li S & Loos RJ
Curr Opin Lipidol 2008 Apr;19(2):113-21

Effects of testosterone replacement and its pharmacogenetics on physical performance and metabolism
Zitzmann M
Asian J Androl 2008 May;10(3):364-72

Inference from genome-wide association studies using a novel Markov model
Hosking FJ, et al.
Genet Epidemiol 2008 Mar

The influence of genetics on intracranial aneurysm formation and rupture: current knowledge and its possible impact on future treatment
Krischek B & Tatagiba M
Adv Tech Stand Neurosurg 2008;33:131-47

Genetic contributions to preterm birth: Implications from epidemiological and genetic association studies
Plunkett J & Muglia LJ
Ann Med 2008;40(3):167-79

 

Cascade genetic testing for mismatch repair gene mutations
Mitchell RJ, et al.
Fam Cancer 2008 Apr

Brief Assessment of Parents' Attitudes Toward Testing Minor Children for Hereditary Breast/Ovarian Cancer Genes: Development and Validation of the Pediatric BRCA1/2 Testing Attitudes Scale (P-TAS)
Peshkin BN, et al.
J Pediatr Psychol 2008 Apr

 

Awareness of risk factors amongst first degree relative patients with colorectal  cancer
Akhtar S, et al.
Colorectal Dis 2008 Mar

 

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Hung RJ, et al.
Nature 2008 Apr;452(7187):633-7

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 9, 2008, there are HuGE articles in the following areas:

Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period

For more information on HuGE, please visit the HuGENet™ home page