HuGE Navigator is now connected with Entrez Gene, a database of NIH’s National Center for Biotechnology Information (NCBI). A link to HuGE Navigator has been added to the menu at the right side of the full report page in Entrez Gene. From HuGE Navigator, there is a link back to Entrez Gene. HuGE Navigator supplies Entrez Gene with the PubMed identifiers for citations HuGE Navigator staff curated for human genes.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
Genetic information improves prognosis and relapse-free survival prediction for breast cancer patients,   Medical News Today, April 2	Racial differences in response to bowel cancer genetic risk factor,  Medical News Today, March 31
NIDA researchers identify genetic variant linked to nicotine addiction and lung cancer, NIH News, April 2

FTO: the first gene contributing to common forms of human obesity
Loos RJ & Bouchard C
Obes Rev 2008 Mar

Educational needs in genetic medicine: primary care perspectives
Trinidad SB, et al.
Community Genet 2008;11(3):160-5

Participant characteristics that influence consent for genetic research in a population-based survey: the Baltimore epidemiologic catchment area follow-up
Mezuk B, et al.
Community Genet 2008;11(3):171-8

Cytochrome p450 enzyme polymorphism frequency in indigenous and native american populations: a systematic review
Jaja C, et al.
Community Genet 2008;11(3):141-9

Bioinformatics and genomics for opening new perspective for personalized care
Tanaka H
Stud Health Technol Inform 2008;134:47-58

Role of Pharmacogenetics of Immunosuppressive Drugs in Organ Transplantation
Thervet E, et al.
Ther Drug Monit 2008 Apr;30(2):143-50

The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
Bayley JP, et al.
BMC Med Genet 2008 Mar;9(1):20

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis
Constantine CC, et al.
BMC Med Genet 2008 Mar;9(1):18

Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene
Grant SF, et al.
Expert Rev Mol Diagn 2008 Mar;8(2):199-207

Pharmacogenomics in Alzheimer's disease
Cacabelos R
Methods Mol Biol 2008;448:213-357

Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy
Bosch TM
Methods Mol Biol 2008;448:63-76

Alzheimer's disease: epidemiology, genetics, and beyond
Wang XP & Ding HL
Neurosci Bull 2008 Mar;24(2):105-9

Irinotecan Pharmacogenetics in Japanese Cancer Patients: Roles of UGT1A1(*)6 and  (*)28
Sai K, et al.
Yakugaku Zasshi 2008 Apr;128(4):575-84

 

Telephone Genetic Counseling for High-Risk Women Undergoing BRCA1 and BRCA2 Testing: Rationale and Development of a Randomized Controlled Trial
Peshkin BN, et al.
Genet Test 2008 Spring;12(1):37-52

Professional challenges in cancer genetic testing: who is the patient?
Chan-Smutko G, et al.
Oncologist 2008 Mar;13(3):232-8

Telephone Genetic Counseling for High-Risk Women Undergoing BRCA1 and BRCA2 Testing: Rationale and Development of a Randomized Controlled Trial
Peshkin BN, et al.
Genet Test 2008 Mar

CFTR Mutations in Turkish and North African Cystic Fibrosis Patients in Europe: Implications for Screening
Lakeman P, et al.
Genet Test 2008 Spring;12(1):25-35

Predictive genetic testing of children for adult-onset diseases and psychological harm
Malpas PJ
J Med Ethics 2008 Jul;34(4):275-8

Factors Determining Dissemination of Results and Uptake of Genetic Testing in Families with Known BRCA1/2 Mutations
Finlay E, et al.
Genet Test 2008 Spring;12(1):81-91

Evaluating Online Direct-to-Consumer Marketing of Genetic Tests: Informed Choices or Buyers Beware?
Geransar R & Einsiedel E
Genet Test 2008 Spring;12(1):13-23

The clinical management of BRCA1 and BRCA2 mutation carriers
Gulati AP & Domchek SM
Curr Oncol Rep 2008 Jan;10(1):47-53

Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RET
Moore SW & Zaahl MG
Pediatr Surg Int 2008 Mar

 

Gail Model Risk Factors: Impact of Adding an Extended Family History for Breast Cancer
Crispo A, et al.
Breast J 2008 Mar

Development and preliminary validation of the cancer family impact scale for colorectal cancer
Sinicrope PS, et al.
Genet Test 2008 Spring;12(1):161-9

How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study
Milne BJ, et al.
Psychol Med 2008 Mar:1-10

Familial risks for cancer as the basis for evidence-based clinical referral and counseling
Hemminki K, et al.
Oncologist 2008 Mar;13(3):239-47

 

Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene
Capon F, et al.
Hum Mol Genet 2008 Mar

The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome
Firmann M, et al.
BMC Cardiovasc Disord 2008 Mar;8(1):6

Genome-wide association scan identifies a colorectal cancer susceptibility locus  on 11q23 and replicates risk loci at 8q24 and 18q21
Tenesa A, et al.
Nat Genet 2008 Mar

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci
Liu Y, et al.
PLoS Genet 2008 Mar;4(3):e1000041

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 2, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page