New article, Most Science Studies Appear to Be Tainted By Sloppy Analysis, published in the Wall Street Journal, quoting John Ioannidis, MD, PhD, Muin J. Khoury, MD, PhD, and other experts.
	The U.S. Department of Health and Human Services releases new report, Personalized Health Care: Opportunities, Pathways, Resources, presenting a “long-range plan for achieving much more individualized treatment for patients, especially by using genetic information and health information technology.”  Read the news release
	What's New in HuGENet™ September 2007

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Genetic factors in pain and its treatment
Stamer UM & Stuber F
Curr Opin Anaesthesiol 2007 Oct;20(5):478-84

Probability of detecting disease-associated single nucleotide polymorphisms in case-control genome-wide association studies
Gail MH, et al.
Biostatistics 2007 Sep

Log-linear model based multifactor dimensionality reduction method to detect gene-gene interactions
Lee SY, et al.
Bioinformatics 2007 Sep

Genetics of Alzheimer's disease. A rapidly evolving field
Serretti A, et al.
J Alzheimers Dis 2007 Sep;12(1):73-92

Polymorphisms in the endothelial protein C receptor gene and thrombophilia
Medina P, et al.
Thromb Haemost 2007 Sep;98(3):564-9

Current pharmacogenetic developments in oral anticoagulation therapy: The influence of variant VKORC1 and CYP2C9 alleles
Oldenburg J, et al.
Thromb Haemost 2007 Sep;98(3):570-8

Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications
Niino M, et al.
Expert Rev Neurother 2007 Sep;7(9):1175-88

C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk
Hage FG & Szalai AJ
J Am Coll Cardiol 2007 Sep;50(12):1115-22

Accurate Prediction of Deleterious Protein Kinase Polymorphisms
Torkamani A & Schork NJ
Bioinformatics 2007 Sep

Developing Effective Screening Strategies in Multiple Endocrine Neoplasia Type 1  (MEN 1) on the Basis of Clinical and Sequencing Data of German Patients with MEN  1
Schaaf L, et al.
Exp Clin Endocrinol Diabetes 2007 Sep;115(8):509-17

How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population
Dundar M, et al.
Cancer Genet Cytogenet 2007 Sep;177(2):95-7

Combination of enzyme analysis, allele-specific PCR and sequencing to detect mutations in the GALT gene
Calderon FR, et al.
J Inherit Metab Dis 2007 Sep

 

Executive function and genetic predisposition to schizophrenia-the Maudsley family study
Birkett P, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Sep

Genetic variation in five genes important in telomere biology and risk for breast cancer
Savage SA, et al.
Br J Cancer 2007 Sep;97(6):832-6

The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified
Li WF, et al.
Breast Cancer Res Treat 2007 Sep

Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer
Vairaktaris E, et al.
Acta Oncol 2007 May:1-6

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 19, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period

For more information on HuGE, please visit the HuGENet™ home page