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 Thursday, May 24, 2007     Volume 18   Number 21  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
  This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
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National Stroke Month
Stroke is the third leading cause of death and a major cause of disability
in the United States. Read more.

National Mental Health Month
Mental disorders are real, disabling health conditions that have an immense impact on individuals and families in the United States. Read more.
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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotFamily History
blue dotGenetic Testing
blue dotHuGE Articles
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Genomics Announcements
   
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The NIH Office of Rare Diseases Publishes First Issue of Focus on Rare Diseases Newsletter, May 2007 For free download please click here (95.4KB)


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Featured Item
 


“Check and balance for neuron activity provides insight into schizophrenia, seizures”
non-gov warning icon
(May 23) EurekAlert! reports, “Two genes important for human development and implicated in cancer and schizophrenia also help keep a healthy balance between excitation and inhibition of brain cells, researchers say.”

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“In utero exposure to smoking by mother can increase risk of ADHD” non-gov warning icon
(May 23) EurekAlert! reports, “Women smokers who become pregnant have long been encouraged to reduce or eliminate their nicotine intake.”

“2007 American Society Of Gene Therapy Meeting” non-gov warning icon
(May 22) Medical News Today reports, “The American Society of Gene Therapy (ASGT) is pleased to invite members of the press to a media only event designed to highlight some of the latest and most promising developments in gene therapy products and related technologies.”

“Genes add up risk of autoimmune disease” non-gov warning icon
(May 22) News-Medical.Net reports, “Geneticists have identified a link between the number of copies of a specific gene an individual has and their susceptibility to autoimmune diseases like lupus.”

“Chemotherapy drug shrinks brain tumors” non-gov warning icon
(May 21) EurekAlert! reports, “Cancerous brain tumors appear to respond favorably to the drug temozolomide when used as primary chemotherapy after surgery, and the treatment appears to work best in people missing a certain gene, according to a study published in the May 22, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology.”

“Decoding gene expression in cancer tumors using noninvasive imaging” non-gov warning icon
(May 21) EurekAlert! reports, “By correlating images of cancerous liver tissue with gene expression patterns, a research team led by a radiologist at the University of California, San Diego (UCSD) School of Medicine has developed tools that may some day allow physicians to view a CT image of a cancer tumor and discern its genetic activity.”

“Genes underlie both hyperactivity and poor grades” non-gov warning icon (last accessed 2/2008)
(May 21) Reuters Health reports, “Hyperactive behavior and difficulty in school share the same genetic roots, conclude the authors of a new study of twins.”

“Examining gene expression, drug compounds and liver transplantation” non-gov warning icon
(May 20) Medical News Today reports, “Hepatitis C not only affects more than 3.9 million Americans, but continues to impact and influence the occurrence of related inflammatory conditions.”

“Genetic marker linked to aggressive prostate cancer” non-gov warning icon
(May 20) News-Medical.Net reports, “Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease.”

“New findings on microRNAs” non-gov warning icon
(May 20) News-Medical.Net reports, “Over 30% of our genes are under the control of small molecules called microRNAs.”

“Suicide gene therapy kills bowel cancer cells” non-gov warning icon
(May 20) News-Medical.Net reports, “An innovative type of gene therapy has for the first time succeeded in making bowel cancer cells commit suicide, according to a report in Cancer Research.”

“Targeted nanoparticles incorporating siRNA offer promise for cancer treatment” non-gov warning icon
(May 20) EurekAlert! reports, “The use of targeted nanoparticles offers promising techniques for cancer treatment.”

“Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases” non-gov warning icon
(May 19) Medical News Today reports, “Researchers have identified genetic markers on several chromosomes in the tissue surrounding tumor cells that are associated with breast cancer tumor grade and the presence of lymph node metastases, according to a study in the May 16 issue of JAMA.”

“Genetics and alcohol consumption” non-gov warning icon
(May 19) Medical News Today reports, “Specialists from the Research Institute of Medical Genetics, Russian Academy of Medical Sciences (Tomsk), have found that some variants of the genes responsible for ethanol metabolism impact on blood pressure and lipidic exchange, and raise the risk of coronary atherosclerosis in studies of the Russian population of Western Siberia.”

“A gene to cure blindness” non-gov warning icon
(May 18) Time reports, “It took 15 years to get the right gene, to neutralize a virus that could carry it, and to prove — first in test tubes and then in live animals — that the procedure was safe enough for humans.”

“New web resource for accessing information on genetic diseases” non-gov warning icon
(May 18) Medical News Today reports, “NLM's National Center for Biotechnology Information has collaborated with the Genetic Alliance to launch a new Web site feature designed to help patients, care givers, health professionals, and others easily locate and navigate the vast array of information on genetic disorders that is available from the NLM.”

“Growing nerve cells in 3-d dramatically affects gene expression” non-gov warning icon
(May 17) Science Daily reports, “Nerve cells grown in three-dimensional environments deploy hundreds of different genes compared with cells grown in standard two-dimensional petri dishes, according to a new Brown University study.”

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Genomics in Scientific Literature
Featured Item

Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease. A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational
Arnett DK, et al.
Circulation 2007 May

BRCA2 mutation screening is clinically relevant in breast and early prostate cancer families
Azzouzi AR, et al.
Int J Urol 2007 May;14(5):445-6

Gene-Environment Interactions in the Skeletal Response to Nutrition and Exercise during Growth
Bonjour JP, et al.
Med Sport Sci 2007;51:64-80

Demystifying the ACE polymorphism: from genetics to biology
Castellon R & Hamdi HK
Curr Pharm Des 2007;13(12):1191-8

Genetic polymorphisms in the chemokine and chemokine receptors: impact on clinical course and therapy of the human immunodeficiency virus type 1 infection (HIV-1)
Reiche EM, et al.
Curr Med Chem 2007;14(12):1325-34

Common genetic factors for depression and cardiovascular disease
Bondy B
Dialogues Clin Neurosci 2007;9(1):19-28

Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences
Ferrarezi DA, et al.
Arq Bras Endocrinol Metabol 2007 Mar;51(2):153-9

Genetic aspects of obesity
Dubern B & Clement K
Presse Med 2007 May

Genotype-specific weight loss treatment advice: how close are we?
Adamo KB & Tesson F
Appl Physiol Nutr Metab 2007 Jun;32(3):351-66

Providers' knowledge of genetics: A survey of 5915 individuals and families with genetic conditions
Harvey EK, et al.
Genet Med 2007 May;9(5):259-67

Delivery of cancer genetics services: The Royal Marsden telephone clinic model
Shanley S, et al.
Fam Cancer 2007 May

Selection of family members for communication of cancer risk and barriers to this communication before and after genetic cancer risk assessment
Macdonald DJ, et al.
Genet Med 2007 May;9(5):275-82

Power of genome-wide association studies in the presence of interacting loci
Pickrell J, et al.
Genet Epidemiol 2007 May

Advances in genetic findings on attention deficit hyperactivity disorder
Thapar A, et al.
Psychol Med 2007 May:1-12

Family History
 In The News

No news articles this week.

 

 In The Scientific Literature

Genetic susceptibility to breast cancer
Bradbury AR & Olopade OI
Rev Endocr Metab Disord 2007 May

Family communication regarding inherited high cholesterol: Why and how do patients disclose genetic risk?
van den Nieuwenhoff HW, et al.
Soc Sci Med 2007 May

Breast cancer screening for Korean women must consider traditional risks as well as two genetic risk factors: genetic polymorphisms and inheritable gene mutations
Anderson G, et al.
Cancer Nurs 2007 May-2007 Jun;30(3):213-22

Genetic Testing
 In The News

“Ask Dr. H | Test for malignant-melanoma gene”
(May 21) The Philadelphia Inquirer reports, “My father died last year from malignant melanoma that spread to his brain.”

 

 In The Scientific Literature

Personalized medicine: elusive dream or imminent reality?
Lesko LJ
Clin Pharmacol Ther 2007 Jun;81(6):807-16

Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport
Daly TM, et al.
Clin Chem 2007 May

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 23, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period

For more information on HuGE, please visit the HuGENet™ home page

 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: May 24, 2007 (archived document)
Content Source: National Office of Public Health Genomics