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 Thursday, March 29, 2007     Volume 18   Number 13  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention & public health.
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Mid-West Community Genetics Forum
The Center for Public Health and Community Genomics (CPHCG) at the University of Michigan is launching a new forum to engage and educate Midwest communities on genomics and encourage feedback on issues of genomic research and practice. Read more.

CDC Announcements
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Addressing the Obesity Epidemic: A Genomics Perspective
Newly published article in CDC's Preventing Chronic Disease journal by the Genetics Program This reference links to a non-governmental website of the Oregon Department of Human Services. This article "emphasizes the multifactorial nature of common obesity, which is caused by the interaction of genes, environment, and lifestyle."

The Oregon Genetics Program was established in 2000, and is primarily supported through a cooperative agreement with CDC's National Office of Public Health Genomics.

   
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Deadly Medicine: Creating the Master Race   This reference links to a non-governmental website
The national traveling exhibit “Deadly Medicine, Creating the Master Race,” created by the U.S. Holocaust Memorial Museum, This reference links to a non-governmental website documents 20th century eugenics worldwide, focusing on Nazi Germany. This exhibit will be displayed in CDC's  Global Health Odyssey in the Tom Harkin Global Communications Center from April 30th to August 10th, 2007.

 
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CDC request for applications on Improving Public Health Practice through Translation Research (R18)
The purpose of the RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. Components are included from various CDC offices and centers. Genomics translation research priorities include family history, genetic testing, and genetics for early disease detection and intervention.
   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Fifth National DNA Day to showcase genomic discoveries and careers”  This reference links to a non-governmental website
(Mar 26) NIH News reports, “The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), will mark the fifth annual National DNA Day on April 25 with events aimed at building high school students’ awareness of genetics and genomics.”

“Hemochromatosis gene linked to stroke risk”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 27) Reuters Health reports, “Patients with a specific gene variation for hereditary hemochromatosis, an autosomal recessive disease associated with increased iron accumulation, have more than double the risk of stroke, new research suggests.”

“Japan experts link osteoarthritis to gene variant”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 27) Reuters Health reports, “Researchers in Japan have identified a gene variant that may be responsible for osteoarthritis, a painful condition in the joints that affects more than 200 million people worldwide.”

“Study describes new type of "semi-identical" twins”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 27) Yahoo News reports, “Doctors said on Monday they have identified a third type of twins -- somewhere between identical and fraternal -- after performing extensive genetic tests on two young children.”

“Who gets heart failure? Race takes back seat to diabetes and high blood pressure”  This reference links to a non-governmental website
(Mar 27) EurekAlert! reports, “Diabetes and high blood pressure, two conditions rooted in genetics and environmental surroundings, play a much greater role than race alone in determining who is mostly likely to develop heart failure, according to the latest study from cardiologists at Johns Hopkins. Each year, nearly 300,000 Americans die from heart failure.”

“Biobank large-scale recruiting underway in Manchester”  This reference links to a non-governmental website
(Mar 26) Public Health Genetics Unit reports, “Following a successful pilot study, UK Biobank has begun to roll out its recruitment programme, beginning the greater Manchester area.

“Gene linked to increased risk of stroke”  This reference links to a non-governmental website
(Mar 26) EurekAlert! reports, “One of the most common genetic defects passed on through families significantly increases a person's chance of having a stroke, according to a study published in the March 27, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology.”

“Genetic risk for schizophrenia uncovered by Feinstein researchers”  This reference links to a non-governmental website
(Mar 26) Medical News Today reports, “Psychiatric researchers at The Zucker Hillside Hospital campus of The Feinstein Institute for Medical Research have uncovered evidence of a new gene that appears to increase the risk of developing schizophrenia, a disorder characterized by distorted thinking, hallucinations and a reduced ability to feel normal emotions.”

“Genetics of autism”  This reference links to a non-governmental website
(Mar 26) Medical News Today reports, “Wouter Staal, child - and adolescent psychiatrist at the department of Psychiatry, comments: Autism is an impairment which has a very high hereditary contribution, over 90%. Several linkage and association studies have been performed without consistent replication of data.”

“Mutation to mismatch repair gene associated with colorectal cancer”  This reference links to a non-governmental website
(Mar 26) Medical News Today reports, “Patients with a variant of a DNA repair gene, known as MLH1, may have an increased risk of a subtype of colorectal cancer.”

“Problem gene may cause arthritis – study”  This reference links to a non-governmental website
(Mar 26) iol.ca.za reports, “A tiny quirk in one of the human body's approximately 25 000 genes may be the culprit behind one of the world's most common, and painful, forms of arthritis, according to a study released on Sunday.”

“Sequence variation in the alpha synuclein gene contributes to alcohol craving”  This reference links to a non-governmental website
(Mar 26) EurekAlert! reports, “The protein alpha synuclein (SNCA) plays an important role in the regulation of dopamine function.”

“Using saliva to diagnose primary Sjögren's syndrome”  This reference links to a non-governmental website
(Mar 26) Science Daily reports, “Scientists are reporting that, instead of blood tests and biopsy, saliva can be used to detect primary Sjögren's Syndrome (pSS), an autoimmune disease which affects  approximately 4 million American, 90% being women.”

“Scientists study memory, genetic link”
(Mar 25) WRAL.com reports, “Maura Styczynski sat ramrod straight before a computer screen at Duke University and tried hard to memorize where a series of colored squares flashed.”

“Researchers discover 'vitiligo gene', paving the way for new treatments”  This reference links to a non-governmental website
(Mar 24) Medical News Today reports, “In a study appearing in the March 22 edition of The New England Journal of Medicine, researchers at St George's, University of London, the University of Colorado at Denver and Health Sciences Center (UCDHSC) and the Barbara Davis Center for Childhood Diabetes have discovered a connection between a gene and the chronic skin condition vitiligo, as well as a possible link to an array of other autoimmune diseases.”

“Studies explore lifestyle choices and heart risks”  This reference links to a non-governmental website
(Mar 24) EurekAlert! reports, “Genetics and family history play a large role in a person’s risk for heart disease, but factors in diet, lifestyle and the environment are also thought to influence susceptibility to the disease.”

“Simulated populations used to probe gene mapping”  This reference links to a non-governmental website
(Mar 23) EureKAlert! reports, “More powerful computers are allowing scientists and engineers to conduct simulations that grow more realistic each year.”

“Epigenetic studies will provide a better understanding of disease”  This reference links to a non-governmental website
(Mar 22) Medical News Today reports, “From 26-28 March, the Institute for Research in Biomedicine (IRB Barcelona) will bring together 20 internationally recognised scientists from the USA and Europe working in epigenetics to present their latest work. Invited by Ferran Azor'n, principal investigator at IRB Barcelona, and Tony Kouzarides, director of the Gurdon Institute in the United Kingdom, these scientists will participate in a new Barcelona BioMed Conference, one of a series organised jointly by IRB Barcelona and the BBVA Foundation.”

“House Ways and Means committee passes bill to prohibit genetic discrimination”  This reference links to a non-governmental website
(Mar 22) News Medical.Net reports, “The House Ways and Means Committee on Wednesday by voice vote unanimously approved a bill (HR 493) that would ban discrimination against U.S. residents based on the results of genetic tests, Congress Daily reports.”

“Mutation to mismatch repair gene associated with colorectal cancer”  This reference links to a non-governmental website
(Mar 22) Science Daily reports, “Patients with a variant of a DNA repair gene, known as MLH1, may have an increased risk of a subtype of colorectal cancer, according to a study in the March 21 issue of the Journal of the National Cancer Institute.”

“Ultrathin films deliver DNA as possible gene therapy tool”  This reference links to a non-governmental website
(Mar 22) newswire reports, “Gene therapy - the idea of using genetic instructions rather than drugs to treat disease - has tickled scientists' imaginations for decades, but is not yet a viable therapeutic method.”

“US healthcare provider plans large genetics research programme”  This reference links to a non-governmental website
(Mar 22) The Public Health Genetic Unit reports, “California-based healthcare provider Kaiser Permanente hopes to enrol 500,000 of its 2 million adult members in northern California in an ambitious research programme (the Research Program on Genes, Environment and Health) that aims “to identify genetic and environmental factors that affect human health.”

“Scientists find gene that may regulate colon cancer”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 22) Reuters Health reports, “Scientists have discovered a genetic mutation linked with colon cancer that may work like a spigot, controlling the number of precancerous growths that develop and determining a person's susceptibility to cancer.”

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Genomics in Scientific Literature
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What genome-wide association studies can do for medicine
Christensen K & Murray JC
N Engl J Med 2007 Mar;356(11):1094-7

Cancer genetics: consultants' perceptions of their roles, confidence and satisfaction with knowledge
McCann S, et al.
J Eval Clin Pract 2007 Apr;13(2):276-86

Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond
Gallou-Kabani C, et al.
Clin Chem Lab Med 2007;45(3):321-7

Genotypes, obesity and type 2 diabetes - can genetic information motivate weight loss? A review
Gable D, et al.
Clin Chem Lab Med 2007;45(3):301-8

Nutrigenomics - 2006 update
Kaput J
Clin Chem Lab Med 2007;45(3):279-87

Steroid hormone receptor gene polymorphisms and osteoporosis: a pharmacogenomic review
Gennari L, et al.
Expert Opin Pharmacother 2007 Apr;8(5):537-53

Effect of genetic polymorphisms on the susceptibility to and course of infectious diseases
Kimman TG, et al.
Ned Tijdschr Geneeskd 2007 Mar;151(9):519-24

Cancer genetic counseling in public health care hospitals: the experience of three Brazilian services
Palmero EI, et al.
Community Genet 2007;10(2):110-9

Knowledge of and attitudes about Alzheimer disease genetics: report of a pilot survey and two focus groups
Moscarillo TJ, et al.
Community Genet 2007;10(2):97-102

Why do they do it? A pilot study towards understanding participant motivation and experience in a large genetic epidemiological study of endometriosis
Treloar SA, et al.
Community Genet 2007;10(2):61-71

What genome-wide association studies can do for medicine
Christensen K & Murray JC
N Engl J Med 2007 Mar;356(11):1094-7

Pathogenic mutations in Parkinson disease
Tan EK & Skipper LM
Hum Mutat 2007 Mar

E-Learning Courses in Epilepsy-Concept, Evaluation, and Experience with the E-Learning Course "Genetics of Epilepsies"
Wehrs VH, et al.
Epilepsia 2007 Mar

Incorporating Single-Locus Tests into Haplotype Cladistic Analysis in Case-Control Studies
Liu J, et al.
PLoS Genet 2007 Mar;3(3):e46

Family History
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 In The News

None this week.

 In The Scientific Literature

Family history of hypertension influences left ventricular diastolic function during chronic antihypertensive therapy
Grandi AM, et al.
Am J Hypertens 2007 Apr;20(4):410-5

Genetic Testing
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 In The News

“Gene test shown to measure heart function after transplant”  This reference links to a non-governmental website
(Mar 26) Columbia University Medical Center reports, “New research suggests a genomic test may provide detailed information on how well a transplanted heart is performing.”

“Genetic test for disease: blessing and liability”  This reference links to a non-governmental website
(Mar 26) SABC News reports, “A genetic test could alert a patient that he is prone to colon cancer, so he can take colonoscopies more often to detect and, if necessary, treat the disease in an early phase.”

“Genetic testing”  This reference links to a non-governmental website
(Mar 22) FOX 35 reports, “If a genetic test could tell you whether you'd develop cancer or some other life threatening disease, would you want to know?

 

 In The Scientific Literature

Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription
Fargher EA, et al.
J Clin Pharm Ther 2007 Apr;32(2):187-95

Pediatric otolaryngologists' use of genetic testing
Duncan RD, et al.
Arch Otolaryngol Head Neck Surg 2007 Mar;133(3):231-6

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 29, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Seminar Series of National Human Genome Research Institute, NIH
April 12, 2007 ~ Bethesda, MD

 

1st Course in Genetics of Rheumatic and Auto-inflammatory Diseases   This reference links to a non-governmental website
April 1-4, 2007 ~ Bertinoro di Romagna, Italy

   
  EuroGP 2007- 10th European conference on Genetic Programming  This reference links to a non-governmental website
April 11-13, 2007 ~ Valencia, Spain
   
 

Microbial Genomes 2007  This reference links to a non-governmental website (last accessed 2/2008)
April 11-14, 2007 ~ Hinxton, UK

   

Epigenetics: Regulation of Chromatin Structure in Development and Disease   This reference links to a non-governmental website
April 11-16, 2007 ~ Breckenridge, CO

   
 

American Association for Cancer Research Annual Meeting 2007  This reference links to a non-governmental website (last accessed 2.2008)
April 14-18, 2007 ~ Los Angeles, CA

   
 

 Knowledge integration in public health genomics: evaluation of the epidemiologic evidence
 CDC's Public Health Genomics Monthly Seminar Series  
 April 19, 2007 ~ Rockville, MD (ENVISION - Atlanta, GA)

   
New Listing Development in Gene Expression Profiling  This reference links to a non-governmental website
May 2-3, 2007 ~ London, UK
   
New Listing

Genomics of Common Diseases
July 7-10, 2007 ~ Cambridgeshire, UK


small triangle For a full listing of genetic and genomics-related events, please visit the 2007 Upcoming Events page.
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Let's Go Surfing
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National DNA Day – April 25, 2007
National DNA Day commemorates the completion of the Human Genome Project in April 2003, and the discovery of DNA's double helix, with activities aimed at inspiring the next generation of scientists who will use the human genome sequence to benefit human health. For recent NIH news release about National DNA Day, please see the NIH News web page.         

National DNA Day activities in Utah
The Genomics Program of the Utah Department of Health has planned various educational and wellness activities for the public throughout April.

Kaiser Permanente Research Program on Genes, Environment and Health  This reference links to a non-governmental website
The Research Program on Genes, Environment, and Health is a long-term research program “to identify genetic and environmental factors that affect human health and use that knowledge to improve health care for Kaiser Permanente members and the general public.”

 

 

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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: March 29, 2007 (archived document)
Content Source: National Office of Public Health Genomics