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 Thursday, March 8, 2007     Volume 18   Number 10  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
Spotlight
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March is National Colorectal Cancer Awareness Month
Dad with kids on a hammock

Colorectal cancer is the second leading cause of death from cancer in the United States. Family history can help identify individuals at increased risk of colorectal cancer, which could prompt earlier and more frequent screening and monitoring. Read more

CDC Announcements
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What’s New in HuGENet™
March 2007

 
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ADRB2 Arg16Gly Polymorphism, Lung Function, and Mortality: Results from the Atherosclerosis Risk in Communities Study   This reference links to a non-governmental website
Jill M. Ferdinands, David M. Mannino, Marta L. Gwinn, Molly S. Bray
Newly published study in PloS ONE that examines the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study.

  • PLoS ONE is an "international, peer-reviewed, open-access, online publication from the Public Library of Science (PLoS). PLoS ONE publishes reports on primary research from any scientific discipline. PLoS ONE facilitates the discovery of the connections between papers whether within or between disciplines."
 
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Deadly Medicine: Creating the Master Race  This reference links to a non-governmental website
The national traveling exhibit “Deadly Medicine, Creating the Master Race,” created by the U.S. Holocaust Memorial Museum  This reference links to a non-governmental website, documents 20th century eugenics worldwide, focusing on Nazi Germany. This exhibit will be displayed in CDC's Global Health Odyssey in the Tom Harkin Global Communications Center from April 30th to August 10th, 2007.

   
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CDC request for applications on Improving Public Health Practice through Translation Research (R18) (last accessed 2/2008)
The purpose of the RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. Components are included from various CDC offices and centers. Genomics translation research priorities include family history, genetic testing, and genetics for early disease detection and intervention.
   
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The CDC Grants for Public Health Research Dissertation (R36)
The purpose of this CDC Funding Opportunity Announcement (FOA) is to invite applications for support of public health dissertation research. This program supports research undertaken as part of an academic program to qualify for a doctorate. CDC has developed the Guide to Public Health Research Needs that can be used to identify research priorities and support CDC’s Health Protection Goals.

   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Grant to Yale from Simons Foundation to explore genetic causes of autism”  This reference links to a non-governmental website
(Mar 12) Medical News Today reports, “Researchers at the Yale School of Medicine Child Study Center and 10 other institutions will share a $10 million gift from James and Marilyn Simons of The Simons Foundation to create a databank of DNA samples from autism patients around the country.”

“Toward a test for detecting in childhood the risk of developing bipolar disorder and
schizophrenia”
  This reference links to a non-governmental website
(Mar 14) EurekAlert! reports, “A team from Centre de recherche Université Laval Robert-Giffard (CRULRG) has made significant progress toward finding a way to determine whether a child is likely to one day suffer from bipolar disorder or schizophrenia.”

“Clemson DNA center opens today”  This reference links to a non-governmental website
(Mar 14) The Greenville News reports, “Clemson University will dedicate a new DNA Learning Center today, highlighting a facility that puts the science of DNA into the hands of sixth- through 12th-graders.”

“Genes may determine success of hip replacement surgery”  This reference links to a non-governmental website
(Mar 14) EurekAlert! reports, “The success of long term hip replacement surgery may lie in the genes, suggests research published ahead of print in the Annals of the Rheumatic Diseases.”

“Gene may hold key to treating brain diseases”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 13) Khaleej Times reports, “Scientists in Singapore have identified a brain gene, which may hold the key to treating many disorders and diseases, a published report said on Tuesday.”

“Gene and a region of a chromosome identified that may lead to autism in children”  This reference links to a non-governmental website
(Mar 13) News-Medical.Net reports, “Yale School of Medicine autism experts Fred Volkmar, M.D. and Ami Klin are part of a global research consortium from 19 countries to identify a gene and a region of a chromosome that may lead to autism in children.”

“‘Generalist' genes linked to a variety of learning disorders”  This reference links to a non-governmental website
(Mar 13) Blackwell Publishing reports, “According to a review in the premier issue of Mind, Brain, and Education, the latest research into learning disabilities suggests that ‘generalist’ genes are responsible for a wide range of learning disorders.”

“Ovarian cancer may mimic fallopian tube formation”  This reference links to a non-governmental website
(Mar 13) Science Daily reports, “A new study suggests that ovarian cancer cells form by hijacking a developmental genetic process normally used to form fallopian tubes.”

“Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription”  This reference links to a non-governmental website
(Mar 13) EurekAlert! reports, “The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems.”

“EXT1 gene influences formation of nonhereditary benign bone tumors”  This reference links to a non-governmental website
(Mar 12) Medical News Today reports, “Mutations in a gene known as EXT1 cause Multiple Osteochondromas, a rare hereditary disorder that results in the formation of benign cartilage-covered bone tumors.”

“Gene discovery sheds light on pancreatic cancer”   This reference links to a non-governmental website (last accessed 2/2008)
(Mar 12) Medline Plus reports, “U.S. researchers have identified the gene sequence that causes a rare form of deadly pancreatic cancer.”

“Old vaccines may be better than new”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 12) Nature.com reports, “Genetic changes in a commonly used vaccine for tuberculosis could be contributing to its spotty performance, new research suggests.”

“Gene essential to cerebellum formation discovered by researchers”  This reference links to a non-governmental website
(Mar 10) Medical News Today reports, “Scientists have identified a molecular switch that causes the differentiation of neurons in the cerebellum, a part of the brain that helps to regulate motor functions.”

“Gene research: Indian doctor claims major breakthrough”  This reference links to a non-governmental website
(Mar 10) The Tribune reports, “A US-based Indian doctor, Dr Rajvir Dahiya, and his team of researchers, have discovered a new function of ribonucleic acid (RNA) for gene activation which may open new vistas in the treatment and prevention of various diseases, including cancer.”

“Genetics may play role in heart health”   This reference links to a non-governmental website
(Mar 10) deseretnews.com reports, “More people in the Western world die of heart disease than of any other cause, led by heart attacks and strokes that, in America, together kill roughly 900,000 people a year.”

“Coping with son's genetic disorder”  This reference links to a non-governmental website
(Mar 9) Daily Herald reports, “Some parents dream of their child one day going to college or getting a high paying job -- Tabitha Brown is only looking forward to a time when her 2-year-old will be able to walk or talk.”

”Gene variations contribute to aggression and anger in women”  This reference links to a non-governmental website
(Mar 9) EurekAlert! reports, “Ever wonder why some women seem to be more ill-tempered than others?”

“Individual differences in a clock gene predict decline of performance during sleep
deprivation”
  This reference links to a non-governmental website
(Mar 9) EurekAlert! reports, “People are known to differ markedly in their response to sleep deprivation, but the biological underpinnings of these differences have remained difficult to identify.”

“Computer key unlocks cancer, multiple sclerosis, and Alzheimer's disease”  This reference links to a non-governmental website
(Mar 8) News-Medical.Net reports, “Danish and Belgian researchers have found a computer key that maps genes underlying heritable disorders, such as breast cancer, multiple sclerosis, and Alzheimer's disease.”

“Gene shopping: Parents won't pass on deadly diseases with new procedure”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 8) abc News reports, “There's no doubt that blue-eyed Chloe Kingsbury is a special kid, but how she came into this world can only be described as exceptional.”

“Genetics is often key to treatment”  This reference links to a non-governmental website
(Mar 8) deseretnews.com reports, “Just as some people may be genetically programmed to heart disease, the answer to why people respond differently to the same treatment may be genetic. Understanding a body's genetic secrets may be key to both prevention and selecting treatments.”

“Migraine sufferers may have different genetic makeup”  This reference links to a non-governmental website
(Mar 8) Iowa City Press-Citizen reports, “A new University of Iowa study may provide insight into why some people get migraine headaches.”

“More gene mutations drive cancer than previously thought”  This reference links to a non-governmental website
(Mar 8) Medical News Today reports, “Scientists surveying the human genome have found that many more gene mutations drive the development of cancer than previously thought.”

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Genomics in Scientific Literature
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Attitudes toward genetic testing in patients with inflammatory bowel disease
Lal S, et al.
Eur J Gastroenterol Hepatol 2007 Apr;19(4):321-7

The genetics of bronchial asthma in children
Bierbaum S & Heinzmann A
Respir Med 2007 Mar

Prophylactic salpingo-oophorectomy in a series of 89 women carrying a BRCA1 or a BRCA2 mutation
Laki F, et al.
Cancer 2007 Mar

Searching for Alleles Associated With Complicated Outcomes After Burn Injury
Barber RC, et al.
J Burn Care Res 2007 Mar-2007 Apr;28(2):205-11

MECP2 mutations in males
Villard L
J Med Genet 2007 Mar

Schizophrenia susceptibility genes: in search of a molecular logic and novel drug targets for a devastating disorder
Gogos JA
Int Rev Neurobiol 2007;78:397-422

Spurious Genetic Associations
Sullivan PF
Biol Psychiatry 2007 Mar

Race and ethnicity in genetic research
Sankar P, et al.
Am J Med Genet A 2007 Mar

Time to decide about risk-reducing mastectomy: A case series of BRCA1/2 gene mutation carriers
McCullum M, et al.
BMC Womens Health 2007 Mar;7(1):3

Sudden Infant Death Syndrome: Review of implicated genetic factors
Weese-Mayer DE, et al.
Am J Med Genet A 2007 Mar

Planning for a National Effort to Enable and Accelerate Discoveries in Pharmacogenetics: The NIH Pharmacogenetics Research Network
Long RM
Clin Pharmacol Ther 2007 Mar;81(3):450-4

Should Pharmacogenomic Studies be Required for New Drug Approval?
Relling MV & Hoffman JM
Clin Pharmacol Ther 2007 Mar;81(3):425-8

iCartiGD: the Integrated Cartilage Gene Database
Yeung MY, et al.
BMC Genet 2007;8:4

Family History
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 In The News

“Framingham study shows parents who live long pass on lower risk of cardiovascular disease”  This reference links to a non-governmental website
(Mar 13) NIH News reports, “New evidence suggests that if you could choose your parents, you could reduce your risk of cardiovascular disease.”

“Genetics may play role in heart health”  This reference links to a non-governmental website
(Mar 10) deseretnews.com reports, “More people in the Western world die of heart disease than of any other cause, led by heart attacks and strokes that, in America, together kill roughly 900,000 people a year.”

 

 In The Scientific Literature

Prevalence and Characteristics of a Family History of End-Stage Renal Disease among Adults in the United States Population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) Renal Cohort Study
McClellan W, et al.
J Am Soc Nephrol 2007 Mar

Cancer genetics clinics and the surgeon: a valuable role for family history screening
Williams GL, et al.
Ann R Coll Surg Engl 2007 Mar;89(2):127-9

Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups
Philips B, et al.
Am J Cardiol 2007 Mar;99(6):825-9

 

Genetic Testing
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 In The News

“House subcommittee considers bill that would prohibit genetic discrimination” This reference links to a non-governmental website
(Mar 12) Medical News Today reports, “The House Energy and Commerce Subcommittee on Health on Thursday held a hearing on legislation (HR 493) to ban discrimination against U.S. residents based on the results of genetic tests, CQ HealthBeat reports.”

 

 In The Scientific Literature

Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: a systematic review
Gerhardus A, et al.
Eur J Hum Genet 2007 Mar

Attitudes toward genetic testing in patients with inflammatory bowel disease
Lal S, et al.
Eur J Gastroenterol Hepatol 2007 Apr;19(4):321-7

Diagnosis of families with familial hypercholesterolaemia and/or Apo B-100 defect by means of DNA analysis of LDL-receptor gene mutations
Widhalm K, et al.
J Inherit Metab Dis 2007 Mar

Selective screening for inborn errors of metabolism on clinical patients using tandem mass spectrometry in China: A four-year report
Han LS, et al.
J Inherit Metab Dis 2007 Mar

Early Initiation of Colorectal Cancer Screening in Individuals with Affected First-degree Relatives
Murff HJ, et al.
J Gen Intern Med 2007 Jan;22(1):121-6

Predictive testing for Huntington's disease
Tibben A
Brain Res Bull 2007 Apr;72(2-3):165-71

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 14, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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microRNA in Human Disease and Development  This reference links to a non-governmental website
March 29-30, 2007 ~ Boston, MA

   
 

17th European Congress of Clinical Microbiology and Infectious Diseases  This reference links to a non-governmental website
March 31-April 3, 2007 ~ Munich, Germany

   
 

1st Course in Genetics of Rheumatic and Auto-inflammatory Diseases   This reference links to a non-governmental website
April 1-4, 2007 ~ Bertinoro di Romagna, Italy

   
New Listing EuroGP 2007- 10th European conference on Genetic Programming  This reference links to a non-governmental website
April 11-13, 2007 ~ Valencia, Spain
   
 

Microbial Genomes 2007  This reference links to a non-governmental website (last accessed 2/2008)
April 11-14, 2007 ~ Hinxton, UK

   
 

Epigenetics: Regulation of Chromatin Structure in Development and Disease  This reference links to a non-governmental website
April 11-16, 2007 ~ Breckenridge, CO


For a full listing of events, please visit the Upcoming Events page.
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Let's Go Surfing
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New media campaign for colorectal cancer in Utah
The Utah Cancer Action Network and the Cancer Control Program  This reference links to a non-governmental website in the Utah Department of Health has launched a new media campaign called "No excuses" to promote colorectal cancer screening in people 50 years and older.

The Centre for Applied Genomics This reference links to a non-governmental website
The Centre for Applied Genomics (TCAG) provides genomics infrastructure to facilitate a wide variety of research, including human genomics and disease, model organisms, and agricultural and food sciences.

National DNA Day – April 25, 2007
National DNA Day commemorates the completion of the Human Genome Project in April 2003, and the discovery of DNA's double helix, with activities aimed at inspiring the next generation of scientists who will use the human genome sequence to benefit human health.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: March 15, 2007 (archived document)
Content Source: National Office of Public Health Genomics