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| Thursday, June 7, 2007 |
Volume
18 Number 23 |
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This weekly update provides information about the impact of human genetic research on disease prevention & public health. |
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Skin cancer is the most common form of cancer in the United States. Most skin cancers are caused by exposure to ultraviolet rays from the sun. People who have a close relative (parent, sibling, or child) with a specific type of skin cancer called melanoma may be at greater risk of developing the disease than the general population.
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- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
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“6 Billion bits of data about me, me, me!” 
(June 3) New York Times reports, “James D. Watson, who helped crack the DNA code half a century ago, last week became the first person handed the full text of his own DNA on a small computer disk.” |
“Scientists 'home In' on new breast cancer genes in groundbreaking study, UK”
(June 7) Medical News Today reports, “Cancer Research UK scientists have isolated five regions of the genome containing genes which can increase a woman's risk of developing breast cancer, reveals a major international study published online in Nature .”
“Research team identifies new Alzheimer's gene”
(June 6) EurekAlert! reports, “A study comparing more genetic markers in the DNA of people with and without Alzheimer’s disease than ever before has enabled researchers to identify a common gene that appears to increase a person’s risk for developing Alzheimer’s disease.”
“Genetic mutations identified for type of gastric cancer”
(June 4) Medical News Today reports, “Researchers have identified novel genetic mutations that are linked to hereditary diffuse gastric cancer, with these mutations being due to both independent mutational events and common ancestry, according to a study in the June 6 issue of JAMA.”
“Genetic testing helps cancer survivors fight for their loved ones”
(June 3) News-Medical.Net reports, “Family members of those who are successfully fighting cancer are protecting themselves and their families from the disease through genetic testing and hereditary cancer risk assessment.”
“Gene tests may boost lung cancer care”
(last accessed 2/2008)
(June 2) Medline Plus reports, “U.S. researchers say they've developed new tests that can determine the precise genetic pathways that lead to lung cancer.”
“Researchers discover inherited mutation for leukemia”
(June 1) EurekAlert! reports, “Researchers have discovered the first inherited gene mutation that increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease.”
“Students explore careers in cancer genetics”
(May 31) Newswise reports, “Cancer casts a shadow of fear over many families.”
“Novel delivery method of insulin gene to combat juvenile diabetes developed”
(June 4) Medical News Today reports, “A safer method to deliver the insulin gene to diabetes patients using nanoparticles, was presented today at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.”
“Genetic testing for suicidal tendencies”
(June 5) Technology Review reports, “New analyses of a large, nationwide study of antidepressant treatment have identified genetic variations linked to a controversial and concerning side effect: suicidal thinking.”
“Large genome study finds genes behind common diseases”
(June 7) Medical News Today reports, “In the largest ever study published to date, a consortium of UK scientists has discovered over 20 genes and regions of the human genome that contribute to diseases such as diabetes, rheumatoid arthritis and coronary heart disease.”
“Gene findings: Disease-by-disease”
(June 6) BBC News reports, “A team of UK researchers have identified several genes and regions of the genome involved in seven common diseases - but what are the implications for people suffering from the conditions?”
“Genome miners rush to stake claims”
(last accessed 2/2008)
(June 6) Nature.com reports, “This February, Laura Scott, a genetic epidemiologist at the University of Michigan, Ann Arbor, spent her holiday sitting in a ski lodge in front of her computer, "very occasionally trying to go out and ski".”
“Surgeons gain full control over gene transfer technology”
(June 4) Medical News Today reports, “A viral vector delivery system that permits real-time, direct MRI monitoring of vector distribution within the brain was presented today at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.”
“MUHC-led international team identifies gene responsible for blindness in infants and children”
(June 3) EurekAlert! reports, “A MUHC-led study identifies a gene responsible for Leber Congenital Amaurosis (LCA), the most common cause of congenital blindness in infants and small children.”
“Endocrine researchers to discuss gene that may be linked to Polycystic Ovary Syndrome”
(June 2) Science Daily reports, “Researchers in endocrinology and obstetrics and gynecology at Cedars-Sinai Medical Center will discuss a gene that appears to play a role in the development of polycystic ovary syndrome (PCOS), the most common endocrine disorder among reproductive-age women, at upcoming meetings.”
“Co-discoverer of DNA presented with his own genome sequence”
(June 1) Medical News Today reports, “James Watson, Nobel Laureate and co-discoverer with Francis Crick of the DNA double helix was presented this week with his own genome sequence.”
“Genes of the rich and famous”
(May 31) Forbes.com reports, “What human genetics needs is a celebrity spokesman.”
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PREDICT-1 (CNA106030): the first powered, prospective trial of pharmacogenetic screening to reduce drug adverse events
Hughes S, et al.
Pharm Stat 2007 May
Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease
Rodriguez S, et al.
Hum Genet 2007 May
Genetic Association of Complex Traits: Using Idiopathic Scoliosis as an Example
Cheng JC, et al.
Clin Orthop Relat Res 2007 May
Detecting haplotype effects in genomewide association studies
Huang BE, et al.
Genet Epidemiol 2007 Jun
The Impact of Breast Cancer Genetic Risk Assessment on Intentions to Perform Cancer Surveillance Behaviors
Bennett P, et al.
J Genet Couns 2007 Jun
Genetic testing for heart disease susceptibility: potential impact on motivation to quit smoking
Sanderson S & Michie S
Clin Genet 2007 Jun;71(6):501-10
A Unified Approach for Quantifying, Testing and Correcting Population Stratification in Case-Control Association Studies
Gorroochurn P, et al.
Hum Hered 2007 May;64(3):149-59
Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes
Wessel J, et al.
Genet Epidemiol 2007 Jun
The clinical role of genetic polymorphisms in drug-metabolizing enzymes
Tomalik-Scharte D, et al.
Pharmacogenomics J 2007 Jun
Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research
Arranz MJ & de Leon J
Mol Psychiatry 2007 Jun
Pharmacogenetics of beta-Blockers
Shin J & Johnson JA
Pharmacotherapy 2007 Jun;27(6):874-87
Quantitative trait association in parent offspring trios: Extension of case/pseudocontrol method and comparison of prospective and retrospective approaches
Wheeler E & Cordell HJ
Genet Epidemiol 2007 Jun
Optimal designs for two-stage genome-wide association studies
Skol AD, et al.
Genet Epidemiol 2007 Jun
Pharmacogenetics and asthma: false hope or new dawn?
Hall IP & Sayers I
Eur Respir J 2007 Jun;29(6):1239-45
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page
For the week ending June 6, 2007, there are HuGE articles in the following areas:
Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning
For more information on HuGE, please visit the HuGENet™ home page |
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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
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Provides link to non-governmental sites and does not necessarily represent the views of the Centers for Disease Control and Prevention. |
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