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 Thursday, Feb. 15, 2007     Volume 18   Number 7  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
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February is American Heart Month
Heart disease is the leading cause of death in the United States and a major cause of disability.  Family medical history offers important information for identifying risk in individuals.

Click here for more information.

CDC Announcements
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Public Health Genomics: "Closing the Gap Between Human Genome Discoveries and Population Health"
The CDC National Office of Public Health Genomics presents a monthly seminar series exploring various topics on the intersection of genomics, medicine, and public health.  

Suggested readings:
   
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HuGE What's New
February 2007
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Variation in gene caspase-8 may help protect against breast cancer”  This reference links to a non-governmental website
(Feb 13) News-Medical.Net reports, “A large-scale analysis of data on breast cancer risk has concluded that a common variation in the gene caspase-8 (CASP8) is associated with a somewhat lower risk of the disease. Variants are small changes that occur in a gene sequence.”

“Kaiser launches genetics study”  This reference links to a non-governmental website
(Feb 14) SiliconValley.com reports, “Health-care provider Kaiser Permanente has launched a massive study into the complex interplay of genetics, environment and lifestyles that cause many common diseases.”

“Patenting Life”  This reference links to a non-governmental website
(Feb 13) The New York Times reports, “YOU, or someone you love, may die because of a gene patent that should never have been granted in the first place. Sound far-fetched?”

“Study identifies gene variation for mild form of Schizophrenia” This reference links to a non-governmental website
(Feb 13) SAWF News reports, “University of Iowa researchers have learned more about a genetic variation that is a small risk factor for a mild form of schizophrenia, yet also is associated with improved overall survival.”

“A unique twin study on the increased cardiometabolic risk in obesity” This reference links to a non-governmental website
(Feb 13) EurekAlert! reports, “Study finds that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.”

“Biochip allows genes to express themselves” This reference links to a non-governmental website
(Feb 13) News-Medical.Net reports, “Biochip platforms that work as artificial cells are attractive for medical diagnostics, interrogation of biological processes, and for the production of important biomolecules.”

“New patented technology for next generation of DNA and RNA microarrays” This reference links to a non-governmental website
(Feb 13) News-Medical.Net reports, “A novel invention developed by a scientist from New York Institute of Technology (NYIT) could revolutionize biological and clinical research and may lead to treatments for cancer, AIDS, Alzheimer's, diabetes, and genetic and infectious diseases.”

“People with genetic conditions twice as likely to report health insurance denial” This reference links to a non-governmental website
(Feb 12) eMaxHealth reports, “A new study published in the February 2007 issue of the American Journal of Medical Genetics reveals that individuals with genetic conditions are twice as likely to report having been denied health insurance than individuals with other chronic illnesses.”

“Hooked By Genes: Studies Identify DNA Regions Linked To Nicotine Dependence” This reference links to a non-governmental website
(Feb 12) Science Daily reports, “Americans are bombarded with antismoking messages, yet at least 65 million of us continue to light up.”

“Baby's Breath: Newborns With Respiratory Distress Potentially Have Rare Genetic
Disease”
 This reference links to a non-governmental website
(Feb 12) Science Daily reports, “Newborns with respiratory distress should be evaluated for primary ciliary dyskinesia, a rare genetic disease that has features similar to cystic fibrosis, says Thomas Ferkol, M.D., from Washington University School of Medicine in St. Louis.”

“New diagnostic technology for routine prenatal genetic testing” This reference links to a non-governmental website
(Feb 11) News-Medical.Net reports, “Research studies demonstrating the viability of an approach to routinely detect the presence of fetal DNA in a mother's blood to accurately diagnose or rule out genetic defects -- as early as the first trimester -- was presented today at the 27th Annual Meeting of the Society for Maternal-Fetal Medicine being held in San Francisco.”

“Which genome variants matter?” This reference links to a non-governmental website
(Feb 9) EurekAlert! reports, “Findings published today in Science will accelerate the search for genes involved in human disease.”

“Cold Spring Harbor Laboratory Scientists Discover New Gene That Prevents Multiple Types Of Cancer” This reference links to a non-governmental website
(Feb 9) Medical News Today reports, “A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL).”

“International Study Points To New Breast Cancer-susceptibility Gene” This reference links to a non-governmental website
(Feb 9) Science Daily reports, “A gene whose existence was detected only a couple of years ago may increase women's risk of breast cancer when inherited in a mutated form, and may contribute to prostate cancer as well, researchers at Dana-Farber Cancer Institute and colleagues in Finland report in a new study.”

“Common Gene Version Optimizes Thinking — but With a Possible Downside” This reference links to a non-governmental website
(Feb 8) NIH News reports, “Most people inherit a version of a gene that optimizes their brain’s thinking circuitry, yet also appears to increase risk for schizophrenia*, a severe mental illness marked by impaired thinking, scientists at the National Institutes of Health’s (NIH) National Institute of Mental Health (NIMH) have discovered.”

“Second gene discovered for recessive form of brittle bone disease” This reference links to a non-governmental website
(Feb 8) EurekAlert! reports, “Researchers at the National Institutes of Health and other institutions have found a second genetic defect that accounts for previously unexplained forms of osteogenesis imperfecta (OI), a disorder that weakens bones, sometimes results in frequent fractures and is sometimes fatal.”

“Genes may trigger repeated premature birth in blacks”
(Feb 8) STLtoday.com reports, “Black women may be genetically predisposed to giving birth prematurely, according to a new study from Washington University.”

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Genomics in Scientific Literature
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Association of genetic variations with nonfatal venous thrombosis in postmenopausal women
Smith NL, et al.
JAMA 2007 Feb;297(5):489-98

An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification
Nicodemus KK, et al.
Am J Hum Genet 2007 Jan;80(1):178-85

Access to health insurance: Experiences and attitudes of those with genetic versus non-genetic medical conditions
Kass NE, et al.
Am J Med Genet A 2007 Feb

Genetics of intracranial aneurysms
Nahed BV, et al.
Neurosurgery 2007 Feb;60(2):213-25; discussion 225-6

The genomic era and serious mental illness: a potential application for psychiatric genetic counseling Austin JC & Honer WG
Psychiatr Serv 2007 Feb;58(2):254-61

Pharmacogenetics of antiparkinsonian drug treatment: a systematic review
Arbouw ME, et al.
Pharmacogenomics 2007 Feb;8(2):159-76

Statistical methods for haplotype-based matched case-control association studies
Zhang H, et al.
Genet Epidemiol 2007 Feb

Various pharmacogenetic aspects of antiepileptic drug therapy : a review
Mann MW & Pons G
CNS Drugs 2007;21(2):143-64

Selected genetic disorders affecting Ashkenazi Jewish families
Weinstein LB
Fam Community Health 2007 Jan-2007 Mar;30(1):50-62

Family History
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“'Gene wrapper' discovery aids cancer fight” This reference links to a non-governmental website
(Feb 15) ABC News Online reports, “Cancer researchers in Sydney hope to prevent many early-onset cancer diagnoses with a new discovery.”

“Survey finds perceived risk of recurrence low in African-American breast cancer survivors” This reference links to a non-governmental website
(Feb 15) EurekAlert! reports, “A unique survey of African American breast cancer survivors at heightened risk for hereditary breast cancer has found the majority do not believe they have an increased chance of developing the cancer again.”

“Mechanism driving iron overload in thalassemia identified” This reference links to a non-governmental website
(Feb 14) News-Medical.Net reports, “Led by researchers at Weill Cornell Medical College in New York City, an international group of scientists has pinpointed a specific genetic relationship as the cause of dangerous iron overload in persons with a form of the inherited blood disease, beta-thalassemia.”

Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol DeFaria Yeh D, et al.
Am J Cardiol 2007 Jan;99(1):1-4

Genetic Testing
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“Brigham team devises model to better gauge heart risk” This reference links to a non-governmental website
(Feb 14) Boston.com reports, “It is a fact that has long frustrated doctors and their patients: Up to 20 percent of women who suffer heart attacks and other coronary problems had no obvious risk factors -- no high blood pressure or elevated cholesterol.”

“Tumors' Genetic Profile Captured By Technology” This reference links to a non-governmental website
(Feb 14) Medical News Today reports, “A study led by researchers at Dana-Farber Cancer Institute and Broad Institute of the Massachusetts Institute of Technology and Harvard University provides the first demonstration of a practical method of screening tumors for cancer-related gene abnormalities that might be treated with "targeted" drugs.”

“U-M team: Genetic testing sheds light on degenerative eye disease” This reference links to a non-governmental website
(Feb 13) EurekAlert! reports, “Genetic testing for eye disease is providing vital information about complex retinal diseases, especially when used to confirm a clinician’s diagnosis.”

“Simple 2-gene test sorts out similar gastrointestinal cancers” This reference links to a non-governmental website
(Feb 12) EurekAlert! reports, “A powerful two-gene test distinguishes between a pair of nearly identical gastrointestinal cancers that require radically different courses of treatment, researchers report this week in the online Early Edition of the Proceedings of the National Academy of Sciences.”

“Type-2 diabetes genes identified” This reference links to a non-governmental website
(Feb 11) News-Medical.Net reports, “The most important genes associated with a risk of developing type-2 diabetes have been identified, scientists report today in a new study.”

High-throughput oncogene mutation profiling in human cancer
Thomas RK, et al.
Nat Genet 2007 Feb

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 14, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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New This Week

Managing Incidental Findings in Human Subjects Research: From Imaging to Genomics This reference links to a non-governmental website
May 1, 2007 ~ Minneapolis, MN

What is the role of behavioral and social sciences in translating genetic research into population health benefits?
March 12, 2007 ~ Rockville, MD (ENVISION- Atlanta, GA)

   
New This Week

7th course in Bioinformatics for Molecular Biologists This reference links to a non-governmental website
March 18-22, 2007 ~ Bertinoro di Romagna, Italy

   
New This Week

microRNA This reference links to a non-governmental website
March 29-30, 2007 ~ Boston, Ma

   
New This Week

1st Course in Genetics of Rheumatic and Autoinflammatory Disease This reference links to a non-governmental website
April 1-4, 2007 ~ Bertinoro di Romagna, Italy

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Let's Go Surfing
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Public Health Genetics Unit, UK, Newsletter, February 2007  This reference links to a non-governmental website
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health implications.

Minnesota Gene Pool Weblog  This reference links to a non-governmental website
On-line weblog for public health practitioners and healthcare professionals who are interested in the role of genetics and genomics in health promotion and disease prevention.

From Gene to Function  This reference links to a non-governmental website
The Graphics Gallery of the National Health Museum Resource Center is a series of labeled diagrams with explanations representing the important processes of biotechnology. Each diagram is followed by a summary of information, providing a context for the process illustrated.

DNA Rainbow  This reference links to a non-governmental website
Two scientists have rendered amazing pictures using datafiles from the human genome project. They assigned different colors to the DNA and rendered images showing interesting patterns and strange structures of our chromosomes.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: February 15, 2007 (archived document)
Content Source: National Office of Public Health Genomics