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 Thursday, April 12, 2007     Volume 18   Number 15  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on
disease prevention & public health.
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April is National Autism Awareness Month
Autism is one of a group of developmental disorders known as autism spectrum disorders (ASDs). Scientists think that both genes and the environment play a role in ASDs. Family studies have been helpful in understanding how genes contribute to autism. Read more.

CDC Announcements
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HHS Secretary Michael Leavitt Unveils His Personalized Health Care Initiative at a Personalized Medicine Coalition Luncheon   This reference links to a non-governmental website
Michael O. Leavitt, Secretary of Health and Human Services, “has identified Personalized Health Care as one of his top priorities, and has outlined new steps that HHS is taking to achieving gene-based medical care combined with health information technology.”

   
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New CDC.gov Home Page Coming Soon
This month CDC will launch a new home page and second-level pages, providing easier access to public health information on the CDC.gov website.

   
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April seminar presented by CDC’s National Office of Public Health Genomics
Knowledge integration in public health genomics: evaluation of the epidemiologic evidence
April 19th, 2007 ~ Rockville, MD (ENVISION - Atlanta)

   
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EGAPP Working Group Meeting
April 30 – May 1, 2007 ~ Atlanta, Georgia

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Scientists implicate gene in Vitiligo and other autoimmune diseases”  This reference links to a non-governmental website
(Apr 10) NIH News reports, “In a study appearing in the March 22 New England Journal of Medicine, scientists supported by the National Institutes of Health’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered a connection between a specific gene and the inflammatory skin condition vitiligo, as well as a possible host of autoimmune diseases.”

“Massive Gene Screening Points Way To More Effective Chemotherapy”  This reference links to a non-governmental website
(Apr 12) Science Daily reports, “Using a technology that can quickly screen all 20,000-plus human genes for biological activity, scientists have isolated 87 genes that seem to affect how sensitive human cancer cells are to certain chemotherapy drugs.”

“Genes gang up to help cancer spread, study finds”  This reference links to a non-governmental website (last accessed 2/2008)
(Apr 11) Reuters Health reports, “Four genes gang up together to help cancer spread throughout the body, researchers said on Wednesday, including one affected by arthritis drugs.”

“Genetic makeup predicts recurrence of cancer”  This reference links to a non-governmental website
(Apr 10) Medical News Today reports, “Recently, there have been several advances in treatment and therapy for breast cancer.”

“Cigarettes, coffee may lower Parkinson's risk”
(Apr 10) Sun-Sentinel.com reports, “People who smoke cigarettes and drink lots of coffee are less likely to get Parkinson's disease than their family members who don't indulge in caffeine and nicotine, a new seven-year study shows.”

“New study zeroes in on the genetic roots of Alzheimer's”  This reference links to a non-governmental website
(Apr 10) OMRF reports, “Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer’s disease. Now a new study helps explain why this is so.”

“Study fails to verify gene variations as risk factors for certain cardiovascular problems”  This reference links to a non-governmental website
(Apr 10) EurekAlert! reports, “New research has failed to confirm findings from smaller studies that 85 gene variations are associated with an increased risk for acute coronary syndromes (ACS), which includes heart attack and a type of angina, according to a study in the April 11 issue of JAMA.”

“Study finds dietary fat interacts with genes”  This reference links to a non-governmental website
(Apr 10) EurekAlert! reports, “Research published in the Journal of Molecular Medicine examines how calories from fat, carbohydrate, and protein might interact with genes to affect body mass index (BMI), or body weight-for-height, and risk of obesity among adults in the Framingham Heart Study.”

“Gene may mark breast cancer patients who can skip chemotherapy”  This reference links to a non-governmental website
(Apr 9) Bloomberg.com reports, “The overactivity of a gene found in about 20 percent of women with breast cancer may identify those who can be treated without chemotherapy, researchers say.”

“Tackling TAR: Families cope with rare genetic disease”  This reference links to a non-governmental website
(Apr 9) Herald & Review reports, “Although they've never met, Kacey Derbort and Myshaun Dozier have a lot of things in common besides liking to talk.”

“Two brothers suffer from rare genetic disease”  This reference links to a non-governmental website
(Apr 9) wcco.com reports, “The University of Minnesota is one of three places in the country offering groundbreaking treatment for a rare genetic disease.” Video Link  This reference links to a non-governmental website

“Almac diagnostics announces pioneering genetic research on colorectal pre-malignancies”  This reference links to a non-governmental website
(Apr 8) Medical News Today reports, “Recently Almac Diagnostics announced a major study analysing colorectal polyp tissue samples using its novel Colorectal Cancer DSA™ microarray.”

“Discovery of gene mutation could improve treatment of eczema”  This reference links to a non-governmental website
(Apr 8) The Scotsman reports, “NEW discoveries in a gene linked to eczema could speed up new treatments for the condition, researchers believe.”

“New gene defect causes heavy bones”  This reference links to a non-governmental website
(Apr 7) Medical News Today reports, “Osteopetrosis is an inherited disorder whereby bones harden and become denser.”

“Genetic switch can control memory”  This reference links to a non-governmental website
(Apr 6) Science Daily reports, “McGill University researchers have discovered that a mutant gene improves the long-term memory of laboratory mice, a discovery they hope will one day lead to a better quality of life for Alzheimer’s patients and others suffering from memory impairment.”

“Spina bifida gene identified; groundbreaking research can make diagnosis easier”  This reference links to a non-governmental website
(Apr 5) Science Daily reports, “Researchers at McGill University have identified a gene that causes the debilitating developmental disorder spina bifida.”

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Genomics in Scientific Literature
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National population-based biobanks for genetic research
Swede H, et al.
Genet Med 2007 Mar;9(3):141-9

Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) Gene
Caldovic L, et al.
Hum Mutat 2007 Apr

Sporadic colorectal cancer and individual susceptibility: A review of the association studies investigating the role of DNA repair genetic polymorphisms
Naccarati A, et al.
Mutat Res 2007 Feb

Role of the COMT gene Val158Met polymorphism in mental disorders: A review
Hosak L
Eur Psychiatry 2007 Apr

Genetics of hypertrophic cardiomyopathy: one, two, or more diseases?
Bos JM, et al.
Curr Opin Cardiol 2007 May;22(3):193-9

DNA sequence variations of metalloproteinases: their role in asthma and COPD
Sampsonas F, et al.
Postgrad Med J 2007 Apr;83(978):244-50

Pharmacogenomics and its implications for autoimmune disease
Ross CJ, et al.
J Autoimmun 2007 Apr

Genetics, insurance and participation: How a Citizens' Jury reached its verdict
Bennett P & Smith SJ
Soc Sci Med 2007 Apr

National population-based biobanks for genetic research
Swede H, et al.
Genet Med 2007 Mar;9(3):141-9

The genetics of congenital heart disease: a review of recent developments
Weismann CG & Gelb BD
Curr Opin Cardiol 2007 May;22(3):200-6

A review of the genetics of essential hypertension
Binder A
Curr Opin Cardiol 2007 May;22(3):176-84

Family History
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 In The News

“Important news in the fight against breast cancer”  This reference links to a non-governmental website
(Apr 10) PR Newswire reports, “In its continuing fight against the disease, Susan G. Komen for the Cure is releasing “News for the Cure,” a series of educational video segments about breast cancer.”

 In The Scientific Literature

Population-based family case-control proband study on familial aggregation of metabolic syndrome: finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5)
Chiu YH, et al.
Diabetes Res Clin Pract 2007 Mar;75(3):348-56

Familial risk for gastric carcinoma: an updated study from Sweden
Hemminki K, et al.
Br J Cancer 2007 Apr

Factors associated with breast cancer-specific distress in younger women participating in a family history mammography screening programme
Henderson BJ, et al.
Psychooncology 2007 Apr

The contribution of familial and heritable risks in heart failure
Abdel-Qadir HM & Lee DS
Curr Opin Cardiol 2007 May;22(3):214-9

Effect of familial history and smoking on common cancer risks in Japan
Suzuki T, et al.
Cancer 2007 Apr

Genetic Testing
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 In The News

“No genetic link found for heart risk, study says”  This reference links to a non-governmental website
(Apr 10) Reuters reports, “Genetic testing failed to find any gene mutations that predict a higher risk of heart disease, a study released on Tuesday said.”

“Genetic disease tests for newborns ok'd”  This reference links to a non-governmental website
(Apr 5) Red Orbit reports, “A 28-gene signature that identifies breast cancer patients with higher chances of disease-free/overall survival has been found by U.S. doctors.”

 

 In The Scientific Literature

Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriersr
Llort G, et al.
Med Clin (Barc) 2007 Mar;128(12):468-76

Development, validation and application of tandem mass spectrometry for screening of inborn metabolic disorders in kuwaiti infants
Abdel-Hamid M, et al.
Med Princ Pract 2007;16(3):215-21

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 11, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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 Knowledge integration in public health genomics: evaluation of the epidemiologic evidence
 CDC's Public Health Genomics Monthly Seminar Series  
 April 19, 2007 ~ Rockville, MD (ENVISION - Atlanta, GA)

   
 

RNAi World Congress  This reference links to a non-governmental website
April 24-25, 2007 ~ Philadelphia, PA

   
 

5th National Forum for Heart Disease and Stroke Prevention  This reference links to a non-governmental website
April 25-27, 2007 ~ Washington, DC

   

Cancer Proteomics World Congress  This reference links to a non-governmental website
April 26-27, 2007 ~ Philadelphia, PA

   
 

Molecular Diagnostics World Congress  This reference links to a non-governmental website
April 26-27, 2007 ~ Philadelphia, PA

   
  NCI Symposium on Chromosome Biology  This reference links to a non-governmental website
April 26-27, 2007 ~ Bethesda, MD
   
New Listing 2nd ASM Conference on Integrating Metabolism and Genomics (IMAGE2)  This reference links to a non-governmental website
April 30 - May 3, 2007 ~ Montreal, Canada
   
New Listing Short Course: Cancer Epidemiology  This reference links to a non-governmental website
May 21-25, 2007 ~ Amsterdam, Netherlands

small triangle For a full listing of genetics and genomics-related events, please visit the 2007 Upcoming Events page.
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Let's Go Surfing
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Public Health Genomics Society (PHGS)  This reference links to a non-governmental website
The Public Health Genomics Society is an online community of professionals and students working to initiate collaborations across multiple fields, including public health, genomics, epidemiology, health economics, public policy, medicine, and environmental health.

Bioinformatics Platform  This reference links to a non-governmental website
The Bioinformatics Platform “provides services to Genome Canada funded initiatives through the Applied Genomics and Proteomic Research in Human Health Competition and Competition III projects, as well as other research initiatives around the world.”

International Society of Nutrigenetics/Nutrigenomics (ISNN)  This reference links to a non-governmental website
The International Society of Nutrigenetics/Nutrigenomics was established to “increase understanding through research and education of professionals and the general public of the role of genetic variation and dietary response and the role of nutrients in gene expression.”

 

 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: April 12, 2007 (archived document)
Content Source: National Office of Public Health Genomics