• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
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“Genetically Engineered Cells Can Transform Immune Cells Into Tumor Fighters In Humans”  (Sep 4) Medical News Today reports, “A team of researchers has genetically engineered normal immune cells to become specialized tumor fighters, demonstrating for the first time that these engineered cells can persist in the body and shrink large tumors in humans.”

“'Genetic horoscopes' build high hopes”
(Sep 7) Mail & Guardian Online reports, “This is the most important, most wondrous map ever produced by humankind." Thus said United States president Bill Clinton as he welcomed the unveiling of the draft sequence of the human genome -- the decoding of the three billion "letters" of DNA in our cells -- in March 2000.”

“Researchers seek genetic key to lymphoma”  (last accessed 2/2008)
(Sep 6) ABC NewOnline reports, “A Gold Coast academic says one of Australia's most common cancers is becoming even more prevalent.”

“Genetic secrets of human egg discovered”   (6.63KB)
(Sep 6) PhysOrg.com reports, “U.S. scientists say they have identified the genes that are unique to the human egg.”

“Researcher Studies Gene Families To Explore Diversity And Evolution” 
(Sep 5) Science Daily reports, “Theoretical biologist Stephen Proulx studies gene families to explore how genomes become diverse and evolve.”

“ExonHit Produces a New Map for Human Genome Expression as Well as Tools for its Study” 
(Sep 5) tickertech.com reports, “22,000 Genes can Express Over 200,000 Messenger RNAs, all Detected for the First Time Thanks to ExonHit's Self-Funded Research Activities.”

“Older fathers almost six times more likely to have autistic children” 
(Sep 5) News-Medical.Net reports, “Researchers in the U.S. have found that children fathered by older men have a higher risk of developing autism, possibly because of mutations or other genetic changes.”

“Party animal? Don't blame your genes” 
(Sep 5) abc.net reports, “Genes shape our health and appearance more than they shape our personality, suggests a new study of thousands of people in a genetically isolated part of the world.”

“Researchers identify genetic risk for type 1 diabetes” 
(Sep 4) News-Medical.Net reports, “A discovery at the Barbara Davis Center for Childhood Diabetes has identified a genetic risk for type 1 diabetes three to four times higher than previously thought possible.”

“Girl With a Fatal Genetic Disease Making Progress in a Clinical Trial” 
(Sep 3) Red Orbit reports, “When Elizabeth Lee Hallam was born on Sept. 29, 2003, she was a textbook example of the perfect baby.”

Pharmacogenetics and pharmacogenomics: development, science, and translation
Weinshilboum RM & Wang L
Annu Rev Genomics Hum Genet 2006;7:223-45

The Genetic Counseling Video Project (GCVP): Models of practice
Roter D, et al.
Am J Med Genet C Semin Med Genet 2006 Aug

Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis
Lejeune S, et al.
Hum Mutat 2006 Aug;27(10):1064

“UCLA study uncovers new risk factor for schizophrenia” 
(Sep 5) EurekAlert! reports, “UCLA scientists have discovered that infants who possess a specific immune gene that too closely resembles their mothers' are more likely to develop schizophrenia later in life.”

“Fight Back Against Inherited Sudden-Death Heart Condition” 
(Sep 5) newswise reports, “A combination of better diagnosis, treatment and genetic testing is starting to help people fight back against hypertrophic cardiomyopathy, an inherited condition that has the potential to cause sudden cardiac death.”

“Musician's cramp may run in families”  (last accessed 3/2007)
(Sep 1) Reuters Health via Medscape reports, “Musician's cramp, and other so-called focal task-specific dystonias, are typically thought of as sporadic or occupational conditions.”

Cancer Risk Assessment: Examining the Family Physician's Role
Tyler CV  & Snyder CW
J Am Board Fam Med 2006 Sep-Oct;19(5):468-77.

“Gene Test May Improve Breast Cancer Treatment” 
(Sep 6) Yahoo News reports, “A test that checks the expression of 70 genes associated with breast cancer can help doctors determine a patient's risk of cancer recurrence or death, an international study finds.”

“FDA releases draft guidelines regulating complex diagnostic tests”
(Sep 6) News-Medical.Net reports, “FDA on Tuesday released draft guidelines that assert the agency's authority for regulating gene- and protein-based diagnostic tests for conditions such as breast cancer and ovarian cancer, the Wall Street Journal reports.”

“Selection of embryos is on rise for couples” 
(Sep 3) International Herald Tribunr reports, “As Chad Kingsbury watches his daughter playing in the sandbox behind their Chicago house, the thought that has flashed through his mind a million times in her two years of life comes again: Chloe will never be sick.”

Perceived genetic knowledge, attitudes towards genetic testing, and the relationship between these among patients with a chronic disease
Morren M, et al.
Patient Educ Couns 2006 Aug

Cost-effectiveness of 4 Neonatal Screening Strategies for Cystic Fibrosis
van den Akker-van Marle ME, et al.
Pediatrics 2006 Sep;118(3):896-905

A recessive Mendelian model to predict carrier probabilities of DFNB1 for nonsyndromic deafness
Gonzalez JR, et al.
Hum Mutat 2006 Aug

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 6, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

National Coordinating Center for the Genetics and Newborn Screening Regional Collaborative
Groups  
It works to strengthen and support the genetics and newborn screening (NBS) capacity of the States and, therefore, the Nation, using a regional approach to addressing maldistribution of genetic services and resources.

Human (Homo sapiens) Genome Browser Gateway  
The UCSC Genome Browser was created by the Genome Bioinformatics Group of UC Santa Cruz  . The Genome Browser zooms and scrolls over chromosomes, showing the work of annotators worldwide.