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 Thursday, May 11, 2006     Volume 16   Number 19  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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collage of images in a circle At A Glance CDC's Office of Genomics and Disease Prevention
Presents an overview of public health genomics at CDC.
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CDC Announcements
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CDC sponsored material New HuGE Review
The epidemiology of medium chain acyl-CoA dehydrogenase deficiency: An update you will need a free Acrobat reader to view this file (111KB)
Scott Grosse et al. Genetics in Medicine (April 2006)
   
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Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now, space is limited.
   
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What’s New in HuGENet™
May 2006
 
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Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature DatabaseThis reference links to a non-governmental website 
Lin, B. et al. American Journal of Epidemiology

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Broad Institute scientists awarded $18M CARE grant” This reference links to a non-governmental website 
(May 4) EurekAlert! reports, “The Broad Institute of MIT and Harvard announced today an award from the National Heart, Lung, and Blood Institute (NHLBI) for more than $18M to support genomic studies aimed at unveiling the genetic variations that underlie common human diseases.”

“Human Genetics May Play a Role in Avian Flu Cases” This reference links to a non-governmental website 
(May 11) The Jakarta Post reports, “Some people are more susceptible to bird flu than others, suggesting human genetics may play a role in the viral infection that's killed more than 100 people in the pastthree years, virologist Robert Webster said.”

“Gene amplification could guide treatment for high-risk breast cancer” This reference links to a non-governmental website 
(May 11) News-Medical.Net reports, “A new study shows that breast cancer patients with an "amplification," or greater number of copies, of the TOP2A gene are 45% more likely than women who do not have this amplification to benefit from a longer course of anthracycline-based adjuvant chemotherapy.”

“Extension of embryo screening will help reduce serious illness” This reference links to a non-governmental website 
(May 11) News-Medical.Net reports, “A fertility watchdog in Britain, the Human Fertilisation and Embryology Authority (HFEA), has given approval for the extension of embryo screening to cover a wider range of mutated genes, in the main those which raise the risk of cancer in later life.”

“Genes Hunters Tracking The Tumour - 2nd IFOM-IEO Campus Meeting On Cancer”This reference links to a non-governmental website 
(May 10) Medical News Today reports, “What is the best strategy to determine the specific function of a gene?”

“Gene "CGI-58" linked to rare disease activates fat breakdown”This reference links to a non-governmental website 
(May 10) News-Medical.Net reports, “A gene earlier linked to a rare disease plays a critical role in the body's "finely tuned balance" of fat storage and break down, new evidence reported in the May Cell Metabolism reveals.”

“Scientists detect cancer genes with new algorithm”This reference links to a non-governmental website 
(May 10) News-Medical.Net reports, “Researchers at New York University's Courant Institute of Mathematical Sciences have developed a new algorithm that enhances the ability to detect a cancer gene, and have applied their algorithm to map the set of tumor-suppressor genes involved in lung cancer.”

“Genetic disease detectable, doctors say”This reference links to a non-governmental website 
(May 9) Taiwan News reports, “Thalassemia, an inherited disease of the red blood cells, is the most common form of rare genetic disease in Taiwan.”

“Effective gene suppression using small interfering RNA in hard-to-transfect human T cells”This reference links to a non-governmental website 
(May 9) News-Medical.Net reports, “A technical advance in laboratory techniques may provide biology researchers broader access to RNA interference, a process of blocking the activity of targeted genes.”

“Europe wide study to examine causes of asthma”This reference links to a non-governmental website 
(May 9) EurekAlert! reports, “Imperial College London and Ludwig-Maximilians-Universität (LMU) Munich are to take the lead in a Euro 11 million (GBP 8 million) study to examine how genetics and environment influence the development of asthma in Europe.”

“NYU algorithm enhances ability to detect cancer genes”This reference links to a non-governmental website 
(May 9) EurekAlert! reports, “Researchers at New York University's Courant Institute of Mathematical Sciences have developed a new algorithm that enhances the ability to detect a cancer gene, and have applied their algorithm to map the set of tumor-suppressor genes involved in lung cancer.”

“Junk" RNA regulates important cellular processes”This reference links to a non-governmental website 
(May 9) News-Medical.Net reports, “It has been known for a long time that much of a cell's RNA stems from DNA regions called intergenic spacers (IGS) that lie between two genes and do not code for proteins.”

“Genetic variants and breast cancer risk, genetics and suicidal behavior, and more”This reference links to a non-governmental website 
(May 8) EurekAlert! reports, “Remember BRCA1, APC, and p53? The association between rare variants in those genes and familial breast cancer, colon cancer, and multiple cancers, respectively, had been reported over 10 years ago.”

“Gene mutation causes multiple birth defects”This reference links to a non-governmental website 
(May 8) myDNA reports, “The transition from fertilized egg to newborn baby requires an incredibly complex network of genes, proteins and biochemical signals that scientists are only beginning to understand.”

“Iceland's Decode finds prostate cancer risk gene” 
(May 8) Reuters Health reports, “Scientists at Iceland's Decode Genetics Inc have discovered a genetic variant that may account for around 8 percent of prostate cancer cases, marking a step forward in understanding the disease.”

“Mutation In Deafness Gene Can Help Heal Wounds And Prevent Infection”This reference links to a non-governmental website 
(May 8) Medical News Today reports, “A mutation in a gene commonly associated with deafness can play an important part in improving wound healing, a scientist told the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands, today (Monday 8 May 2006).”

“New approaches to genetic disease, based on cells' own ability to correct themselves”This reference links to a non-governmental website 
(May 8) News-Medical. Net reports, “New approaches to genetic disease, based on cells' own ability to correct themselves, will be outlined today at the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands.”

“Novel protein JHDM2A offers new look at male hormone regulation”This reference links to a non-governmental website 
(May 8) News-Medical. Net reports, “For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.”

“UCSD researchers link novel mutated gene to meal retardation and imbalance”This reference links to a non-governmental website 
(May 7) EurekAlert! reports, “The research team, directed by Joseph Gleeson, M.D., Director of the Neurogenetics Laboratory at the UCSD School of Medicine and associate professor in the Department of Neurosciences, have identified a new gene that, when mutated, leads to JSRD.”

“Expanding Waistlines Triggered By Your Genes”This reference links to a non-governmental website 
(May 6) Science Daily reports, “A gene that degrades the body's collagen infrastructure has been shown to make fat cells fatter and expand girth.”

“Gene That Shuts Down Immune System Found In 20 Percent Of People Of African Descent”This reference links to a non-governmental website 
(May 6) Science Daily reports, “In a groundbreaking new study published in the prestigious journal Nature this week, the team that first discovered the role of caspase-12 in humans has now uncovered the mechanism by which it sabotages us, allowing researchers to develop methods to counter its damaging effects.”

“Molecular Security Mechanism For Keeping Mutations In Check”This reference links to a non-governmental website 
(May 5) Science Daily reports, “Everyone knows mutations -- genetic mistakes in DNA, the material of heredity -- are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing.”

“Concern over differences in genetic databases”This reference links to a non-governmental website 
(May 5) Laboratorytalk reports, “Inconsistencies among a growing number of genetic databases could lead to misdiagnoses of genetic disorders by health care providers, according to a study that appears in the latest issue of Cytogenetic and Genome Research.”

“Therapeutic Gene Suspected To Cause Cancer”This reference links to a non-governmental website 
(May 5) Medical News Today reports, “One of the few gene therapy studies that had ever been successful was terminated in 2003, because several of the treated children had developed leukemia.”

“Genetics might explain why some people get bird flu” 
(May 5) Reuters reports, “People who have been infected with the H5N1 bird flu virus might be genetically predisposed to infection by avian viruses, leading disease experts suggested on Thursday.”

“Bold Three-Stage Brain Operation for Intractable Seizures Appears Promising”This reference links to a non-governmental website 
(May 4) NYU Medical Center reports, “Sadly, none of the treatments for epilepsy—anti-seizure medications, a procedure called vagus nerve stimulation, a special diet —could quell the electrical storms in the young boy’s brain.”

“Diabetes gene at root of wider syndrome”This reference links to a non-governmental website 
(May 4) hum-molgen news alert reports, “British scientists say gene mutations associated with neonatal diabetes are believed responsible for other neurological dysfunctions.”

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Genomics in Scientific Literature
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Genes and Chronic Fatigue: How Strong Is the Evidence? This reference links to a non-governmental website
Kaiser J
Science 2006 May;312(5774):669 - 671

Expanding nurses' roles in telemedicine & genetics services
Lea DH
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):185-9

Parental experience of a pediatric genetic referral
Skirton H
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):178-84

Genetic influences on preterm birth
Giarratano G
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):169-75

Newborn screening policy in the United kingdom & the United States:two different communities of practice
Patch C
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):164-8

Issues in genetic testing of children
Twomey JG
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):156-63

Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics
Lewis JA, et al.
MCN Am J Matern Child Nurs 2006 May-2006 Jun;31(3):146-53

Family history of early-onset cardiovascular disorders is associated with a higher risk of severe preeclampsia
Rigo J Jr, et al.
Eur J Obstet Gynecol Reprod Biol 2006 May

Recent advances in the genetics of osteoporosis
Williams FM & Spector TD
J Musculoskelet Neuronal Interact 2006 Mar;6(1):27-35

Case-parent Triads: Estimating Single- and Double-dose Effects of Fetal and Maternal Disease Gene Haplotypes
Gjessing HK & Lie RT
Ann Hum Genet 2006 May;70(Pt 3):382-96

Multiple imputation of missing genotype data for unrelated individuals
Souverein OW, et al.
Ann Hum Genet 2006 May;70(Pt 3):372-81

Appropriate use of information on family history of disease in recruitment for linkage analysis studies
Wallace C & Clayton DG
Ann Hum Genet 2006 May;70(Pt 3):360-71

A comparison of individual genotyping and pooled DNA analysis for polymorphism validation prior to large-scale genetic studies
Yang HC, et al.
Ann Hum Genet 2006 May;70(Pt 3):350-9

Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: sample size and power calculations
Hanson RL, et al.
Ann Hum Genet 2006 May;70(Pt 3):332-49

Genetic variation in genes of folate metabolism and neural-tube defect risk
van der Linden IJ, et al.
Proc Nutr Soc 2006 May;65(2):204-15

Clinical applications of bioinformatics, genomics, and pharmacogenomics
Iqbal O & Fareed J
Methods Mol Biol 2006;316:159-77

Omnibus permutation tests of the association of an ensemble of genetic markers with disease in case-control studies
Potter DM
Genet Epidemiol 2006 May

Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
Schmidt S, et al.
Genet Epidemiol 2006 May

GENOMIZER: an integrated analysis system for genome-wide association data
Franke A, et al.
Hum Mutat 2006 May

Does familiarity breed acceptance? The influence of policy on physicians' attitudes toward newborn screening programs
Koopmans J & Ross LF
Pediatrics 2006 May;117(5):1477-85

Views of female breast cancer patients who donated biologic samples regarding storage and use of samples for genetic research
Kaphingst KA, et al.
Clin Genet 2006 May;69(5):393-8

Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening
Andreassi MG, et al.
Clin Chem Lab Med 2006;44(5):514-21

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 10, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Condition
 

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week 8th International Meeting "Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases"
November 30 - December 4, 2006 ~ Bangkok, Thailand
  Second American Congress of Epidemiology
June 21-24, 2006 ~ Seattle, WA
   
  Scandinavian Institute in Statistical GeneticsThis reference links to a non-governmental website
July 24-28, 2006 ~ University of Aarhus ~ Aarhus, Denmark
   
  11th International Congress of Human GeneticsThis reference links to a non-governmental website
August 6-10, 2006 ~ Brisbane, Australia
   
  British Society for Human Genetics (BSHG) Annual ConferenceThis reference links to a non-governmental website
September 18-20, 2006 ~ York, UK
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Let's Go Surfing
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Family History and Your Health Newsletter This reference links to a non-governmental website 
Michigan Department of Community Health, May 2006

Public Health Genetics Unit, UK, Newsletter, May 2006This reference links to a non-governmental website
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health implications.

Genetic Interest GroupThis reference links to a non-governmental website 
The Genetic Interest Group (GIG) is a national alliance of patient organisations with a membership of over 130 charities which support children, families and individuals affected by genetic disorders.
 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: May 11, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics