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 Thursday, March 23, 2006     Volume 16   Number 12  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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CDC Public Health Genomics Collaboration

CDC’s Public Health Genomics Collaboration
March 17, 2006

CDC’s Office of Genomics and Disease Prevention conducted an inaugural meeting to discuss the Public Health Genomics Collaboration—a new network of CDC professionals working or interested in public health genomics. The full agenda and PowerPoint presentations are now available.

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CDC Announcements
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(March, 2006) HuGENet™ releases the first edition of the HuGENet™ Handbook of Systematic Reviews. This reference links to a non-governmental websiteLink here to download free  Adobe Reader (167KB) This document has extensive guidance for integrating evidence on gene-disease associations, types of systematic reviews and complete set of points to consider for conducting such reviews.

   
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From public health emergency to public health services: the implications for evolving criteria for newborn screening panels
Grosse S. et al. Pediatrics March 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Study identifies patients at risk for sudden cardiac death” This reference links to a non-governmental website
(March 21) News Medical.net reports, “Researchers have found a more accurate way to tell which children and teenagers are likely to be among the thousand or so who suddenly die each year in the United States from genetic heart conditions that cause arrhythmia, according to a study presented at the American College of Cardiology annual meeting and selected for expedited publication in the Journal of the American College of Cardiology (JACC).”

“Mutated gene found to lower 'bad cholesterol' in lucky few” This reference links to a non-governmental website
(March 23) Life Science News reports, “About 3 percent of the U.S. population has a genetic mutation that lowers so-called "bad cholesterol" and offers sharply higher protection against heart disease, scientists in Houston and Dallas report in a study published today.”

“Remaining 80% of breast cancer genes may soon be discovered” This reference links to a non-governmental website
(March 23) News Medical.net reports, “We are closer to finding the missing 80% of breast cancer genes than ever before thanks to the success of the COSMIC database (Catalogue Of Somatic Mutations In Cancer) the 5th European Breast Cancer Conference (EBCC-5) was told today.”

“Looks like we've all inherited the messy gene” This reference links to a non-governmental website
(March 22) The Seattle Times reports, “It was a nice idea that we're all genetically 99.9 percent identical, but new research says it's not so simple.”

“Human genes may kill HIV” This reference links to a non-governmental website
(March 22) Advocate.com reports, “A study in Proceedings of the National Academy of Sciences suggests that two key human genes may have the ability to destroy HIV genetic material inside immune system cells.”

“Quitting Smoking Strongly Decreases Risk Of Death And Preventive Strategies For Women With Gene Mutations That Increase The Risk Of Breast Cancer” This reference links to a non-governmental website
(March 22) Medical News Today reports, “1. New Large Study of Men and Women: Smoking Strongly Increases Risk for Death in Middle Age, Quitting Strongly Decreases Risk of Death, Even at Older Ages.”

“A Hunt for Genes That Betrayed a Desert People” This reference links to a non-governmental website
(March 21) The New York Times reports, “In a sky blue bedroom they share but rarely leave, a young sister and brother lie in twin beds that swallow up their small motionless bodies, victims of a genetic disease so rare it does not even have a name.”

“The role of evolutionary genomics in the development of autism” This reference links to a non-governmental website
(March 21) EurekAlert! reports, “Scientists at the London School of Economics, UK and Simon Fraser University, Canada have described the first hypothesis grounded in evolutionary genomics explaining the development of autism.”

“Tests can miss BRCA mutations” This reference links to a non-governmental website
(March 21) myDNA reports, “Despite a negative (normal) genetic test for mutations in the BRCA1 and BRCA2 genes, about 12 percent of breast cancer patients from high-risk families carried previously undetected cancer-associated mutations, according to a study in the March 22/29 issue of The Journal of the American Medical Association (JAMA), a theme issue on women's health.”

“Eczema And Asthma Hope For Millions As Gene Defect Identified” This reference links to a non-governmental website
(March 21) Medical News Today reports, “Researchers, led by a team at Dundee University, UK, have identified a gene defect responsible for eczema and asthma.”

“Gene linked to impulsive violence weakens brain circuits that regulate thinking in humans” This reference links to a non-governmental website
(March 21) News Medical.net reports, “A version of a gene previously linked to impulsive violence appears to weaken brain circuits that regulate impulses, emotional memory and thinking in humans, researchers at the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) have found.”

“Gene, Smoking Combo Boosts Risk of Elderly Vision Loss”
(March 20) Medline Plus reports, “A combination of smoking plus a specific gene variant could account for a third of cases of age-related macular degeneration (AMD), researchers say.”

“Gene Influences Antidepressant Response” This reference links to a non-governmental website
(March 20) Medical News Today reports, “Whether depressed patients will respond to an antidepressant depends, in part, on which version of a gene they inherit, a study led by scientists at the National Institutes of Health (NIH) has discovered.”

“H5N1 influenza virus is undergoing genetic diversity expansion” This reference links to a non-governmental website
(March 20) News Medical.net reports, “An analysis of H5N1 influenza samples in Southeast Asia shows not only how the two strains that have caused human disease are related but also that they belong to two different, distinct genetic subgroups.”

“Molecule By Molecule, New Assay Shows Real-time Gene Activity”
(March 19) Medical News Today reports, “Chemists at Harvard University have developed the first technique providing a real-time, molecule-by-molecule "movie" of protein production in live cells.”

“Gene changes found in Vietnam's Agent Orange victims” This reference links to a non-governmental website
(March 17) China View reports, “Vietnamese scientists have found that genes of some local people affected by Agent Orange, defoliants sprayed by U.S. Army in the Vietnam War, have been altered, said a symposium delegate.”

“Targeted Genetics Amends tgAAC94 Clinical Protocol and Advances Ongoing Trial to Phase I/II; Amendment Potentially Accelerates Clinical Development Of Therapy” This reference links to a non-governmental website
(March 17) dBusiness News reports, “Targeted Genetics Corporation (Nasdaq:TGEN), a developer of molecular therapies for the prevention and treatment of acquired and inherited diseases, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) to amend the clinical protocol of its ongoing Phase I trial of tgAAC94 in patients with inflammatory arthritis.”

“Bioterror Agent Sarin Causes Long-Term Genetic Damage”
(March 16) Medline Plus reports, “The toxic chemical sarin, a potential bioterrorism agent, causes devastating, long-term damage to genes controlling memory, mood, thinking, muscle control and numerous other brain functions, U.S. researchers report.”

“Gene test helps predict lung cancer, study finds” This reference links to a non-governmental website (last accessed 2/2008)
(March 16) Reuters reports, “A test that finds damaged genes in the lungs of people considered at high risk of lung cancer might be able to predict who actually develops the deadly disease, U.S. researchers said on Wednesday.”

“U-M scientists identify major psoriasis susceptibility gene” This reference links to a non-governmental website
(March 16) Innovations Report reports, “University of Michigan scientists have found a common genetic variation in an immune system gene that makes people much more likely to develop psoriasis – a disfiguring inflammatory skin disease.”

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Genomics in Scientific Literature
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Mendelian disorders deserve more attention
Antonarakis SE & Beckmann JS
Nat Rev Genet 2006 Apr;7(4):277-82

Genetic epidemiology of type 1 diabetes
Paterson AD
Curr Diab Rep 2006 Apr;6(2):139-46

A genetic model for determining MSH2 and MLH1 carrier probabilities based on family history and tumor microsatellite instability
Marroni F, et al.
Clin Genet 2006 Mar;69(3):254-62

Genetic knowledge and moral responsibility: ambiguity at the interface of genetic research and clinical practice
Pullman D & Hodgkinson K
Clin Genet 2006 Mar;69(3):199-203

Case-control and case-only designs with genotype and family history data: estimating relative risk, residual familial aggregation, and cumulative risk
Chatterjee N, et al.
Biometrics 2006 Mar;62(1):36-48

Haplotype-based association analysis in cohort and nested case-control studies
Chen J & Chatterjee N
Biometrics 2006 Mar;62(1):28-35

Discovering the Family History of Huntington Disease (HD)
Etchegary H
J Genet Couns 2006 Mar

The genetics of nicotine dependence
Li MD
Curr Psychiatry Rep 2006 Apr;8(2):158-64

The genetics of alcohol dependence
Dick DM & Bierut LJ
Curr Psychiatry Rep 2006 Apr;8(2):151-7

Information of family members with an increased risk for a genetic predisposition
Gordijn B
Dtsch Med Wochenschr 2006 Mar;131(11):573-6

Use of phenotypic covariates in association analysis by sequential addition of cases
Macgregor S, et al.
Eur J Hum Genet 2006 Mar

Genetics of Parkinson disease: paradigm shifts and future prospects
Farrer MJ
Nat Rev Genet 2006 Apr;7(4):306-18

Breast Cancer Screening, Outside the Population-Screening Program, of Women from Breast Cancer Families without Proven BRCA1/BRCA2 Mutations: a Simulation Study
Jacobi CE, et al.
Cancer Epidemiol Biomarkers Prev 2006 Mar;15(3):429-36

Hereditary hemochromatosis: screening and management
Waalen J & Beutler E
Curr Hematol Rep 2006 Mar;5(1):34-40

Genetic epidemiology and primary care
Smith BH, et al.
Br J Gen Pract 2006 Mar;56(524):214-21

The Use of Random Controls in Genetic Association Studies
Garner C
Hum Hered 2006 Mar;61(1):22-6

Satisfaction with genetic counseling for BRCA1 and BRCA2 mutations among African American women
Charles S, et al.
Patient Educ Couns 2006 Mar

The perceived personal control (PPC) questionnaire as an outcome of genetic counseling: Reliability and validity of the instrument
Smets EM, et al.
Am J Med Genet A 2006 Mar

The power to detect disease associations with mitochondrial DNA haplogroups
Samuels DC, et al.
Am J Hum Genet 2006 Apr;78(4):713-20

An Evaluation of the Performance of Tag SNPs Derived from HapMap in a Caucasian Population
Montpetit A, et al.
PLoS Genet 2006 Mar;2(3):e27

Genetic variants predisposing to cardiovascular disease
Visvikis-Siest S & Marteau JB
Curr Opin Lipidol 2006 Apr;17(2):139-51

Postprandial lipoprotein metabolism, genes and risk of cardiovascular disease
Lopez-Miranda J, et al.
Curr Opin Lipidol 2006 Apr;17(2):132-8

A Bayesian toolkit for genetic association studies
Lunn DJ, et al.
Genet Epidemiol 2006 Mar;30(3):231-47

Medical students' attitudes toward genetic testing of minors
Riordan SH & Loescher LJ
Genet Test 2006 Spring;10(1):68-73

Genetic Testing for Huntington's Disease: How Is the Decision Taken?
Etchegary H
Genet Test 2006 Spring;10(1):60-7

Predictors of belief that genetic test information about hemochromatosis should be shared with family members
Tucker DC, et al.
Genet Test 2006 Spring;10(1):50-9

Quality of Life and its Relation to Cancer-Related Stress in Women of Families with Hereditary Cancer without Demonstrated Mutation
Geirdal AO, et al.
Qual Life Res 2006 Apr;15(3):461-70

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 22, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

2006 Genetic Alliance Conference: Celebrating 20 years of Excellence in Advocacy This reference links to a non-governmental website
July 28-30, 2006 ~ Bethesda, MD
New this week

"Pharmacogenetics: Individual Genetic Responses to Drugs and Medications" Symposium
April 7, 2006 ~ Baltimore, MD

   
  Third International Conference GENOMICS & SOCIETY
April 20-21, 2006 ~ Amsterdam, Netherlands
   
New this week
International Symposium on the Comparative Biology of the Alpha-proteobacteria This reference links to a non-governmental website
April 26-29, 2006 ~ Blacksburg, Virginia
   
New this week Fourth International RNAi-2006-Boston Meeting on RNA interference: Biochemical Genetics to Drugs & Therapeutics
May 1-3, 2006 ~ Waltham, MA
   
  HUGO's 11th Human Genome Meeting This reference links to a non-governmental website
May 31 - June 3, 2006 ~ Helsinki, Finland
   
New this week British Society for Human Genetics (BSHG) Annual Conference This reference links to a non-governmental website
September 18-20, 2006 ~ York, UK
   
New this week HuGENet Short Course This reference links to a non-governmental website
November 6-8, 2006 ~ Cambridge, UK
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Let's Go Surfing
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British Society for Human Genetics (BSHG) This reference links to a non-governmental website
Provides a forum for professionals involved in Genetics as a clinical service and research.

Putting DNA to Work This reference links to a non-governmental website
The National Academy of Sciences provides this multimedia interactive webpage where one can explore some of the applications of DNA technology.

A Hypermedia Glossary of Genetic Terms This reference links to a non-governmental website
A glossary of genetic terms with pictures and links; search results also show the context sensitive meaning of the related terms.

GenePool This reference links to a non-governmental website
This library aims to provide high quality, clinically useful information for health professionals about clinical genetics: diagnosis, risk assessment and management of genetic conditions.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: March 23, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics