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 Thursday, June 29, 2006     Volume 16   Number 26  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

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CDC Announcements
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Genetic testing for susceptibility to breast and ovarian cancer: Evaluating the impact of a direct-to-consumer marketing campaign on physicians’ knowledge and practices (2006)
Melanie F. Myers, et al. Genetics in Medicine;8(6):361-370.

   
CDC sponsored material Storage and use of residual dried blood spots from state newborn screening programs
Olney RS, et al.
J Pediatr 2006 May;148(5):618-22
   
CDC sponsored material

New HuGE Case Studies

CDC sponsored material HuGE What's New
June 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Gene-regulating enzyme is also a target for anti-depressive drugs” This reference links to a non-governmental website
(June 23) EurekAlert! reports, “In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells.”

“A candidate gene for familial idiopathic pulmonary fibrosis identified” This reference links to a non-governmental website
(June 28) EurekAlert! reports, “ELMOD2-gene is a prime candidate gene for familial idiopathic pulmonary fibrosis, suggests the recent study published by the researchers at the University and University Hospital of Helsinki, Finland.”

“Speeding discovery of the 'human cancer genome'” This reference links to a non-governmental website
(June 28) EurekAlert! reports, “Two gene discoveries announced in separate reports in the June 30, 2006 issue of Cell highlight one way to speed through the human genome in search of those genes most important for spawning cancer.”

“Genes screen to spot cancer risk” This reference links to a non-governmental website
(June 28) BBC News reports, “Scientists in Edinburgh have developed a new test to find out which groups of people are more likely to develop bowel cancer.”

“UCI's gene machine” This reference links to a non-governmental website
(June 27) ocregister.com reports, “Two university professors formed CODA Genomics, a startup that combines biology and computer science to create and repair genetic building blocks.”

“Can genes explain rising obesity?” This reference links to a non-governmental website
(June 27) BBC News reports, “Contrary to conventional wisdom, the obesity epidemic is not restricted to people in Western countries who eat bad diets and are not very active.”

“India to have national repository on human genetic resource and data soon” This reference links to a non-governmental website
(June 27) Pharmabiz.com reports, “The unique genetic diversity of Indian population, a major attraction for the drug discovery organizations looking for conducting clinical trials in the country, may soon to be well recorded in a national repository on human genetic resource.”

"Improving Drug Treatment by Understanding Genetic” This reference links to a non-governmental website
(June 27) Scoop reports, “Researchers from around the country are converging on Christchurch ( Wed. June 28) for a scientific symposium on pharmacogenomics, an emerging area of innovative health research that seeks to understand how differences in genetic makeup can affect an individual's response to drugs.”

“Markers Of Gene, Protein, Or Micro-Rna Activity Predict Outcome In Prostate And Colorectal
Cancers”
This reference links to a non-governmental website
(June 27) New Materials International reports, “Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome.”

“3 new genes implicated in rheumatoid arthritis” This reference links to a non-governmental website
(June 27) News-Medical.net reports, “Researchers continue to search for genetic clues into rheumatoid arthritis (RA), a chronic inflammatory joint disease.”

“X-rays increase breast cancer risk” This reference links to a non-governmental website
(June 27) News-Medical.net reports, “According to new research X-rays may significantly increase the risk of breast cancer in women who are genetically susceptible to the disease.”

“Extensive regulations make research difficult” This reference links to a non-governmental website
(June 26) News-Medical.net reports, “According to Norway's functional genomics researchers, it has become more difficult in recent years to begin research projects based on genetic samples from patients from hospitals or participants in health surveys.”

“Gene Therapy and Your Child”
(June 26) Yahoo News reports, “Gene therapy carries the excitement of a cure-all for a host of diseases, the controversy surrounding the altering of human genes, and the promise of a type of medical treatment most of us would never imagine possible.”

“'Superbug' yields genetic secrets” This reference links to a non-governmental website
(June 26) Times Online reports, “THE genetic code of one of the most stubborn of all hospital “superbugs” has been mapped by British scientists, promising new ways of treating and preventing an infection that is implicated in more than 2,000 deaths each year.”

“Dana Farber and 454 life sciences announce breakthrough in DNA sequencing for cancer research”
(June 25) EurekAlert! reports, “454 Life Sciences Corporation, a majority-owned subsidiary of CuraGen Corporation (Nasdaq: CRGN), in collaboration with scientists at Dana Farber Cancer Center and Broad Institute, today reported a new method for the detection of cancer gene mutations present at extremely low levels.”

“British Researchers Announce Development Of Rapid, Broad Genetic Testing Technique Of
Embryos”
This reference links to a non-governmental website
(June 22) Medical News Today reports, “A team of British researchers on Monday announced they have developed a test that can rapidly detect certain genetic conditions in human embryos by looking for DNA "markers" or "fingerprints," Reuters reports (Reaney, Reuters, 6/18).”

“Three human gene variants appear to influence tb susceptibility” This reference links to a non-governmental website
(June 22) EurekAlert! reports, “Three variations of a human gene appear to impact human tuberculosis susceptibility, providing insight into why some patients infected with the Mycobacterium tuberculosis pathogen develop the full-blown disease and others do not.”

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Genomics in Scientific Literature
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Public attitudes toward genetic testing: perceived benefits and objections
Henneman L, et al.
Genet Test 2006 Summer;10(2):139-45

Attitudes towards predictive genetic testing for Alzheimer's disease
Illes F, et al.
Z Gerontol Geriatr 2006 Jun;39(3):233-9

Genetic susceptibility to type 1 diabetes mellitus in humans
Kantarova D & Buc M
Physiol Res 2006 Jun

Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis
Szolnoki Z & Melegh B
Curr Med Chem 2006;13(14):1627-34

A quality assessment survey of SNP genotyping laboratories
Lahermo P, et al.
Hum Mutat 2006 Jun;27(7):711-4

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease
Martins IJ, et al.
Mol Psychiatry 2006 Jun

Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment
Lee AM & Tyndale RF
J Psychopharmacol 2006 Jul;20(4 Suppl):7-14

Psychological impact of genetic counseling for familial cancer: a systematic review and meta-analysis
Braithwaite D, et al.
Fam Cancer 2006;5(1):61-75

Genetics of hereditary diffuse gastric cancer: progress and future challenges
Suriano G, et al.
Future Oncol 2006 Jun;2(3):363-70

Genomics in breast and prostate cancer: assessment of the current state and future perspectives
Mehrian-Shai R & Reichardt JK
Future  Oncol 2006 Jun;2(3):357-62

Family history of dementia is a risk factor for Lewy body disease
Woodruff BK, et al.
Neurology 2006 Jun;66(12):1949-50

Factors associated with colorectal cancer risk perception: the role of polyps and family history
Stark JR, et al.
Health Educ Res 2006 Jun

The Genetics of Asthma: ADAM33 as an Example of a Susceptibility Gene
Holgate ST, et al.
Proc Am Thorac Soc 2006 Jul;3(5):440-3

Progress in chronic obstructive pulmonary disease genetics
Silverman EK
Proc Am Thorac Soc 2006 Jul;3(5):405-8

Cold climate genes and the prevalence of type 2 diabetes mellitus
Fridlyand LE & Philipson LH
Med Hypotheses 2006 Jun

Parkinson's disease and family history
Sellbach AN, et al.
Parkinsonism Relat Disord 2006 Jun

The association between apolipoprotein E and multiple sclerosis
Pinholt M, et al.
Eur J Neurol 2006 Jun;13(6):573-80

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 28, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

Secretary’s Advisory Committee on Genetics, Health, and Society’s Eleventh Meeting
November 13-14, 2006 ~ Adelphi, MD

 

Genomic Perspectives to Host Pathogen Interactions This reference links to a non-governmental website (last accessed 2/2008)
September 7-10, 2006 ~ Cold Spring Harbor, NY

   
New This Week ABC Transporters and Genetic Disease This reference links to a non-governmental website
September 28-29, 2006 ~ Frederick, MD
   
  The American Society of Human Genetics 56th Annual Meeting This reference links to a non-governmental website
October 9-13, 2006 ~ New Orleans, Lousiana
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Let's Go Surfing
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Program in Public Health Genetics This reference links to a non-governmental website (last accessed 2/2008)
University of Iowa College of Public Health

Department of Molecular and Human Genetics This reference links to a non-governmental website
Baylor College of Medicine

Understanding Genetics This reference links to a non-governmental website
Tech Innovation Museum

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: June 29, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics