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 Thursday, June 22, 2006     Volume 16   Number 25  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

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CDC Announcements
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CDC sponsored material

Genetic testing for susceptibility to breast and ovarian cancer: Evaluating the impact of a direct-to-consumer marketing campaign on physicians’ knowledge and practices (2006)
Melanie F. Myers, et al. Genetics in Medicine;8(6):361-370.

   
CDC sponsored material

New HuGE Case Studies

   
CDC sponsored material HuGE What's New
June 2006
   
CDC sponsored material

New HuGE Review
Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism: A HuGE Review and Meta-Analysis pdf only(169KB)
Philip S. Wells et al.  American Journal of Epidemiology (June 2006)

   
CDC sponsored material New HuGE Review
XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer PDF only (3.0MB / Web tables included)
Maurizio Manuguerra et al. American Journal of Epidemiology Advance Access (May 2006)
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“CHAVI announces international search for genes affecting HIV response” This reference links to a non-governmental website 
(June 20) EurekAlert! reports, “A pioneering collaboration among U.S., European and Australian researchers announced June 20, 2006, will seek to identify genetic differences in the way people respond to HIV.”

“Mutant Gene May Help Cause Abnormal Heartbeat” This reference links to a non-governmental website
(June 22) HeartInfo.org reports, “A genetic flaw may help trigger atrial fibrillation, the dangerous abnormal heartbeat whose cause has long remained a mystery.”

“PTPN22 gene associated with both susceptibility and disease progression in rheumatoid arthritis” This reference links to a non-governmental website
(June 22) EurekAlert! reports, “New research, announced today at the 7th EULAR annual congress, reveals the Protein Tyrosine Phosphatase N22 (PTPN22) gene is associated not only with rheumatoid arthritis (RA) disease susceptibility, but also with disease progression, according to researchers from Norway and the Netherlands.”

“Brazilian researchers connect gene mutation to blood conditions” This reference links to a non-governmental website 
(June 21) English People’s Daily Online reports, “Researchers from Brazilian University of Campinas (Unicamps) said in a report published on Tuesday that they had discovered for the first time a new mutation on the GATA-1 gene that codifies the GATA-1 and GATA-1S proteins.”

“German scientists uncover gene for learning disability” This reference links to a non-governmental website 
(June 21) English People’s Daily Online reports, “German researchers have successfully located the gene responsible for the learning disability dyslexia, which could open the way for treatment of the disease, local reports said Tuesday.”

“Testing embryos for genetic defects” This reference links to a non-governmental website 
(June 21) Cape Times reports, “Over the past couple of decades genetic testing has gone through a period of dramatic development from an era when it was a truly experimental technique to one where it is almost routine for couples at risk of passing on inherited defects in their DNA.”

“Two year wait for breast cancer test results drives women to consider radical surgery” This reference links to a non-governmental website 
(June 20) News-Medical.Net reports, “Women in the UK being put under added stress because they are experiencing delays of two years or more for test results to see if they carry a gene associated with an increased likelihood of breast cancer.”

“Study finds new genetic variant linked with breast cancer” This reference links to a non-governmental website 
(June 20) English.eastday.com reports, “A variant of a gene may have a role in triggering breast cancer in some women, according to a new study published on Monday.”

“Cells Use Mix-and-match Approach To Tailor Regulation Of Genes” This reference links to a non-governmental website 
(June 20) Medical News Today reports, “Scientists eager to help develop a new generation of pharmaceuticals are studying cellular proteins called transcription factors, which bind to upstream sequences of genes to turn the expression of those genes on or off.”

“Common Genetic Prostate Cancer Variant Is Identified” This reference links to a non-governmental website 
(June 20) Medical News Today reports, “Prostate cancer (CaP) is a presumed result of both genetic and environmental events. It is known that a positive family history and African-American ancestry will increase the risk of developing CaP 2-4 fold.”

“Study looks for genetic predictors of hypertension” This reference links to a non-governmental website (last accessed 2/2008)
(June 19) Medical College of Georgia reports, “Whether genes responsible for a rare disorder that dramatically elevates blood pressure holds clues for identifying many people at risk for hypertension is the focus of a new study.”

“After genetic testing, 11 cousins give up stomachs to avoid cancer” This reference links to a non-governmental website (last accessed 2/2008)
(June 18) USAToday reports, “Mike Slabaugh doesn't have a stomach. Neither do his 10 cousins.”

“Rare disease's gene may illuminate major disorders” This reference links to a non-governmental website 
(June 18) EurekAlert! reports, “Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.”

“Study: Genes, brain chemistry may determine anorexia” This reference links to a non-governmental website 
(June 16) Physorg.com reports, “Luanne Sanders remembers her first diet, when she was 14 years old, because the results were so dramatic.”

“The biology of mental illness”  
(June 16) Baltimoresun.com reports, “One percent of all Americans - some 2.4 million people - have schizophrenia. An estimated 5.7 million have bipolar disorder. And 2.2 million adults have obsessive-compulsive disorder.”

“Activation Of MicroRNA Inhibits Cancer Gene In Human Cancer Cells” This reference links to a non-governmental website 
(June 15) Medical News Today reports, “Scientists report that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome.”

“When it comes to gene transcription, random pauses aren’t quite so random, study finds” This reference links to a non-governmental website 
(June 15) EurekAlert! reports, “Of the thousands of proteins produced in our cells, few are as important as the enzyme RNA polymerase (RNAP), which has the unique ability to faithfully copy genetic information from DNA.”

“Genes and behavior: Liberation or destiny?” This reference links to a non-governmental website 
(June 15) International Herald Tribune reports, “Jason Dallas used to think of his daredevil streak - a love of back-country skiing, mountain bikes, and fast vehicles - as "a personality thing."

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Genomics in Scientific Literature
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Consent for genetic research in a general population: An update on the National Health and Nutrition Examination Survey experience
McQuillan GM, et al.
Genet Med 2006 Jun;8(6):354-60

Genetics of Kidneys in Diabetes (GoKinD) Study: A Genetics Collection Available for Identifying Genetic Susceptibility Factors for Diabetic Nephropathy in Type 1 Diabetes
Mueller PW, et al.
J Am Soc Nephrol 2006 Jun

Genomics and epigenomics of hypertension
Fornage M & Doris PA
Curr Opin Mol Ther 2006 Jun;8(3):206-14

Understanding of genetics among older adults
Frazier L, et al.
J Nurs Scholarsh 2006;38(2):126-32

Ethics, policy, and educational issues in genetic testing
Williams JK, et al.
J Nurs Scholarsh 2006;38(2):119-25

Pharmacogenetics in inflammatory bowel disease
Pierik M, et al.
World J Gastroenterol 2006 Jun;12(23):3657-67

Genetics of inflammatory bowel disease: The role of the HLA complex
Ahmad T, et al.
World J Gastroenterol 2006 Jun;12(23):3628-35

Case-control genetic association studies in gastrointestinal disease: review and recommendations
Saito YA, et al.
Am J Gastroenterol 2006 Jun;101(6):1379-89

The AmpliChiptrade mark CYP450 Genotyping Test : Integrating a New Clinical Tool
de Leon J, et al.
Mol Diagn Ther 2006;10(3):135-51

Integration of internet-based genetic databases into the medical school pre-clinical and clinical curriculum
Waggoner DJ & Martin CL
Genet Med 2006 Jun;8(6):379-82

Genetic testing for susceptibility to breast and ovarian cancer: Evaluating the impact of a direct-to-consumer marketing campaign on physicians' knowledge and practices
Myers MF, et al.
Genet Med 2006 Jun;8(6):361-70

Consent for genetic research in a general population: An update on the National Health and Nutrition Examination Survey experience
McQuillan GM, et al.
Genet Med 2006 Jun;8(6):354-60

Non-major-histocompatibility-complex genetics of ankylosing spondylitis
Brown MA Mb Bs Md Fracp
Best Pract Res Clin Rheumatol 2006 Jun;20(3):611-21

Major histocompatibility genes and ankylosing spondylitis
Reveille JD
Best Pract Res Clin Rheumatol 2006 Jun;20(3):601-9

Host genetics and viral infections: immunology taught by viruses, virology taught by the immune system
Nolan D, et al.
Curr Opin Immunol 2006 Jun

Use of standardized patients in, undergraduate medical genetics education
McGovern MM, et al.
Teach Learn Med 2006 Summer;18(3):203-7

Family history of diabetes is a major determinant of endothelial function
Goldfine AB, et al.
J Am Coll Cardiol 2006 Jun;47(12):2456-61

Do patients with inflammatory bowel disease want genetic testing?
Konda V, et al.
Inflamm Bowel Dis 2006 Jun;12(6):497-502

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 21, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Mountain States Genetics Center Regional Collaborative Center Annual Meeting This reference links to a non-governmental website
July 13-15, 2006 ~ Greenwood Village, Colorado

 

Secretary’s Advisory Committee on Genetics, Health, and Society’s Tenth Meeting
June 26-27, 2006 ~ Bethesda, MD

   
 

The Second International Human ES Cell WorkshopThis reference links to a non-governmental website (last accessed 2/2008)
August 3-6, 2006 ~ Bar Harbor, Maine

   
 

The Genome Access Course This reference links to a non-governmental website (last accessed 2/2008)
August 29-30, 2006 ~ Cold Spring Harbor

   
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Let's Go Surfing
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FORCE: Facing our Risk of Cancer Empowered This reference links to a non-governmental website
The free Webcast from the first annual symposium on hereditary breast and ovarian cancer is now available.

CDC’s Prevention Research Centers (PRC) Program
The PRC Program has just released a new version of its website including enhanced access to information about tested interventions, training, research projects, and information about individual Centers and the overall program.

Gene and Self-Image Video Clip
The discovery of genes that seem to influence everything from obesity to addiction is changing the way people feel about themselves, Amy Harmon reports from the New York Times.

Tour of Basics This reference links to a non-governmental website
The University of Utah created a tour to explain the basics of DNA, genes, chromosomes, proteins, heredity and trait.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
 
Page last reviewed: June 221, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics