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 Thursday, June 8, 2006     Volume 16   Number 23  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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HuGE Published Literature Database
The HuGE Published Literature Database (HuGE Pub Lit) is a searchable, online knowledge base of published, population-based epidemiologic studies of human genes. The database contains links to PubMed articles and can be searched by gene, disease, interacting factor, type of study design or analysis, or any combination of terms in these categories. Read the scientific article in the American Journal of Epidemiology that provides an overview of the database.

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CDC Announcements
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CDC's 2006 National Health Promotion Conference
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic disease, and genomics. Registration is now open.

CDC sponsored material

New HuGE Case Studies

CDC sponsored material HuGE What's New
June 2006
CDC sponsored material

New HuGE Review
Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism: A HuGE Review and Meta-Analysis you will need a free Acrobat reader to view this file(169KB)
Philip S. Wells et al.  American Journal of Epidemiology (June 2006)

CDC sponsored material New HuGE Review
XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer you will need a free Acrobat reader to view this file (3.0MB / Web tables included)
Maurizio Manuguerra et al. Genetics in Medicine (April 2006)
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Large-scale genomics project will hunt genes behind common childhood diseases” This reference links to a non-governmental website 
(June 7) EurekAlert! reports, “The Children's Hospital of Philadelphia is launching an ambitious program to identify the genes responsible for common childhood diseases.”

“First Whole-genome Scan For Links To OCD Reveals Evidence For Genetic Susceptibility” This reference links to a non-governmental website 
(June 8) Medical News Today reports, “A federally funded team of researchers including several from Johns Hopkins have identified six regions of the human genome that might play a role in susceptibility to obsessive compulsive disorder, or OCD.”

“Gene Technology Spots Burkitt's Lymphoma” This reference links to a non-governmental website (last accessed 2/2008)
(June 7) CBS News reports, “A new gene-based technology is helping doctors distinguish between people who have a rare blood cancer called Burkitt's lymphoma and those who have a more common form of lymphoma, researchers report.”

“Ticking biological clock no longer just for women” This reference links to a non-governmental website (last accessed 2/2008)
(June 6) The Washington Times reports, “Gentleman, the biological clock may toll for thee, as well. New findings released yesterday by separate American and French research teams indicate that a man's age can compromise his fertility -- a concern that has long plagued women.”

“Cancer-reducing Benefits Of Preventive Surgery May Be Specific To Gene Mutation” This reference links to a non-governmental website
(June 6) Medical News Today reports, “A new multicenter study is the first to suggest that the prophylactic removal of the ovaries and fallopian tubes may provide a different benefit for women who carry a genetic mutation in the BRCA2 gene than for those who have a BRCA1 genetic mutation.”

“Scientists find gene sequence data of Chikungunya virus”
(June 5) Zeenews.com reports, “Scientists have for the first time come out with genetic sequence data of the 'chikungunya viruses', shedding light on the origin of their outbreak and huge populations of the Indian Ocean countries, most recently in India.”

“Genes variations raise risk of heart disease after treatment for childhood cancer” This reference links to a non-governmental website
(June 5) News-Medical.Net reports, “Gene variations may raise the risk that survivors of childhood cancer will suffer congestive heart failure as a complication of drugs they received during cancer treatment.”

“Heel prick test can cause unnecessary parental stress” This reference links to a non-governmental website
(June 5) News-Medical.Net reports, “Virtually all babies in the U.S. have their heels pricked soon after birth to get a blood sample for genetic testing.”

“New test offers speedy reading of genetic makeup” This reference links to a non-governmental website
(June 2) Guardian Unlimited reports, “American scientists have ushered in an era of personalised genetics by reading an individual's entire genetic makeup in record time.”

“Progress In Gene Therapy For Immune Deficiency Diseases, Presented At The ASGT 9th Annual Meeting” This reference links to a non-governmental website
(June 2) Medical News Today reports, “A study showing that gene therapy may provide some benefit to certain older X-linked severe combined immunodeficiency (XSCID) patients, who remain significantly immunodeficient after bone marrow transplantation, will be presented on Saturday, June 3 at the 9th Annual Meeting of the American Society of Gene Therapy (ASGT) in Baltimore.”

“Pituitary adenoma predisposition caused by germline mutations in the AIP gene” This reference links to a non-governmental website
(June 1) News-Medical.Net reports, “A recent Finnish study identifies a low-penetrance gene defect which predisposes carriers to intracranial tumors called pituitary adenomas. In particular individuals carrying the gene defect are susceptible to such tumors which secrete growth hormone.”

“Genes promising in kids' immune disorder” This reference links to a non-governmental website
(June 1) United Press International reports, “Government researchers will this week present data showing a new gene therapy may fight an immunity disorder in kids.”

“New Clinic Focuses on Genetic Cause of Sudden Cardiac Death” This reference links to a non-governmental website
(June 1) Newswise reports, “Some families seem cursed with especially bad heart health, losing members of several generations in sudden, tragic deaths at young ages.”

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Genomics in Scientific Literature
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American Academy of Pediatrics Newborn Screening Task Force recommendations: how far have we come?
Lloyd-Puryear MA, et al.
Pediatrics 2006 May;117(5 Pt 2):S194-211

PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
Allen-Brady K, et al.
BMC Bioinformatics 2006;7:209

Familial Risk of Ischemic and Hemorrhagic Stroke. A Large-Scale Study of the Swedish Population
Sundquist K, et al.
Stroke 2006 Jun

Genetic Predictors of Adverse Radiotherapy Effects: The Gene-PARE project
Ho AY, et al.
Int J Radiat Oncol Biol Phys 2006 Jul;65(3):646-55

Screening younger women with a family history of breast cancer - does early detection improve outcome?
Maurice A, et al.
Eur J Cancer 2006 Jun

Are genetic tests exceptional? Lessons from a qualitative study on thrombophilia
Saukko PM, et al.
Soc Sci Med 2006 Jun

EUDRAGENE: European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions
Molokhia M & McKeigue P
Pharmacogenomics 2006 Jun;7(4):633-8

Resampling-based multiple hypothesis testing procedures for genetic case-control association studies
Chen BE, et al.
Genet Epidemiol 2006 Jun

Simple estimates of haplotype relative risks in case-control data
French B, et al.
Genet Epidemiol 2006 Jun

Pharmacogenomics of acute lymphoblastic leukemia
Kager L & Evans WE
Curr Opin Hematol 2006 Jul;13(4):260-5

Differential Impact of Family History on Age-Associated Increase in the Prevalence of Hypertension and Diabetes in Male Japanese Workers
Shirakawa T, et al.
Hypertens Res 2006;29(2):81-7

Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes
Malecki MJ, et al.
Mol Cell Biol 2006 Jun;26(12):4642-51

A vision of the future of newborn screening
Alexander D & van Dyck PC
Pediatrics 2006 May;117(5 Pt 2):S350-4

Recommendations for effective newborn screening communication: results of focus groups with parents, providers, and experts
Davis TC, et al.
Pediatrics 2006 May;117(5 Pt 2):S326-40

Status of newborn screening programs in the United States
Therrell BL, et al.
Pediatrics 2006 May;117(5 Pt 2):S212-52

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 7, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

Gene Therapy for Inherited Deficiencies: Advances and Safety Issues This reference links to a non-governmental website (last accessed 2/2008)
September 18-19, 2006 ~ Bethesda, MD

New this week Williams Syndrome: Genetics, Neuroimaging, Cognition and Clinical Issues This reference links to a non-governmental website you will need a free Acrobat reader to view this file
July 23-24, 2006 ~ Richmond, VA
   
New this week

The Genomic Revolution and the Origin of Humanity This reference links to a non-governmental website
August 4-5, 2006 ~ McMaster University, Ontario, Canada

   
New this week From Genetics to Community: What is Obesity? This reference links to a non-governmental website
September 9-10, 2006 ~ Auckland, New Zealand
   
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Let's Go Surfing
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June 2006 eNewsletter from the Genetics & Public Policy Center This reference links to a non-governmental website

Genetics Home Reference-Your Guide to Understanding Genetic Conditions
Genetics Home Reference is the National Library of Medicine's website for consumer information about genetic conditions and the genes or chromosomes responsible for those conditions.

Duchenne/Becker Muscular Dystrophy (DBMD)
Center for Disease Controls information page on DBMD

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: June 81, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics