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 Thursday, February 2, 2006     Volume 16   Number 5  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Public health professional

U.S. Surgeon General's Family History Resource Packet for Health Professionals
This free, online resource packet was developed to help health professionals educate the public about the importance of family health history.

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CDC Announcements
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CDC’s National Health Promotion Conference - Save the Date
September 12-14, 2006 ~ Atlanta, GA
The 2006 National Health Promotion Conference is the first joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) and its constituent groups: the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), the National Center on Birth Defects and Developmental Disabilities (NCBDDD), and the Office of Genomics and Disease Prevention (OGDP).
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Researchers Link Mutant Gene to Crib Deaths in Blacks”
(February 2) Los Angeles Times reports, “About 5% of African American SIDS cases are blamed on a defect also found in adults with arrhythmias. The finding could lead to a treatment.”

“Mount Sinai School of Medicine launches a phase II clinical trial for new gene transfer drug study” This reference links to a non-governmental website
(February 2) EurekAlert! reports, “As many as 8-10 million Americans have Peripheral Artery Disease (PAD), by age 70, roughly 20 percent of the population has it, and people with PAD face a six-to-seven times higher risk of heart attack or stroke.”

“Study Finds 60 New Genes Controlled By DNA Snippet” This reference links to a non-governmental website
(February 2) Medical News Today reports, “Researchers worldwide are seeking to define ancient sections of our genetic code that may soon be as important to medical science as genes.”

“Scientists more likely to have autistic children” This reference links to a non-governmental website
(January 31) News Medical.net reports, “According to an expert in the UK, highly analytical couples such as scientists, engineers, physicists and mathematicians, are more likely to produce children with autism.”

“Scientists find genetic pathway that could lead to drugs for kidney disease” This reference links to a non-governmental website
(January 31) EurekAlert! reports, “Scientists at the University of California, Santa Barbara have reported a discovery at the cellular level that suggests possibilities for drug therapy for kidney disease.”

“Discovery of new gene for rare nerve disease may help doctors understand more common illnesses” This reference links to a non-governmental website
(January 31) EurekAlert! reports, “A multi-national research team that includes a Saint Louis University neurologist has discovered a gene mutation that causes a rare form of Charcot-Marie-Tooth disease, an inherited progressive nerve disorder.”

“8 million children born every year with serious birth defects” This reference links to a non-governmental website
(January 31) News Medical.net reports, “According to a new report, every year an estimated 8 million children are born with a serious birth defect of genetic or partially genetic origin.”

“Gene tests from shops and internet 'waste of money'” This reference links to a non-governmental website
(January 30) Guardian Unlimited reports, “A range of genetic tests sold in health shops and over the internet have been been branded a waste of money by leading scientists, because there is no evidence they work.”

“Genetic link found for gooey earwax” This reference links to a non-governmental website
(January 30) ABC News Online reports, “Geneticists say they know why people from some parts of the world have wet, gooey earwax and others have the dry, flaky stuff.”

“World's Largest Genetic Resource Chooses The Automation Partnership To Supply Its Automated - 80?C Biological Sample Archive” This reference links to a non-governmental website
(January 29) Medical News Today reports, “The Automation Partnership (TAP) a world leading manufacturer of innovative industrial automation for life science applications, is delighted to announce that it has been asked to design and implement the -80?C automated sample management system for the prestigious UK Biobank project.”

“Gene variant may create a taste for alcoholism” This reference links to a non-governmental website
(January 27) Washington University in St, Louis reports, “Researchers at the Washington University School of Medicine recently published their findings of an association between increased risk for alcoholism and certain taste buds.”

“First large-scale bird flu genome study” This reference links to a non-governmental website
(January 26) News Medical.net reports, “Investigators at St. Jude Children's Research Hospital have completed the first large-scale study of bird flu virus genomes, thereby doubling the amount of genetic information available on the genes and proteins of these viruses.”

“Researchers map of genetic variations implicated in disease” This reference links to a non-governmental website
(January 26) EurekAlert! reports, “Sequence differences in less than 0.2% of the 3-billion-base human genome play a vital role in a bewildering variety of human disease.”

“Genes, not smoking habits, may be behind lung cancers” This reference links to a non-governmental website
(January 26) The Globe and mail.com reports, “For years, scientists have argued about whether genes or smoking habits are responsible for the disparities in lung cancer rates among smokers of different ethnic backgrounds.”

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Genomics in Scientific Literature
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GPNN: Power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease
Motsinger AA, et al.
BMC Bioinformatics 2006 Jan;7(1):39

Molecular genetics of bipolar disorder
Hayden EP & Nurnberger JI Jr
Genes Brain Behav 2006 Feb;5(1):85-95

IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion
Chantzi FM, et al.
Allergy 2006 Mar;61(3):332-6

Identification of probable genotyping errors by consideration of haplotypes
Becker T, et al.
Eur J Hum Genet 2006 Jan

Intentions to Participate in Genetics Research among African American Smokers
Halbert CH, et al.
Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):150-3

How Well Do HapMap Haplotypes Identify Common Haplotypes of Genes? A Comparison with Haplotypes of 334 Genes Resequenced in the Environmental Genome Project
Taylor JA, et al.
Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):133-7

Evaluating Bias due to Population Stratification in Epidemiologic Studies of Gene-Gene or Gene-Environment Interactions
Wang Y, et al.
Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):124-32

Complementary Medicine Use before and 1 Year Following Genetic Testing for BRCA1/2 Mutations
Digianni LM, et al.
Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):70-5

Does "clock" matter in prostate cancer?
Zhu Y, et al.
Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):3-5

The genetics of HNPCC: Application to diagnosis and screening
Abdel-Rahman WM, et al.
Crit Rev Oncol Hematol 2006 Jan

Evaluation of two different models to predict BRCA1 and BRCA2 mutations in a cohort of Danish hereditary breast and/or ovarian cancer families
Gerdes AM, et al.
Clin Genet 2006 Feb;69(2):171-8

Educational outcomes of a workplace screening program for genetic susceptibility to hemochromatosis
Nisselle AE, et al.
Clin Genet 2006 Feb;69(2):163-70

Pharmacogenomics in inflammatory bowel disease
Egan LJ, et al.
Clin Gastroenterol Hepatol 2006 Jan;4(1):21-8

Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies
Sharma P, et al.
Lipids Health Dis 2006 Jan;5(1):1

Comparative pharmacogenomics of antiretroviral and cytotoxic treatments
Stebbing J & Bower M
Lancet Oncol 2006 Jan;7(1):61-8

Genetic testing in competitive insurance markets with repulsion from chance: A welfare analysis
Hoel M, et al.
J Health Econ 2006 Jan

Periodontal status among relatives of aggressive periodontitis patients and reliability of family history report
Llorente MA & Griffiths GS
J Clin Periodontol 2006 Feb;33(2):121-5

HLA class II disease associations in southern Africa
Lombard Z, et al.
Tissue Antigens 2006 Feb;67(2):97-110

A Likelihood Ratio Approach to Family-based Association Studies with Covariates
Baksh MF, et al.
Ann Hum Genet 2006 Jan;70(Pt 1):131-9

Case-control association tests correcting for population stratification
Kohler K & Bickeboller H
Ann Hum Genet 2006 Jan;70(Pt 1):98-115

Aspects of the Design and Analysis of High-Dimensional SNP Studies for Disease Risk Estimation
Prentice RL & Qi L
Biostatistics 2006 Jan

Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes
Salmela E, et al.
J Med Genet 2006 Jan

Gene by environment interactions and the development of asthma and allergy
Kabesch M
Toxicol Lett 2006 Jan

Genetics of rheumatoid arthritis
Turesson C & Matteson EL
Mayo Clin Proc 2006 Jan;81(1):94-101

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 1, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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Gene Expression & Singaling in the Immune System  This reference links to a non-governmental website (last accessed 01/2008)
April 26-30, 2006 ~ Cold Spring Harbor, NY

DNA Damage, Mutation & Cancer Gordon Research Conference This reference links to a non-governmental website
March 5-10, 2006 ~ Ventura, California
   
New this week 10th International Conference on Alzheimer's Disease and Related Disorders This reference links to a non-governmental website
August 15-20, 2006 ~ Madrid, Spain
   
New this week 5th European Congress of Biogerontology This reference links to a non-governmental website
September 16-20, 2006 ~ Istanbul, Turkey
   
New this week Neurodegenerative Diseases: Biology & Therapeutics This reference links to a non-governmental website (last accessed 01/2008)
November 30 - December 3, 2006 ~ Cold Spring Harbor, NY
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Let's Go Surfing
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Genetics and Public Policy Fellowship This reference links to a non-governmental website
This fellowship program is designed for genetics professionals with an advanced degree who are early in their careers and interested in the development and implementation of national genetics health and research policies. Application deadline is 4/28/06.

Family History and Your Health
February Newsletter from the Michigan Department of Community Health

Straight talk on molecular reports This reference links to a non-governmental website
The College of American Pathologists Monthly Newsletter (CAP Today)

March of Dimes Global Report on Birth Defects This reference links to a non-governmental website (last accessed 01/2008)
“This report is the first to provide global estimates of birth prevalence for serious birth defects of genetic or partially genetic origin.”

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: February 2, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics