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 Thursday, Dec. 21, 2006     Volume 17   Number 24  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
Happy Holidays!
The NOPHG staff wishes you a wonderful holiday season!
Spotlight
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2006 Program Review Book

CDC’s National Office of Public Health Genomics (NOPHG) is pleased to announce the 2006 Program Review Book is now available online.

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CDC Announcements
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On the synthesis and interpretation of consistent but weak gene–disease associations in the era of genome-wide association studies you sill need a free Acrobat reader to view this file(82 KB)
Muin J. Khoury, Julian Little, Marta Gwinn and John PA Ioannidis
Int. J. Epidemiol - December 2006

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Cancer Gene Mutations Not Uncommon In General Population” This reference links to a non-governmental website
(Dec 16) Medical News Today reports, “Cancer gene mutations are found in about one percent of the total general population, occurring more frequently than previously thought, and may be associated with various types of cancers, according to researchers at Yale School of Medicine.”

“Gene Chip Discovery May Lead To Individualized Treatment For Five Hereditary Liver Diseases”  This reference links to a non-governmental website
(Dec 21) Medical News Today reports, “Researchers at Cincinnati Children's Hospital Medical Center have developed the first gene chip to use in the early diagnosis of at least five hereditary liver diseases, to detect genetic causes of jaundice in children and adults, and potentially to lead to personalized treatment options.”

“Human mating habits may increase obesity gene pool”  This reference links to a non-governmental website (last accessed 2/2008)
(Dec 21) Reuters Health via Healthlibrary.com reports, “People's tendency to choose mates with body sizes matching their own could be one factor driving the current obesity epidemic, according to a new study.”

“Obesity Alters Digestive-Tract Bacteria” This reference links to a non-governmental website (last accessed 2/2008)
(Dec. 20) HealthDay News reports, “Finding could lead to new weight-loss treatments, study suggests.”

“Gene-bender Proteins May Sway To DNA” This reference links to a non-governmental website
(Dec 19) Science Daily reports, “Among the many genes packed into each cell of our body, those that get turned on, or expressed, are the ones that make us who we are.”

“Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA” This reference links to a non-governmental website
(Dec 18) News-Medical.Net reports, “Researchers from the Swiss Nanoscience Institute in Basel have developed a rapid method to detect the activity of a gene involved in controlling tumor growth.”

“Surprising Interaction Between Genes, Gender, And Hypertension” This reference links to a non-governmental website
(Dec 18) Medical News Today reports, “In surprising results, a study of more than 1,200 patients with extremely low or high blood pressure by researchers at the University of California, San Diego (UCSD) School of Medicine showed that the influence of genes on blood pressure may vary based on gender.”

“Genes That Allow Brain Cancer-Causing Stem Cells To Resist Treatment Identified” This reference links to a non-governmental website
(Dec 18) Medical News Today reports, “While great interest has followed the discovery of neural stem cells and their potential for someday treating diseases and injuries of the brain and spinal cord, recent research identified "cancer stem cells," a small population of cells that appear to be the source of cells comprising a malignant brain tumor.”

“Two Central Mysteries In Genome Inheritance Solved” This reference links to a non-governmental website
(Dec 17) Science Daily reports, “The dance of the chromosomes during cell division, first described in the late 1800s and familiar to all high-school students from movies shown in biology classes, has long fascinated biologists.”

“Genetics Predicts Toxicity Following Blood And Marrow Transplantation” This reference links to a non-governmental website
(Dec 17) Medical News Today reports, “The outlook for cancer patients treated with blood and marrow transplantation (BMT) for fatal blood cancers is much brighter today based on research conducted at Roswell Park Cancer Institute (RPCI).”

“One Gene 90 Percent Responsible For Making Common Parasite Dangerous” This reference links to a non-governmental website
(Dec 16) Science Daily reports, “More than a decade of searching for factors that make the common parasite Toxoplasma gondii dangerous to humans has pinned 90 percent of the blame on just one of the parasite's approximately 6,000 genes.”

“Study explains how NSAIDs halt cancer growth” This reference links to a non-governmental website
(Dec 15) EurekAlert! reports, “Scientists have discovered that induction of a gene known as MDA-7/IL-24 is the molecular mechanism that enables nonsteroidal anti-inflammatory drugs (NSAIDs) to halt the growth of cancer cells, a finding that could eventually lead to the development of targeted cancer treatments.”

“Pair of microRNA molecules controls major oncogene in most common leukemia” This reference links to a non-governmental website
(Dec 15) EurekAlert! reports, “Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world.”

“Screening For Colon Cancer By Analyzing Our Non-DNA Epigenetic Inheritance” This reference links to a non-governmental website
(Dec 14) Medical News Today reports, “Most people have heard that human inheritance is spelled out in our DNA and activated through our genes. Yet few know anything about epigenetics, a variety of methods that our cells have evolved to transmit heritable changes without changing DNA.”

“Study: Genetics-based medicine problematic” This reference links to a non-governmental website
(Dec 14) Earthtimes.org reports, “A U.S. researcher says obstacles facing development of genetics-based personalized medicine include the problematic use of race and ethnicity.”

“Celera Identifies Two Genetic Variations Predisposing Individuals to Increased Risk for
Psoriasis”
This reference links to a non-governmental website
(Dec 14) Google reports, “Celera, an Applera Corporation business, today announced the publication of its findings that variants in two genes (IL12B and IL23R) involved in regulating the behavior of cells of the immune system independently contribute to psoriasis risk. Individuals who carry two copies of the risk alleles for both these genes, which occur in approximately 25 percent of Caucasians, were found to have a three-fold increased risk for psoriasis relative to individuals with certain other genotypes of these genes.”

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Genomics in Scientific Literature
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Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
Bourgain C, et al.
Eur J Hum Genet 2006 Dec

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies
Pearson JV, et al.
Am J Hum Genet 2007 Jan;80(1):126-39

Familial colorectal cancer referral to regional genetics department-a single centre experience
Mak T, et al.
Fam Cancer 2006 Dec

Variants in mannose-binding lectin and tumor necrosis factor {alpha} affect survival in cystic fibrosis Buranawuti K, et al.
J Med Genet 2006 Dec

The use of the life course paradigm and life course charts to explore referral for family history of breast cancer
Benjamin C, et al.
Int J Nurs Stud 2006 Dec

Optimization of Two-Stage Genetic Designs Where Data Are Combined Using an Accurate and Efficient Approximation for Pearson's Statistic
Bukszar J & van den Oord EJ
Biometrics 2006 Dec;62(4):1132-7

Statistical analysis for haplotype-based matched case-control studies
Zhang H, et al.
Biometrics 2006 Dec;62(4):1124-31

Susceptibility of biallelic haplotype and genotype frequencies to genotyping error
Moskvina V & Schmidt KM
Biometrics 2006 Dec;62(4):1116-23

Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension
Farahani P, et al.
J Clin Epidemiol 2007 Jan;60(1):1.e1-1.e11

Confidentiality versus duty to inform-An empirical study on attitudes towards the handling of genetic information
Wolff K, et al.
Am J Med Genet A 2006 Dec

Provision of breast cancer risk information to women at the lower end of the familial risk spectrum
Ozakinci G, et al.
Community Genet 2007;10(1):41-4

Barriers to access: results from focus groups to identify genetic service needs in the community
Beene-Harris RY, et al.
Community Genet 2007;10(1):10-8

Informed consent and subject motivation to participate in a large, population-based genomics study: the marshfield clinic personalized medicine research project
McCarty CA, et al.
Community Genet 2007;10(1):2-9

Pharmacogenetics of asthma
Hall IP
Chest 2006 Dec;130(6):1873-8

Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes
Weyrich P, et al.
J Mol Med 2006 Dec

Genetics of human obesity
Mutch DM & Clement K
Best Pract Res Clin Endocrinol Metab 2006 Dec;20(4):647-6

Family History
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“A painkilling gene discovered”
(Dec 18) philly.com reports, “Researchers have linked a single genetic mutation to a complete loss of pain sensation among a half-dozen Pakistani children, a discovery heralded by other experts as a "beautiful" bit of detective work that could eventually lead to potent whole-body pain relievers.”

“Scientists identify gene mutation in autism” This reference links to a non-governmental website (last accessed 2/2008)
(Dec 18) digitaljournal reports, “French scientists have identified genetic mutations in a small number of children with autism which could provide insight into the biological basis of the disorder.”

Family history of cancer and the risk of renal cell cancer
Negri E, et al.
Cancer Epidemiol Biomarkers Prev 2006 Dec;15(12):2441-4

Attention Problems among Children with a Positive Family History of Alcohol Abuse or Dependence and Controls. Prevalence and Course for the Period from Preteen to Early Teen Years
Barnow S, et al.
Eur Addict Res 2007;13(1):1-5

CDC authored material  Evaluation of family history as a risk factor and screening tool for detecting undiagnosed diabetes in a nationally representative survey population
Hariri S, et al.
Genet Med 2006 Dec;8(12):752-9

Genetic services for men: The preferences of men with a family history of prostate cancer
Gaff CL, et al.
Genet Med 2006 Dec;8(12):771-8

First-degree relative history of alcoholism in eating disorder inpatients: Relationship to eating and substance use psychopathology
Redgrave GW, et al.
Eat Behav 2007 Jan;8(1):15-22

Genetic Testing
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“Can Your Genetic Make-up Predict What You Should Eat?” This reference links to a non-governmental website
(Dec 19) Medical News Today reports, “A new study conducted by academics at Exeter University will for the first time challenge claims made by companies and governments that we should alter our diet according to our genetic make-up.”

“Genomic Tests Improve Prediction Of Breast Cancer Response To Chemotherapy, Hormonal
Therapy”
This reference links to a non-governmental website
(Dec 18) Science Daily reports, “Researchers at The University of Texas M. D. Anderson Cancer Center have developed two genomic tests to better predict how breast cancer patients will respond to chemotherapy or hormonal therapy.”

“Researchers Find Gene Linked to Inflammatory Bowel Diseases” This reference links to a non-governmental website
(Dec 18) The JHU Gazette reports, “An international team of researchers has identified another gene mutation linked to the inflammatory bowel diseases Crohn's disease and ulcerative colitis.”

“Genesearch Breast Lymph Node assay detects breast cancer metastases with greater
sensitivity”
This reference links to a non-governmental website
(Dec 16) EurekAlert! reports, “Results from a prospective clinical study show that the GeneSearch™ Breast Lymph Node (BLN) Assay, a gene-based diagnostic test has greater sensitivity than traditional intra-operative methods of detecting the spread of breast cancer to the lymph nodes.”

Implications of genetic testing for sudden cardiac death syndrome
Royse SD
Br J Nurs 2006 Nov;15(20):1104-7

Uptake of BRCA1 rearrangement panel testing: In individuals previously tested for BRCA1/2 mutations
Shannon KM, et al.
Genet Med 2006 Dec;8(12):740-5

Recall of disclosed Apolipoprotein E genotype and lifetime risk estimate for Alzheimer's disease: The REVEAL Study
Eckert SL, et al.
Genet Med 2006 Dec;8(12):746-51

Familial testicular cancer: Interest in genetic testing among high-risk family members
Peters JA, et al.
Genet Med 2006 Dec;8(12):760-70

A focus group study of consumer attitudes toward genetic testing and newborn screening for deafness
Burton SK, et al.
Genet Med 2006 Dec;8(12):779-83

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending December 20, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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Oncogenomics 2007: Dissecting Cancer Through Genome Research This reference links to a non-governmental website
January 31 - February 3, 2007 ~ Phoenix, AZ
New This Week

Genome Instability and Repair This reference links to a non-governmental website
January 17-22, 2007 ~ Breckenridge, CO

   
New This Week ISOPOL XVI: 16th International Symposium on Problems of Listeriosis This reference links to a non-governmental website (last accessed 2/2008)
March 20-23, 2007 ~ Savannah, GA
   
New This Week Epigenetics: Regulation of Chromatin Structure in Development and Disease This reference links to a non-governmental website
April 11-16, 2007 ~ Breckenridge, CO
   
New This Week Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection & Therapy This reference links to a non-governmental website
October 14-19, 2007 ~ Beijing, China
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Let's Go Surfing
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Minnesota Gene Pool Weblog This reference links to a non-governmental website
On-line weblog for public health practitioners and healthcare professionals who are interested in the role of genetics and genomics in health promotion and disease prevention.

Ask the GeneticistSM This reference links to a non-governmental website
The mission of Ask the GeneticistSM is to answer questions about genetic concepts, and the etiology, treatment, research, testing, and predisposition to genetic disorders.

Obesity in America: Is Your State Overweight? This reference links to a non-governmental website
by Kathleen Donnelly for MSN Health & Fitness


 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: December 21, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics