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 Thursday, Dec. 7, 2006     Volume 17   Number 22  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic discoveries on health care, disease prevention and population health.
Spotlight
view the current Update
2006 Program Review Book

CDC’s National Office of Public Health Genomics (NOPHG) is pleased to announce the 2006 Program Review Book is now available online.

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CDC Announcements
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HuGE What's New
December 2006
   
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New HuGE Review
Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer you will need a free Acrobat reader to view this file(128KB)
Sara H. Olson, et al.
Am J Epidemiol. 2006 Nov 16
   
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Spotlight newsletter launched by University of Washington Center for Genomics and Public Health   This reference links to a non-governmental website you will need a free Acrobat reader to view this file (336 KB)
In November 2006, the University of Washington Center for Genomics and Public Health (UWA CGPH) This reference links to a non-governmental website launched the Spotlight newsletter to educate and update public health practitioners, physicians, and the public on topics in genomics. The first issue of this newsletter highlights the importance of family history in improving public health, and initiatives by the U.S. Surgeon General and CDC’s National Office of Public Health Genomics (NOPHG). The newsletter was disseminated to the 25 branches of the Seattle library system, and medical clinics and their satellite locations throughout Washington.

UWA CGPH and the University of Michigan Center for Public Health and Community Genomics are supported through a cooperative agreement with NOPHG. These Centers provide leadership and technical assistance in genomics, and collaborate on various projects with NOPHG projects (e.g., Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Project and the Family History Public Health Initiative), and state and local health departments.

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“NIDA Researchers Complete Unprecedented Scan of Human Genome That May Help Unlock the Genetic Contribution to Tobacco Addiction” This reference links to a non-governmental website
(Dec 4) NIH News reports, “Results of a new genetic study bring scientists one step closer to understanding why some smokers become addicted to nicotine, the primary reinforcing component of tobacco.”

“Scientists make gene detection breakthrough”
(Dec 7) swissinfo reports, “Researchers from the Swiss Nanoscience Institute in Basel have developed a new method to detect genes relevant to diseases and their treatment.”

“New 'GreeneChip' identifies multiple pathogens rapidly and accurately”
(Dec 7) EurekAlert! reports, “Rapid and accurate diagnosis of infectious diseases helps public health officials manage disease outbreaks and enables health care providers to prescribe the correct treatment early on.”

“Gene-bender Proteins May Sway To DNA”
(Dec 6) Medical News Today reports, “Among the many genes packed into each cell of our body, those that get turned on, or expressed, are the ones that make us who we are.” 

“STAR*D study examines effect of genetic variation in treatment resistant depression” This reference links to a non-governmental website
(Dec 6) EurekAlert! reports, “Researchers are now better able to predict which patients will respond to treatment for depression through the presence of genetic markers, according to results from a major NIH study on treatment resistant depression released today at the annual meeting of the American College of Neuropsychopharmacology.”

“'Diabetes gene' may be linked to polycystic ovary syndrome” This reference links to a non-governmental website
(Dec 6) EurekAlert! reports, “Polycystic ovary syndrome (PCOS) occurs when ovarian cysts block a woman's normal ovulation and menstrual cycle. While the problem sounds straightforward, the disease is complex, born from both multiple genetic components and environmental factors.”

“Japan scientists find gene linked to heavy smoking” This reference links to a non-governmental website  (last accessed 2/2008)
(Dec 5) digitaljournal reports, “A team of Japanese scientists have found a gene closely linked to nicotine addiction, which could lead to more effective ways for smokers to kick the habit, a Japanese daily said on Wednesday.”

“Study uncovers mutation responsible for Noonan Syndrome” This reference links to a non-governmental website
(Dec 4) EurekAlert! reports, “Scientists have discovered that mutations in a gene known as SOS1 account for many cases of Noonan syndrome (NS), a common childhood genetic disorder which occurs in one in 1,000-2,500 live births.”

“Peering into the shadow world of RNA” This reference links to a non-governmental website
(Dec 4) EurekAlert! reports, “The popular view is that DNA and genes control everything of importance in biology.”

“The Strangest Song -- The story of the link between a rare genetic disorder and musical talent” This reference links to a non-governmental website
(Dec 4) EurekAlert! reports, “Gloria Lenhoff, age 51, can't make change for a dollar, or subtract five from twelve, or tell left from right.”

“Scientists find genetic key to some breast cancers” This reference links to a non-governmental website
(Dec 4) Guardian Unlimited reports, “Cancer specialists will announce today that they have discovered a gene which may hold the key to a treatment for up to 10% of all breast cancers.”

“Novel Suicide Gene Therapy Used To Treat Malignant Brain Tumors” This reference links to a non-governmental website
(Dec 3) Medical News Today reports, “Physicians and researchers in the Methodist Neurological Institute (NI) are studying the use of a novel combination of radiation and suicide gene therapy to treat typically stubborn malignant brain tumors.”

“Ped Med: Autism research shifts to biology” This reference links to a non-governmental website
(Dec 2) Science Daily reports, “Researchers endeavoring to track autism to its core are shifting more of their attention from psychology to biology.”

“Genomic 'Firestorms' Underlie Aggressive Breast Cancer Progression” This reference links to a non-governmental website
(Dec 1) Science Daily reports, “The first high-resolution analysis of genomic alterations in breast tumors is reported today in the scientific journal Genome Research. In this analysis, scientists from Cold Spring Harbor Laboratory, in collaboration with researchers from Scandinavia, identified three distinct patterns of genomic variation that underlie breast tumor formation, one of which--'firestorms'--may be predictive of aggressive disease progression and short survival.”

“'Cancer Prognosis Gene' Found To Control The Fate Of Breast Cells” This reference links to a non-governmental website
(Dec 1) Science Daily reports, “Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome.”

“Link Between Huntington's And Abnormal Cholesterol Levels Discovered In Brain” This reference links to a non-governmental website
(Dec 1) Science Daily reports, “Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington's disease affects the brain.”

“Research finds kids in northern Nevada leukemia cluster have gene variation” This reference links to a non-governmental website (last accessed 3/2007)
(Nov 30) CHealth reports, “Children in a northern Nevada leukemia cluster are more likely to have a variation in a gene that helps combat unsafe chemicals, and more research is needed to learn why, federal researchers said Thursday.”

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Genomics in Scientific Literature
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Public awareness of the existence of inherited high cholesterol
van den Nieuwenhoff HW, et al.
Eur J Cardiovasc Prev Rehabil 2006 Dec;13(6):990-2

FINDbase: a relational database recording frequencies of genetic defects leading to inherited disorders worldwide
van Baal S, et al.
Nucleic Acids Res 2006 Nov

SNP@Ethnos: a database of ethnically variant single-nucleotide polymorphisms
Park J, et al.
Nucleic Acids Res 2006 Nov

Unraveling A Complex Genetic Disease: Age-related Macular Degeneration
Chamberlain M, et al.
Surv Ophthalmol 2006 Nov-2006 Dec;51(6):576-86

Genomics and complex liver disease: Challenges and opportunities
Juran BD & Lazaridis KN
Hepatology 2006 Nov;44(6):1380-90

Single nucleotide polymorphism array analysis of cancer
Dutt A & Beroukhim R
Curr Opin Oncol 2007 Jan;19(1):43-9

Genetic and Functional Evidence Supporting SUMO4 as a Type 1 Diabetes Susceptibility Gene
Wang CY, et al.
Ann N Y Acad Sci 2006 Oct;1079:257-67

Genes influencing innate and acquired immunity in type 1 diabetes and latent autoimmune diabetes in adults
Sanjeevi CB
Ann N Y Acad Sci 2006 Oct;1079:67-80

Why is type 1 diabetes uncommon in Asia?
Park Y
Ann N Y Acad Sci 2006 Oct;1079:31-40

The type 1 diabetes genetics consortium
Rich SS, et al.
Ann N Y Acad Sci 2006 Oct;1079:1-8

Improved breast cancer prognosis through the combination of clinical and genetic markers
Sun Y, et al.
Bioinformatics 2006 Nov

A public health genetic approach for schizophrenia
Danese A
Epidemiol Psichiatr Soc 2006 Jul-2006 Sep;15(3):185-93

Potential for genetics to promote public health: genetics research on smoking suggests caution about expectations
Carlsten C & Burke W
JAMA 2006 Nov;296(20):2480-2

Pharmacogenetics and diseases of the colon
Hisamuddin IM, et al.
Curr Opin Gastroenterol 2007 Jan;23(1):60-6

The genetics of bipolar affective disorder
Farmer A, et al.
Curr Opin Psychiatry 2007 Jan;20(1):8-12

Surfactant protein polymorphisms and neonatal lung disease
Hallman M & Haataja R
Semin Perinatol 2006 Dec;30(6):350-61

Schizophrenia, human genetics and genetic counselling : Human genetic counselling as part of the psychiatric/psychotherapeutic treatment concept
Knoblauch H
Nervenarzt 2006 Dec

The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactions
Haddad A, et al.
Support Care Cancer 2006 Dec

Genetics of autoimmune diseases - disorders of immune homeostasis
Gregersen PK & Behrens TW
Nat Rev Genet 2006 Dec;7(12):917-28

Evolution and respiratory genetics
Le Souef PN, et al.
Eur Respir J 2006 Dec;28(6):1258-63

Family History
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“Genetic Susceptibility And Inherited Tendencies In The Occurrence And Treatment Of Blood
Cancer”
This reference links to a non-governmental website
(Dec 7) Medical News Today reports, “People who are born with or develop specific genetic mutations may be prone to certain blood cancers, and some inherited genes associated with cancer apparently cluster within families.”

“Wanting Babies Like Themselves, Some Parents Choose Genetic Defects” This reference links to a non-governmental website
(Dec 5) New York Times reports, “Wanting to have children who follow in one’s footsteps is an understandable desire.”

“African-Americans with prostate cancer more likely to have family history of prostate, breast
cancer”
This reference links to a non-governmental website
(Dec 1) EurekAlert! reports, “African-American men with prostate cancer were more likely to report a family history of prostate cancer and breast cancer among siblings than men who did not have prostate cancer, according to researchers at the University of Michigan Comprehensive Cancer Center.”

Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden
Couturaud F, et al.
Thromb Haemost 2006 Dec;96(6):744-9

Risk of second malignant neoplasms among lymphoma patients with a family history of cancer
Landgren O, et al.
Int J Cancer 2006 Nov

Genetic Testing
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“Genetic testing may help predict excess bleeding” This reference links to a non-governmental website (last accessed 2/2008)
(Dec 6) Reuters via Iconocast reports, “Patients taking a common drug to prevent blood clots to reduce heart attack and stroke risk now rely on a doctor's determination that they will not suffer excessive bleeding.”

“Genzyme Introduces New Genetic Test To Complement Lung Cancer Portfolio” This reference links to a non-governmental website
(Dec 5) mediLexicon reports, “Genzyme Corporation announced today the commercial availability of a new laboratory test to help identify non-small cell lung cancer (NSCLC) patients who may not respond to targeted therapies.”

“Consortium of international hospitals receives $11 million to conduct study of genetic brain tumors” This reference links to a non-governmental website
(Dec 4) EurekAlert! reports, “The National Cancer Institute recently awarded The University of Texas M. D. Anderson Cancer Center an $11 million grant to lead the largest genetic study ever conducted on the causes and risk factors of adult and pediatric gliomas, or malignant, primary brain tumors.”

“Peering Into the Future” This reference links to a non-governmental website
(Dec 4) Newsweek reports, “Genetic testing is transforming medicine—and the way families think about their health. As science unlocks the intricate secrets of DNA, we face difficult choices and new challenges.”

“Father's love fuels desire to find cure for genetic disease” This reference links to a non-governmental website
(Dec 4) phillyBurbs.com reports, “John Crowley barely understood some of the words a doctor used when he was told his 15-month-old daughter and 4-month-old son had a rare and fatal genetic disease called Pompe.”

“Breakthrough Seen In Early Lung Cancer Diagnosis Research” This reference links to a non-governmental website (last accessed 2/2008)
(Dec 2) can.com reports, “Researchers from the National Research Program for Genomic Medicine (NRPGM) have discovered several genes that play a decisive role in the formation and transfer of lung cancer.”

The rhetorical construction of ethical positions: Policy recommendations for nontherapeutic genetic testing in childhood
Hogben S & Boddington P
Commun Med 2006;3(2):135-46

Genetic testing and counseling: selected ethical issues
Erlen JA
Orthop Nurs 2006 Nov-2006 Dec;25(6):423-6

Genetic testing for colon cancer
Kaz AM & Brentnall TA
Nat Clin Pract Gastroenterol Hepatol 2006 Dec;3(12):670-9

Alzheimer disease and genetics: anticipating the questions
Schutte DL
Am J Nurs 2006 Dec;106(12):40-7

Best Practice Guidelines for the Molecular Genetic Diagnosis of Type 1 (HFE-Related) Hereditary Haemochromatosis
King CM & Barton DE
BMC Med Genet 2006 Nov;7(1):81

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending December 6, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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57th Annual Meeting of the American Society of Human Genetics This reference links to a non-governmental website
October 23-27, 2007 ~ San Diego, CA
 

Advisory Committee on Heritable Disorders and Genetic Diseases in Newborns and Children
December 18-19, 2006 ~ Washington, DC

   
  2007 ACMG Annual Clinical Genetics Meeting This reference links to a non-governmental website
March 21-25, 2007 ~ Nashville, TN
   
New This Week RNA 2007 This reference links to a non-governmental website
May 29 - June 3, 2007 ~ Madison, WI
   
New This Week 38th National Conference & Exposition for the Autism Society of America This reference links to a non-governmental website
July 11-14, 2007 ~ Phoenix, AZ
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Let's Go Surfing
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Autism Society of America  This reference links to a non-governmental website
ASA is dedicated to increasing public awareness about autism and the day-to-day issues faced by individuals with autism, their families and the professionals with whom they interact. The Society and its chapters share a common mission of providing information and education, and supporting research and advocating for programs and services for the autism community.

The RNA Society  This reference links to a non-governmental website
The RNA Society was established in 1993 to facilitate sharing and dissemination of experimental results and emerging concepts in RNA research.

Public Health Genomics Program  This reference links to a non-governmental website
The Michigan Public Health Genomics Program (PHGP) is a multi-disciplinary program that provides assessment, policy development, and assurance related to birth defects, genetic disorders, and the use of genomics in public health programs.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: December 7, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics