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 Thursday, August 31, 2006     Volume 17   Number 9  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
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Welcome to the National Office of Public Health Genomics
As of July 24, 2006, the CDC has changed the name of our office to the National Office of Public Health Genomics.

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CDC Announcements
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CDC sponsored event

CDC's 2006 National Health Promotion Conference
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic disease, and genomics. Registration is now open.

   
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New HuGE Review
Association between Apolipoprotein E Polymorphisms and Age-related Macular
Degeneration
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Ammarin Thakkinstian, et al.
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Breakthrough flu test speeds up diagnosis, pinpoints strain” 
(Aug 29) Seattlepi.com reports, “In an advance that speeds up diagnosis of the most dangerous avian flu, scientists have developed a detailed influenza test that takes less than 12 hours, federal health officials said Monday.”

“Live long? Die young? Answer isn't just in genes” This reference links to a non-governmental website
(Aug 31) International Herald Tribune reports, “Josephine Tesauro never thought she would live so long.”

“China builds biggest gene bank of all 54 ethnic minorities” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 31) 4 ethnic minorities, the state media reported today.”

“Covert DNA analysis to be illegal in UK”  This reference links to a non-governmental website
(Aug 30) English Peoples Daily Online reports, “Covertly analyzing someone's DNA will be illegal from Friday next week in the United Kingdom on the recommendation of the Human Genetics Commission (HGC) to the UK government, New Scientist reported on its website on Tuesday.”

“Brave New World of Genes and Bytes” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 29) OhmyNews reports, “We all know Craig Venter: 50-something 24-carat genius who after years of extraordinary research and teaching at the prestigious National Institutes of Health founded The Institute for Genomic Research (TIGR) in 1992 and with the talent he assembled there became the first to decode the genome of a free-living organism -- a disease-causing bacterium.”

“Hopkins Develops Online Tool To Aid Research On Certain 'Orphan Diseases'” This reference links to a non-governmental website
(Aug 29) Bioresearch Online reports, “Many people are afflicted with rare illnesses of unknown cause, and finding a common link to such under-studied or "orphaned" diseases as Bardet-Biedl, Alstrom and Meckel-Gruber syndromes can significantly advance the search for causes and treatment.”

“Older twins to shed light on ageing” This reference links to a non-governmental website
(Aug 29) ninemsn reports, “An Australian study involving 300 sets of older twins is expected to reveal new genes which control how humans age.”

“Genome Institute Turns To Sun's Opteron Servers To Get Gene-Sequencing Done” This reference links to a non-governmental website
(Aug 28) Yahoo News reports, “Sun Microsystems has succeeded in displacing aging H-P Alpha servers with its Opteron-based line of servers in what is an acknowledged, compute-intensive environment—The Institute for Genomic Research.”

“Gene Variations May Increase Stroke Risk For Younger Women” This reference links to a non-governmental website
(Aug 28) Science Daily reports, “University of Maryland researchers have shown a strong association between specific genetic variations and an increased risk of stroke in younger women, adding to the growing evidence of possible genetic influences in stroke.”

“Age-Linked Vision Loss May Depend on Genes” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 28) CBC News reports, “Genetics plays a big role in age-related macular degeneration (AMD), the leading cause of vision loss in older adults, two new studies show.”

“University of Pittsburgh named Parkinson Disease Center for Advanced Research” This reference links to a non-governmental website
(Aug 28) EurekAlert! reports, “The University of Pittsburgh has been named an American Parkinson Disease Association (APDA) Advanced Center for Parkinson's Disease Research, a designation that places it in an elite group with eight other leading institutions in the United States.”

“Gene for age-related hearing loss” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 28) tehrantimes.com reports, “Hearing loss in the elderly has been linked to flaws in a specific gene in a study by Dutch researchers.”

“NUH team discovers how gene affects drug dosage” This reference links to a non-governmental website
(Aug 28) Channel News Asia reports, “Singapore doctors have solved the puzzle of why Indian, Chinese and Malay patients need different dosages of the commonly-used anti-clotting drug - warfarin - to achieve the same effect, raising the possibility that medicine, in the future, could be prescribed based on ethnicity.”

“Gene-on-gene interactions may influence risk for developing alcoholism” This reference links to a non-governmental website
(Aug 27) EurekAlert! reports, “One variant of the alcohol dehydrogenase gene can influence alcohol response among some Caucasians.”

“Understanding Genetic Disorders” This reference links to a non-governmental website
(Aug 25) Health Scout reports, “You may not have ever heard of Marfan syndrome, Ehlers-Danlos or Loeys-Dietz syndrome. Not many physicians have the chance to regularly work with these extremely rare genetic conditions.”

“NIH unprecedented genetic study may help identify people most at risk for alcoholism” This reference links to a non-governmental website
(Aug 25) EurekAlert! reports, “Scan of human genome may provide important new tools for prevention and treatment.”

“Gene variants reveal susceptibility to cardiovascular disease” This reference links to a non-governmental website
(Aug 24) EurekAlert! reports, “Variations in a gene that acts as a switch to turn on other genes may predispose individuals to heart disease, an international team of researchers led by Duke University Medical Center scientists has discovered.”

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Genomics in Scientific Literature
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Mechanisms of Disease: genetic susceptibility and environmental triggers in the development of rheumatoid arthritis
Klareskog L, et al.
Nat Clin Pract Rheumatol 2006 Aug;2(8):425-33

Defining the genetic aetiology of monogenic diabetes can improve treatment
Gloyn AL & Ellard S
Expert Opin Pharmacother 2006 Sep;7(13):1759-67

Unraveling the complex genetics of familial combined hyperlipidemia
Suviolahti E, et al.
Ann Med 2006;38(5):337-51

Idiopathic thrombocytopenic purpura (ITP): Is there a genetic predisposition?
Rischewski JR, et al.
Pediatr Blood Cancer 2006 Aug;47(S5):678-80

Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate?
Brockton NT
Cancer Causes Control 2006 Oct;17(8):1005-16

Host susceptibility to persistent hepatitis B virus infection
He YL, et al.
World J Gastroenterol 2006 Aug;12(30):4788-93

The impact of host pharmacogenetics on antiretroviral drug disposition
Owen A
Curr Infect Dis Rep 2006 Sep;8(5):401-8

Family History
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“Researchers look at genetic, environmental factors behind cleft lips” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 30) Jewish World Review reports, “Most people think the jagged white line on Michaela Skiles' upper lip is a scar from an accident. They never suspect that Skiles, 34, was born with a cleft lip.”

“Genetic testing for colon cancer: Should you consider it?” This reference links to a non-governmental website
(Aug 29) Mayo Clinic.com reports, “Find out if your family's history of colon cancer indicates you might have a genetic link and what to consider when it comes to genetic testing.”

“Family medical history can help avoid diseases”
(Aug 28) Richmond Times Dispatch reports, “If Daddy died of a heart attack and Mommy had a stroke, you ought to keep yourself fit and lean.”

“Kids' fracture risk may have a genetic link”
(Aug 25) Macleans.ca reports, “Some children may have a genetic predisposition toward breaking their bones, according to a Canadian study that compared the family histories of young fracture patients and healthy kids.”

Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
Carr DB, et al.
Diabetes Care 2006 Sep;29(9):2078-83

Childhood Cancer in Families with and without BRCA1 or BRCA2 Mutations Ascertained at a High-Risk Breast Cancer Clinic
Brooks GA, et al.
Cancer Biol Ther 2006 Sep;5(9)

Influence of familial cancer history on lymphoid neoplasms risk validated in the large European case-control study epilymph
Casey R, et al.
Eur J Cancer 2006 Aug

Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer
Karppinen SM, et al.
Eur J Cancer 2006 Aug

Genetic Testing
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“Prenatal diagnostic tests have low risk of miscarriage” This reference links to a non-governmental website
(Aug 31) News-Medical.Net reports, “Pregnant women who seek prenatal diagnostic testing to identify genetic or chromosomal abnormalities have a lower risk of miscarriage than previously believed, according to a UCSF study.”

“Ohio adds two genetic-disorder screenings at birth” This reference links to a non-governmental website
(Aug 29) The Plain Dealer reports, “Starting Wednesday, having a baby in Ohio will cost more. But for a few families, the increased cost may be worth it.”

Diagnostic testing of genetic disorders: limiting the scope of patent claims through disclosure requirements
Abbot J
J Law Med 2006 Aug;14(1):110-26

Parental attitudes to the identification of their infants as carriers of cystic fibrosis by newborn screening
Lewis S, et al.
J Paediatr Child Health 2006 Sep;42(9):533-7

Breast cancer susceptibility testing: past, present and future
Goldberg JI & Borgen PI
Expert Rev Anticancer Ther 2006 Aug;6(8):1205-14

Obtaining Informed Consent for Genetic Studies
Green D, et al.
Am J Epidemiol 2006 Aug

Newborn screening for metabolic disorders
Waisbren SE
JAMA 2006 Aug;296(8):993-5

On attitudes about colorectal cancer screening among gastrointestinal specialists and general practitioners in the Netherlands
Terhaar Sive Droste JS, et al.
World J Gastroenterol 2006 Aug;12(32):5201-4

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 30, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

From Human Genetic Variations to Prediction of Risks and Responses to Drugs and the Environment This reference links to a non-governmental website
September 29 - October 2, 2006 ~ Santorini Island, Greece

New this week Advances in Microarray Technology 2006This reference links to a non-governmental website (last accessed 2/2008)
October 31- November 2, 2006 ~ Amsterdam, Netherlands
   
New this week Pathway Biology in MedicineThis reference links to a non-governmental website (last accessed 2/2008)
November 9, 2006 ~ Edinburgh, United Kingdom
   
New this week Biotecnología Habana 2006This reference links to a non-governmental website
November 13-16, 2006 ~ Havana, Cuba
   
New this week From Genomes to Protective Antigens: Designing VaccinesThis reference links to a non-governmental website
November 15-17, 2006 ~ Prague, Czech Republic
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Let's Go Surfing
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PDQ®
PDQ (Physician Data Query) is NCI's comprehensive cancer database with peer-reviewed summaries on cancer treatment, screening, prevention, genetics, and supportive care, and complementary and alternative medicine

Useful Links
Presented by the National Cancer Institute on important genetic and genomic concepts

Your Family HistoryThis reference links to a non-governmental website
March of Dimes

Cancer Genetics Services Directory
This directory, provided by the National Cancer Institute, lists professionals who provide services related to cancer genetics (cancer risk assessment, genetic counseling, genetic susceptibility testing, and others).

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: August 31, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics