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 Thursday, August 24, 2006     Volume 17   Number 8  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
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Welcome to the National Office of Public Health Genomics
As of July 24, 2006, the CDC has changed the name of our office to the National Office of Public Health Genomics.

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CDC Announcements
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CDC sponsored material

CDC Science Ambassador Program: High school lesson plan topics related to public health genomics

   
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Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases You will need a free Acrobat player to view this file(90KB)
John P. A. Ioannidis, Thomas A. Trikalinos and Muin J. Khoury

   
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Familial risk assessment for early-onset coronary heart disease You will need a free Acrobat player to view this file(219KB)
Scheuner MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ.
Genet Med. 2006 Aug;8(8):525-531

   
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Expanding the definition of a positive family history for early-onset coronary heart disease You will need a free Acrobat player to view this file(318KB)
Scheuner MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ.
Genet Med. 2006 Aug;8(8):491-501

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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 “CDC Releasing Gene Blueprints” This reference links to a non-governmental website
(Aug 23) latimes.com reports, “U.S. health officials have placed the genetic blueprints of more than 650 flu viruses into a public database, in an attempt to increase flu research and set an example for other nations.”

“Genes 'responsible for cot death'” This reference links to a non-governmental website
(Aug 24) netdoctor.co.uk reports, “Cot death could be the result of genetic faults causing mild lung abnormalities, researchers have claimed.”

“Largest review of Loeys-Dietz Syndrome to date” This reference links to a non-governmental website
(Aug 23) EurekAlert! reports, “Identification of more genetic perturbations paints clearer picture for diagnosis.”

“Under Certain Genetic Circumstances, Naltrexone May Increase the Urge to Drink” This reference links to a non-governmental website
(Aug 23) The Westminster News reports, “Naltrexone (NTX) is able to reduce drinking and craving among many alcoholics and heavy drinkers, but not all of them.”

“NHGRI Awards $54 Million to Three Centers of Excellence in Genomic Science” This reference links to a non-governmental website
(Aug 22) NIH News reports, “The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced grants totaling $54 million over five years to establish one new Center of Excellence in Genomic Science (CEGS) and continue support for two existing centers.”

“Oakland: Genetics pioneer to visit” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 22) post-gazette.com reports, “Genetics pioneer Gerald R. Fink will lecture at noon Sept. 7 on the influence of repeated DNA sequences for the third installment of the 2006 Senior Vice Chancellor's Laureate Lecture Series at the University of Pittsburgh.”

“Geneticists Make Progress Against Ovarian Cancer”  (last accessed 2/2008)
(Aug 21) HealthDay News via healthfinder.gov reports, “Canadian researchers say they've created a new model to identify ovarian cancer genes, a big step toward improving treatment for the disease.”

“Half a million Britons set for DNA disease quest”
(Aug 21) Yahoo News reports, “A project to collect DNA samples from half a million Britons to unpick the genetic basis of killer diseases including cancer got the go-ahead on Tuesday, marking the start of the world's biggest medical experiment.”

“Major Genetic Risk Factor for Prostate Cancer” This reference links to a non-governmental website
(Aug 21) Health Scout reports, “Scientists may be one step closer to understanding why prostate cancer is more common in African Americans.”

“Scripps research team reverses Friedreich's ataxia defect in cell culture” This reference links to a non-governmental website
(Aug 21) EurekAlert! reports, “Newly developed compounds activate silenced gene responsible for debilitating disease.”

“Gene tied to high preemie rate among black women” This reference links to a non-governmental website (last accessed 3/2007)
(Aug 21) Reuters Health via realHealth reports, “A gene variant appears to be one reason why African American women are two to three times more likely than white women to have a premature baby.”

“Common Genetic Prostate Cancer Variant Is Identified” This reference links to a non-governmental website
(Aug 21) mediLexicon reports, “Prostate cancer (CaP) is a presumed result of both genetic and environmental events.”

“'Signature' of chromosome instability predicts cancer outcomes” This reference links to a non-governmental website
(Aug 20) EurekAlert! reports, “Microscopic examination of tumor specimens cannot always predict a cancer's aggressiveness, leading to increased interest in molecular approaches to diagnosis.”

“Mental health, genetic links dividing experts” This reference links to a non-governmental website
(Aug 20) Fort Wayne.com reports, “One percent of all Americans – about 2.4 million people – have schizophrenia.”

“A Massive Search for Autism Genes Begins” This reference links to a non-governmental website
(Aug 19) Technology Review reports, “The hunt for the genetic basis of autism may soon be closing in on its elusive target.”

“Core needle biopsy gives an accurate picture of gene expression in whole tumor” This reference links to a non-governmental website
(Aug 17) EurekAlert! reports, “The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour.”

“Genetic Study To Determine Why Small Group Of HIV Patients Doesn't Get Sick” This reference links to a non-governmental website
(Aug 17) 365gay reports, “They are medical mysteries, medical marvels -positive people who, long after being infected with the virus that causes AIDS, do not progress to illness.”

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Genomics in Scientific Literature
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Familial Relative Risk Estimates for Use in Epidemiologic Analyses (last accessed 3/2007)
Yasui Y, et al.
Am J Epidemiol 2006 Aug

Relevance of the Deletion Polymorphisms of the Glutathione S-Transferases GSTT1 and GSTM1 in Pharmacology and Toxicology
Bolt HM & Thier R
Curr Drug Metab 2006 Aug;7(6):613-28

Simultaneous estimation of gene-gene and gene-environment interactions for numerous loci using double penalized log-likelihood
Tanck MW, et al.
Genet Epidemiol 2006 Aug

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young
Ellard S & Colclough K
Hum Mutat 2006 Aug;27(9):854-69

Early Alzheimer's disease genetics
Schellenberg GD
J Alzheimers Dis 2006 Aug;9(3 Suppl):367-72

Acute health events in adult patients with genetic disorders: The Marshfield Epidemiologic Study Area
Giampietro PF, et al.
Genet Med 2006 Aug;8(8):474-90

Arterial thrombosis resulting in amputation in a child with poorly controlled type 1 diabetes and heterozygous Factor V Leiden mutation
Haller MJ, et al.
Pediatr Diabetes 2006 Aug;7(4):229-31

Making sense of puzzling genetic association studies: a team approach
Lee JS & Tucker MA
Ann Intern Med 2006 Aug;145(4):302-4

Genetics in eating disorders: extending the boundaries of research
Pinheiro AP, et al.
Rev Bras Psiquiatr 2006 Aug

Candidate Single Nucleotide Polymorphism Selection using Publicly Available Tools: A Guide for Epidemiologists
Bhatti P, et al.
Am J Epidemiol 2006 Aug

Family History
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“Major new osteoporosis study to recruit people in Orkney” This reference links to a non-governmental website
(Aug 23) EurekAlert! Reports, “Up to 2,000 people from the remote Isles of Orkney, Scotland are to be recruited onto a major new study, which aims to identify the genes that cause the common bone-thinning condition, osteoporosis.”

Familial study of chronic lymphocytic leukemia: aggregation of different malignant processes in families with individuals affected with chronic lymphocytic leukemia (last accessed 3/2007)
Nenova IS, et al.
Folia Med (Plovdiv) 2006;48(1):11-6

Familial aggregation of fainting in a case-control study of neurally mediated hypotension patients who present with unexplained chronic fatigue
Lucas KE, et al.
Europace 2006 Aug

Family and personal history in colorectal cancer patients: what are we missing?
Alberto VO, et al.
Colorectal Dis 2006 Sep;8(7):612-4

Familial Occurrence of Dementia and Parkinsonism. A Systematic Review
Kurz MW, et al.
Dement Geriatr Cogn Disord 2006 Aug;22(4):288-95

Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease
Zeitlin AA, et al.
Clin Endocrinol (Oxf) 2006 Sep;65(3):380-4

Genetic Testing
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“Genetics for the DIY set” This reference links to a non-governmental website
(Aug 21) latimes.com reports, “Will I get cancer? Should I take zinc? At-home gene tests say they'll tell you—but their advice is often suspect.”

“Genetic testing links to EMRs” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 18) Healthcare IT News reports, “Hospitals will now be able to complete on-site genetic testing and integrate that data with their own information systems as a result of a new technology partnership between Cerner Corp, Protedyne and Correlagen Diagnostics, Inc.”

“Most Americans Strongly Support Using Genetic Data for Some Uses” This reference links to a non-governmental website
(Aug 18) The Wall Street Journal Online reports, “A large majority of Americans strongly support using genetic information gleaned from DNA tests for medical, law enforcement and personal use, but many also strongly oppose the data's use by insurers and employers, a Wall Street Journal Online/Harris Interactive poll shows.”

Genes on the Web--direct-to-consumer marketing of genetic testing
Wolfberg AJ
N Engl J Med 2006 Aug;355(6):543-5

Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospective cohort study
Phillips KA, et al.
Clin Genet 2006 Sep;70(3):198-206

DNA testing, banking, and genetic privacy
Roche PA & Annas GJ
N Engl J Med  2006 Aug;355(6):545-6.

Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung cancer
Soh J, et al.
Int J Cancer 2006 Aug

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 23, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Aging Research in Immunology This reference links to a non-governmental website (last accessed 2/2008)
September 4-5, 2006 ~ Paris, France

 

Gene Therapy for Inherited Deficiencies: Advances and Safety Issues
September 18-19, 2006 ~ Bethesda, MD

   
  ABC Transporters and Genetic Disease
September 28-29, 2006 ~ Frederick, MD
   
  Molecular Genetics of Aging
October 4-8, 2006 ~ Cold Spring Harbor, NY
   
  NCRI Cancer Conference This reference links to a non-governmental website
October 8-11, 2006 ~ Birmingham, UK
   
  The American Society of Human Genetics 56th Annual Meeting
October 9-13, 2006 ~ New Orleans, Lousiana
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Let's Go Surfing
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Genes, Behavior, and the Social Environment: Moving Beyond the Nature/Nurture Debate  This reference links to a non-governmental website
This new report was release on August 16, 2006 by the Institute of Medicine

Genetic Analysis Course (Video Casts) 
Genetic Analysis Course-2 day course webcasts and slides on basics of genetic and genetic analysis in clinical and  epidemiology, offered by the Core Genotyping Facility in the Division of Cancer Epidemiology and Genetics at NCI.

Cancer Genetic Markers of Susceptibility 
The Cancer Genetic Markers of Susceptibility (CGEMS) is a three-year NCI initiative that will identify genetic alterations that make people susceptible to prostate and breast cancer.

Human Genome Browser Gateway from the University of California in Santa Cruz This reference links to a non-governmental website
The Browser stacks annotation tracks beneath genome coordinate positions, allowing rapid visual correlation of different types of information. The user can look at a whole chromosome, open a specific cytogenetic band to see a positionally mapped disease gene candidate, or zoom in to a particular gene.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: August 24, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics