Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 
     
 Thursday, April 27, 2006     Volume 16   Number 17  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
view the current Update
collage of images in a circle At A Glance - CDC's Office of Genomics and Disease Prevention you will need a free Acrobat player to view this file (461KB)
Presents an overview of public health genomics at CDC.
line
   
CDC Announcements
back to top
bullhorn
What’s New in HuGENet™
April 2006
   
bullhorn
Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now. Places are limited.
 
CDC sponsored material
A public health approach to pharmacogenomics and gene-based diagnostics
you will need a free Acrobat player to view this file (335KB)
Davis R and Khoury MJ.  Pharmacogenomics, April 2006
line
Genomics In The News
back to top
  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
light bulb
Featured item
“Chronic fatigue may have genetic basis”  
(April 20) Reuters Health reports, “Results from the largest study of chronic fatigue syndrome to date suggests that there are specific genes and gene activity patterns that make some people more prone to develop the disorder.”

“Oncogenic genes hamper therapy”This reference links to a non-governmental website 
(April 27) The Star reports, “Scientists believe they have shed new light on how a gene therapy, initially thought to be a miracle cure for children born with a devastating immune disorder, went disastrously wrong.”

“Gene variations linked to brain aneurysms”This reference links to a non-governmental website 
(April 26) EurekAlert! reports, “The interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are related to cerebral aneurysms.”

“Case Law School receives $773,000 NIH grant to develop guidelines for genetic enhancement research”This reference links to a non-governmental website 
(April 26) EurekAlert! reports, “A Case Western Reserve University law professor has been awarded a $773,000 grant from the National Institutes of Health to develop guidelines for the use of human subjects in what could be the next frontier in medical technology – genetic enhancement.”

“Study zeroes in on genes for opiate dependence”
(April 26) Reuters Health reports, “Researchers are a step closer to identifying the genes that make some people more likely to become addicted to heroin, morphine and similar drugs.”

“Genetic Test to Give Clues on Treatment of Hepatitis C”This reference links to a non-governmental website 
(April 26) The New York Times reports, “Celera Genomics plans to announce today that it has developed a genetic test it says can help predict which patients with hepatitis C will eventually suffer liver scarring and so are in most need of treatment.”

“In Chemical Genetics, A New Strategy Could Speed Drug Discovery”This reference links to a non-governmental website 
(April 26) Medical News Today reports, “Researchers at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics.”

“The Nowgen Centre, Multi-million Pound Centre For Genetics Research Launched, UK”This reference links to a non-governmental website 
(April 26) Medical News Today reports, “The Nowgen Centre, the new multi-million pound, Manchester-based centre for genetics in healthcare and home of the North West Genetics Knowledge Park, will be officially opened on 25 April by Dr John Stageman, Vice President for Global Sciences and Information at AstraZeneca.”

“Genetic Information to Stop Breast and Ovarian Cancer Launches Two Websites”This reference links to a non-governmental website 
(April 25) PR Web reports, “A young woman in the prime of her life who developed breast cancer due to a genetic predisposition to cancer desires to break the cycle of hereditary breast and ovarian cancer by raising one’s awareness of the benefits of genetic testing.”

“Blood cancers may be caused by inactivation of a "tumor suppressor" gene”This reference links to a non-governmental website 
(April 25) News-Medical.Net reports, “Inactivation of a "tumor suppressor" gene could be a major cause of a class of blood cancers called diffuse large B-cell lymphomas, reports a team of researchers at the Weill Medical College of Cornell University.”

“Genetic finding suggests alternative treatment strategy for common, complex skin disorders”This reference links to a non-governmental website 
(April 25) EurekAlert! reports, “A genetic finding by researchers at the National Institutes of Health provides new insight into the cause of a series of related, common and complex illnesses – including hay fever and asthma as well as the skin disorders eczema and psoriasis – and suggests a novel therapeutic approach.”

“National DNA Day Essay Contest and Survey Highlight Need for Genetic Science Education”This reference links to a non-governmental website 
(April 25) Yahoo reports, “In commemoration of National DNA Day, the American Society of Human Genetics (ASHG), the Genetics Society of America (GSA) and Applied Biosystems (NYSE: ABI - News), an Applera Corporation business, today announced the winners of the first National DNA Day high school essay contest as part of an expanded effort to help raise awareness among the general public, students and teachers about the need for more extensive genetic science education and the value of human genetics research.”

“What do your genes mean?”This reference links to a non-governmental website 
(April 25) myDNA reports, “For generations, grandmothers have reminded younger family members that certain illnesses "run in the family.”

“Finding key to rapid aging syndrome”This reference links to a non-governmental website 
(April 24) myDNA reports, “A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.”

“Reversing cancer”This reference links to a non-governmental website 
(April 24) myDNA reports, “Cancer researchers at Sydney's Garvan Institute, in collaboration with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies.”

“New title on nutritional genomics now available” This reference links to a non-governmental website 
(April 24) EurekAlert! reports, “Understanding how diet affects individuals in human populations will revolutionize the agriculture, food, and health care industries.”

“Study first to show potential of light-activated gene therapy for knee injuries”This reference links to a non-governmental website 
(April 24) EurekAlert! reports, “An early study has demonstrated for the first time that laser light can target gene therapy right up to the edge of damaged cartilage, while leaving nearby healthy tissue untouched, according to an article published in the April edition of the Journal of Bone and Joint Surgery.”

“Joslin's C. Ronald Kahn, MD, to discuss genetics of obesity at AACE meeting”This reference links to a non-governmental website 
(April 24) EurekAlert! reports, “C. Ronald Kahn, M.D., President of Joslin Diabetes Center in Boston and the Mary K. Iacocca Professor of Medicine at Harvard Medical School, will discuss his latest research on the genetics of obesity at the 15th Annual Meeting & Clinical Congress of the American Association of Clinical Endocrinologists (AACE), being held Wednesday, April 26 , through Sunday, April 30, at the Hyatt Regency in Chicago.”

“Heart shape determines cardiac disease?”This reference links to a non-governmental website 
(April 24) myDNA reports, “Researchers at the Mayo Clinic have discovered two distinct heart shapes that correlate with mutations associated with hypertrophic cardiomyopathy (HCM).”

“Both alcoholism and chronic smoking can damage the brain's prefrontal cortex”This reference links to a non-governmental website 
(April 23) EurekAlert! reports, “Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region.”

“Penn researchers discover gene that creates "second skeleton" bone disorder”This reference links to a non-governmental website 
(April 23) News-Medical.Net reports, “Researchers at the University of Pennsylvania School of Medicine have located the "skeleton key," a gene that, when damaged, causes the body's skeletal muscles and soft connective tissue to undergo a metamorphosis into bone, progressively locking joints in place and rendering movement impossible.”

“First SCID gene chip to be introduced at Academy meeting on immunodeficiencies”This reference links to a non-governmental website 
(April 21) EurekAlert! reports, “The first gene chip ever to be developed for detecting SCID (primary immunodeficiency) in newborns will be presented to researchers for the first time at the New York Academy of Sciences' and Jeffrey Modell Foundation's one-day conference, Primary Immunodeficiencies: Past, Present, Future.”

“Research team to examine impact of genetics and exposure to secondhand smoke”This reference links to a non-governmental website (last accessed 2/2008)
(April 21) Medical College of Georgia reports, “Whether exposure to secondhand smoke increases the chance that children with a family history of cardiovascular disease will develop the disease themselves is under study at the Medical College of Georgia.”

“A Broken Stress Response System Can Contribute to Gleevec Resistance”This reference links to a non-governmental website 
(April 20) EurekAlert! reports, “New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.”

“DNAPrint Genomics Receives Notice of Allowance for Patent for Identifying Links Between Gene Sequences and Medical Traits”This reference links to a non-governmental website (last accessed 2/2008)
(April 20) Yahoo Finance reports, “DNAPrint Genomics, Inc. (OTC BB:DNAG.OB - News) today announced that the Company has received a Notice of Allowance from the U.S. Patent and Tradmark Office for a patent application, Methods for the Identification of Genetic Features for Complex Genetics Classifiers.”

line
Genomics in Scientific Literature
back to top
light bulb
Featured item
Group ponders genomics and public health
Bosch X
JAMA 2006 Apr;295(15):1762

On Using a Cancer Center Cancer Registry to Identify Newly Affected Women Eligible for Hereditary Breast Cancer Syndrome Testing: Practical Considerations
Demarco TA, et al.
J Genet Couns 2006 Apr

Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates
Macgregor S, et al.
Nucleic Acids Res 2006;34(7):e55

Statistical methods for the analysis of genetic association studies
Zou GY
Ann Hum Genet 2006 Mar;70(Pt 2):262-76

RISCALW: A Windows Program for Risk Calculation in Families with Duchenne Muscular Dystrophy
Fischer C, et al.
Ann Hum Genet 2006 Mar;70(Pt 2):249-53

Investigating the Genetic Determinants of Cardiovascular Disease Using Candidate Genes and Meta-analysis of Association Studies
Casas JP, et al.
Ann Hum Genet 2006 Mar;70(Pt 2):145-69

Genetics of restless legs syndrome
Winkelmann J & Ferini-Strambi L
Sleep Med Rev 2006 Apr

Make it HuGE: human genome epidemiology reviews, population health, and the IJE
Smith GD, et al.
Int J Epidemiol 2006 Apr

Two-stage designs in case-control association analysis
Zuo Y, et al.
Genetics 2006 Apr

Identifying susceptibility genes for immunological disorders: patterns, power, and proof
Plenge R & Rioux JD
Immunol Rev 2006 Apr;210:40-51

Screen-positive rates and agreement among six family history screening protocols for breast/ovarian cancer in a population-based cohort of 21- to 55-year-old women
Palomaki GE, et al.
Genet Med 2006 Mar;8(3):161-8

The impact of our genes: Consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis
Fazekas F, et al.
J Neurol Sci 2006 Apr

The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases
Heidema GA, et al.
BMC Genet 2006 Apr;7(1):23

A legacy for the children - attitudes of older adults in the United Kingdom to genetic testing
Skirton H, et al.
J Clin Nurs 2006 May;15(5):565-73

line
HuGE Published Literature
back to top

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 26, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

line
Upcoming Events
back to top
light bulb
Featured item

New this week

International Congress of Immunogenomics and Immunomics This reference links to a non-governmental website (last accessed 2/2008)
October 8-12, 2006 ~ Budapest, Hungary
  Chromatin Structure & Function Gordon Research ConferenceThis reference links to a non-governmental website
May 21-26, 2006 ~ Barga, Italy
   
  Nutrigenomics and Beyond: Informing the FutureThis reference links to a non-governmental website 
June 1-2, 2006 ~ Washington, DC
   
New this week Design And Analysis Of Genetic-Based Association StudiesThis reference links to a non-governmental website (last accessed 2/2008)
October 3-7, 2006 ~ Cambridge, UK
   
  Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
line
 
Let's Go Surfing
back to top
light bulb
Featured item

Slide show: How genetic disorders are passed from parents to children This reference links to a non-governmental website 
Curly hair, dimpled cheeks, brown eyes and athletic ability — these traits run in families. So does the risk of certain diseases.

Utah Asthma Genomics Workshop April 2006
Find out more about the workshop. View presentations below:

The Many Faces of DNAThis reference links to a non-governmental website 
In support of National DNA Day, myDNA is proud to present the "Many Faces of DNA" - stories from the frontline of genetics.

National DNA Day at the Genetic Science Learning Center at the University of UtahThis reference links to a non-governmental website 

 

 

Send websites that you would like to see included in a future update to genetics@cdc.gov

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: April 27, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics