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 Thursday, April 20, 2006     Volume 16   Number 16  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Celebrate DNA Day - April 25, 2006 DNA Day - April 25, 2006
In honor of DNA Day, CDC's Office of Genomics and Disease Prevention has created a list of helpful resources for teachers and students.
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CDC Announcements
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New HuGE Review
The long QT syndrome family of cardiac ion channelopathies
Modell, Stephen M. MD, MS; Lehmann, Michael H. MD

 
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New HuGE Review
Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts

   
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From Public Health Emergency to Public Health Service: The Implications of Evolving Criteria for Newborn Screening Panels
Grosse S. et al. Pediatrics; March 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Genomic Researchers Head To New England Schools for National DNA Day” This reference links to a non-governmental website
(April 17) NIH News reports, “On April 25, the fourth annual National DNA Day, researchers and professionals from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), will serve as “DNA Day Ambassadors” and fan out across the nation, with an emphasis this year on New England, to visit dozens of high school classrooms to talk with students about genomic research and their personal experiences in this revolutionary field of science.”

“New gene analyzing method is developed” This reference links to a non-governmental website (last accessed 3/2007)
(April 20) Science Daily via vetscite.org reports, “Seattle scientists have developed a method for analyzing the Major Histocompatibility Complex of the human genome, found on chromosome 6.”

“Mayo Clinic finding may double genetic screening effectiveness for sudden death heart condition”This reference links to a non-governmental website
(April 19) EurekAlert! reports, “Currently that genetic test correctly detects HCM only 40 percent of the time. But coupled with imaging information, the detection power of the test nearly doubles, to 79 percent, says Steve Ommen, M.D., director of Mayo's HCM Clinic and co-lead investigator of the Mayo Clinic research team.”

“Researchers discover a new genetic cause of Alzheimer's disease”This reference links to a non-governmental website
(April 19) EurekAlert! reports, “Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp are the first to show that the quantity of amyloid protein in brain cells is a major risk factor for Alzheimer's disease.”

“Found in 20 percent of people of African descent: MUHC describes gene that shuts down immune system”This reference links to a non-governmental website
(April 19) EurekAlert! reports, “Montreal--Caspase-12 is a molecule with a death-wish. Found only in people of African descent, this protein shuts down our body's immune system, opening the door to potentially lethal infections.”

“New London based centre for clinical genetic research”This reference links to a non-governmental website
(April 19) News-Medical .Net reports, “Imperial College London is to take the lead in the creation of a new London based centre for clinical genetic research with a consortium of leading scientific research institutions.”

“Schizophrenia as Misstep by Giant Gene”This reference links to a non-governmental website
(April 18) The New York Times reports, “Researchers have made progress in understanding how a variant gene linked to schizophrenia may exert its influence in the brain.”

“Common Genetic Link to Obesity Is Discovered”This reference links to a non-governmental website
(April 18) The New York Times reports, “A genetic variation predisposing people to obesity has been detected by a team of researchers at Boston University and elsewhere.”

“New bacterium discovered”This reference links to a non-governmental website
(April 17) myDNA reports, “Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have discovered a new bacterium and determined that it can cause serious lymph node infections in patients with chronic granulomatous disease (CGD) — a rare immune disorder that leaves individuals susceptible to frequent and sometimes life-threatening fungal and bacterial infections.”

“'U' Researchers Link Genetic Variation To Lupus”This reference links to a non-governmental website
(April 17) wcco.com reports, “Minneapolis University of Minnesota researchers have linked a single genetic variation to lupus, a disease in which an overactive immune system attacks healthy tissue.”

“American university launches Center for Genetics in Health and Medicine”
(April 17) MenaFN.com reports, “The University of Michigan has announced the opening of the Center for Genetics in Health and Medicine, which aims to bring researchers and clinicians together in finding genetic roots of disease, AP reported.”

“Genetic testing helps diagnose Long QT syndrome”This reference links to a non-governmental website
(April 16) News Medical.net reports, “Long QT syndrome is an uncommon, and sometimes fatal, heart rhythm disorder that is often present from birth. It gets its name from the peculiar pattern of the electrocardiogram (ECG or EKG) seen in people with the disease.”

“Reading between the genetic lines”This reference links to a non-governmental website
(April 13) myDNA reports, “Aided by state-of-the-art technology, parents today can choose from a plethora of audio-visual aids, DVDs, computer games and regular old books to help their kids learn to read at an early age.”

“Cell division goes backwards”This reference links to a non-governmental website
(April 13) myDNA reports, “Gary J. Gorbsky, Ph.D., a scientist with the Oklahoma Medical Research Foundation (OMRF), has found a way to reverse the process of cell division.”

“Keck Futures Initiative Announces Grant Recipients; $1 Million Awarded for 14 Research Projects”This reference links to a non-governmental website (last accessed 1/2008)
(April 10) The National Academies reports, “The National Academies Keck Futures Initiative announced today the recipients of its 2005 Futures grants, each in the amount of $50,000 or $75,000 to support interdisciplinary research on genomics and infectious disease.”

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Genomics in Scientific Literature
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Family-based designs in the age of large-scale gene-association studies
Laird NM & Lang C
Nat Rev Genet. 2006 May;7(5):385-94

Young Adults With Family History of Coronary Heart Disease Have Increased Arterial Vulnerability to Metabolic Risk Factors. The Cardiovascular Risk in Young Finns Study
Juonala M, et al.
Arterioscler Thromb Vasc Biol 2006 Apr

Pancreatic cancer genetic epidemiology consortium
Petersen GM, et al.
Cancer Epidemiol Biomarkers Prev 2006 Apr;15(4):704-10

The Impact of Acculturation on Awareness of Genetic Testing for Increased Cancer Risk among Hispanics in the Year 2000 National Health Interview Survey
Vadaparampil ST, et al.
Cancer Epidemiol Biomarkers Prev 2006 Apr;15(4):618-23

Analysing the effect of candidate genes on complex traits: an application in multiple sclerosis
Hooper-van Veen T, et al.
Immunogenetics 2006 Apr

Epidemiological studies in the information and genomics era: experience of the Clinical Genome of Cancer Project in Sao Paulo, Brazil
Wunsch-Filho V, et al.
Braz J Med Biol Res 2006 Apr;39(4):545-53

Effects of Differential Genotyping Error Rate on the Type I Error Probability of Case-Control Studies
Moskvina V, et al.
Hum Hered 2006 Apr;61(1):55-64

How Do Women Decide? Accepting or Declining BRCA1/2 Testing in a Nationwide Clinical Sample in the United States
Sankar P, et al.
Community Genet 2006;9(2):78-86

Predicting disease genes using protein-protein interactions
Oti M, et al.
J Med Genet 2006 Apr

Candidate susceptibility genes in Alzheimer's disease are at high risk for being forgotten - they don't give peace of mind
Palotas A & Kalman J
Curr Drug Metab 2006 Apr;7(3):273-93

A public health approach to pharmacogenomics and gene-based diagnostic tests
Davis RL & Khoury MJ
Pharmacogenomics 2006 Apr;7(3):331-7

Novel susceptibility genes in inflammatory bowel disease
Noble C, et al.
World J Gastroenterol 2006 Apr;12(13):1991-9

A review on genetic testing
Xie Y & Wu MQ
Sheng Wu Gong Cheng Xue Bao 2006 Mar;22(2):338-43

Incorporating pharmacogenetics into clinical practice: reality of a new tool in psychiatry
CNS Spectr 2006 Mar;11(3):suppl 1-12; discussion suppl 13

Ethical considerations in testing workers for the -glu69 marker of genetic susceptibility to chronic beryllium disease
Silver K & Sharp RR
J Occup Environ Med 2006 Apr;48(4):434-43

Evaluation of a decision aid for families considering p53 genetic counseling and testing
Peterson SK, et al.
Genet Med 2006 Apr;8(4):226-33

The epidemiology of medium chain acyl-CoA dehydrogenase deficiency: An update
Grosse SD, et al.
Genet Med 2006 Apr;8(4):205-12

LRRK2 in Parkinson's disease: protein domains and functional insights
Mata IF, et al.
Trends Neurosci 2006 Apr

'Non-Mendelian' genetics of fetal growth
Fradin D, et al.
J Endocrinol Invest 2006;29(1 Suppl):11-5

Nutrigenomics, proteomics, metabolomics, and the practice of dietetics
Trujillo E, et al.
J Am Diet Assoc 2006 Mar;106(3):403-13

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 19, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Condition
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Genomics in Public Health: 4th International DNA Sampling Conference This reference links to a non-governmental website
June 4-7, 2006 ~ Montreal, Canada

New this week Functional Genomics and Systems BiologyThis reference links to a non-governmental website
June 21-30, 2006 ~ Cambridge, UK
   
Second Congress: International Cytogenetics and Genome SocietyThis reference links to a non-governmental website
June 25-29, 2006 ~ Canterbury, Kent, UK
   
  From Human Genetic Variations to Prediction of Risks and Responses to Drugs and the EnvironmentThis reference links to a non-governmental website
September 29 - October 2, 2006 ~ Santorini Island, Greece
   
New this week Genetic Analysis WorkshopThis reference links to a non-governmental website
November 11-15, 2006 ~ St. Pete’s Beach, FL
   
New this week Annual Scientific Meeting of the International Genetic Epidemiology Society (IGES)This reference links to a non-governmental website
November 16-17, 2006 ~ St. Pete’s Beach, FL
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Let's Go Surfing
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Use of Family History Information in Pediatric Primary Care and Public Health This reference links to a non-governmental website
CDC-Sponsored Workgroup Meeting ~ February 24-25, 2006
Presentations at the meeting discussed the current state of family history information use in pediatric settings, as well as specific conditions which may serve as models for use of family history information both in pediatric primary care and in public health.

Chromosomal Variation in ManThis reference links to a non-governmental website
A catalog of chromosomal variants and anomalies

2006 Summer Opportunities for EducatorsThis reference links to a non-governmental website
This year’s opportunities from Cold Spring Harbor include Amgen Leadership Symposium, Frontiers in Genomics, Plant Molecular Genetics, Genomics and Bioinformatics and a fellowship for Minority Faculty.

Student Camps This reference links to a non-governmental website
Student summer day camps at the Dolan DNA Learning Center of Cold Spring Harbor Laboratory are week-long genetic workshops for students from middle school through high school.

Keck Foundation:  "The Genomics Revolution: Implications for Treatment and Control of Infectious Disease".  November, 2005This reference links to a non-governmental website
Presentations,  Conference,  and Working Group Summaries

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: April 20, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics