HuGENet™ is proud to announce the deployment of an integrated, searchable knowledge base of genetic associations and human genome epidemiology, the HuGE Navigator,  designed to assist researchers working in the field of Human Genome Epidemiology. These tools can be used to determine additional research questions, find collaborators, and evaluate gene-disease associations. Please visit the main page of the HuGE Navigator   for more information.

Cumulative Evidence of Genetic Associations
The following systematic reviews examined the epidemiologic evidence between genes and diseases using a quantitative approach and were added to PubMed in October:

Assessment of cumulative evidence on genetic associations: interim guidelines. HuGE review authors are strongly encouraged to use these guidelines in conducting HuGE reviews and meta analyses.

• Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis
• Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population
• Meta-analyses of genetic studies on major depressive disorder
• Haplotypes of the estrogen receptor beta gene and breast cancer risk
• Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis
• Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
• Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-Analysis
• TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort
• Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
• Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
• Is the p53 codon 72 polymorphism a key biomarker for cervical cancer development? A meta-analysis review within European populations
• Implications for prostate cancer of IGF1 genetic variation and circulating IGF1 levels.
• Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium

Search for HuGE Reviews in the HuGE Navigator

Search for systematic reviews in the HuGE Navigator

• List of HuGE Review topics under development

Genome Wide Association Studies (GWAs)
Seventeen Genome Wide Association Studies from the Framingham Heart Study were included in a BMC Medical Genetics supplement and added to PubMed in October:

The Framingham Heart Study 100,000 single nucleotide polymorphisms resource

• Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
• Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
• Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
• Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
• A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
• Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
• Framingham Heart Study genome-wide association: results for pulmonary function measures
• Genome-wide association of sleep and circadian phenotypes
• A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study
• Genome-wide association with select biomarker traits in the Framingham Heart Study
• Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
• Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
• Genome-wide association with bone mass and geometry in the Framingham Heart Study
• Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
• Genome-wide association with diabetes-related traits in the Framingham Heart Study
• A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
• Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project

Search for genome wide association studies in the HuGE Navigator 

As of October 30, 2007, the HuGE Navigator  contains 30,379 research studies, referencing 3,085 genes,and 1,923 health outcomes/diseases. Both epidemiologic studies and review articles can be found in the database which includes 61 HuGE Reviews and 589 meta-analyses.

Provides link to non-governmental sites and does not necessarily represent the  views of the Centers for Disease Control and Prevention.