On January 24th and 25th, 2008, HuGENet™ will be hosting the HuGENet Workshop, “HuGE Networks, Genome-Wide Association Studies, and the Knowledge Base on Genetic Variation and Human Health”, at the CDC Global Communications Center in Atlanta, GA.

The HuGE Track,  a custom track that links the contents of the HuGE Navigator  to the UCSC Genome Browser  was created in November. Researchers can use this resource to visualize genes of interest and retrieve relevant articles on genetic associations.

Cumulative Evidence of Genetic Associations
The following systematic reviews examined the epidemiologic evidence between genes and diseases using a quantitative approach and were added to PubMed in November:

Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls

HuGE Reviews

• Meta-Analysis of the Association of the Taq1A Polymorphism with the Risk of Alcohol Dependency: A HuGE Gene-Disease Association Review.

• The E-cadherin Gene Polymorphism 160C->A and Cancer Risk: A HuGE Review and Meta-Analysis of 26 Case-Control Studies.

• One new HuGE Review was proposed in November:
  HFE gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis
  Ruben Hernaez, Edwina Yeung, Jeanne M. Clark, Frederick L. Brancati, and Wen Hong Linda Kao (Johns Hopkins University).

• List of HuGE Review topics under development

Other Systematic Reviews

• Association Between delta-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism and Blood Lead Levels: A Meta-regression Analysis.

• Association of adipose most abundant transcript 1 (apM1) gene with type 2 diabetes mellitus in a Chinese population: A Meta-analysis of case-control studies.

• Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids.

• Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O(6)-alkylguanine-DNA alkyltransferase.

• The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis.

• The vascular endothelial growth factor +405G>C polymorphism in endometriosis.

• Toward a major risk factor for atopic eczema: Meta-analysis of filaggrin polymorphism data.

• Association of tumor necrosis factor alpha 308 G/A gene promoter polymorphism with the presence of chronic obstructive pulmonary disease: a meta-analysis

• Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer

Search for HuGE Reviews in the HuGE Navigator
Search for systematic reviews in the HuGE Navigator

Genome Wide Association Studies (GWAs)
The following genome wide association studies were added to PubMed in November:

• Sorl1 as an Alzheimer's Disease Predisposition Gene?
• Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Search for genome wide association studies in the HuGE Navigator 

HuGENet™ Publications

The following publications were written by HuGENet collaborators and were added to PubMed in November:

• Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?

• Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls.

• An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology.

• View all HuGENet™ Publications

As of December 4, 2007, the HuGE Navigator  contains 30,905 research studies, referencing 3,102 genes,and 1,928 health outcomes/diseases. Both epidemiologic studies and review articles can be found in the database which includes 64 HuGE Reviews and 605 meta-analyses.

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