Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease
E Evangelou, DM Maraganore, and JP Ioannidis
(PLoS ONE, February 2007)

In March, a formal partnership between the journal, Gastroenterology, and HuGENet™ was announced.

• HuGE Reviews and Meta-analysis of Gene Association Studies
  H El-Serag, MJ Khoury, JD Lewis
  (Gastroenterology, March 2007)
    
  >> Gastroenterology constitutes the ninth academic journal to collaborate with HuGENet™ (view list of collaborating journals).

Two new HuGE Reviews have been posted on the HuGENet™ website since the last issue of ‘What's New':

• HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review by Hollie Schmidt, et al., from the Accelerated Cure Project for Multiple Sclerosis
  (American Journal of Epidemiology, Advance Access)

• Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review
  Eliane Kellen, et al., from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC)
  (American Journal of Epidemiology, Advance Access)

• List of completed HuGE Reviews
• List of HuGE Review topics under development

Handbook for Authors of New HuGE Reviews
HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic
Reviews ((165KB)) in March 2006. All new HuGE reviews should follow the guidance in this document.

PLoS ONE is an international, peer-reviewed, open-access, electronic journal from the Public Library of Science (PLoS) that aims to publish scientifically rigorous papers from all disciplines within science and medicine without judging their novelty. This journal creates new potential for HuGE by promoting more complete publication of sound research, tools for research synthesis, and a medium for better interdisciplinary communication.

Recently, PloS ONE published two articles from HuGE Collaborators:

• ADRB2 Arg16Gly Polymorphism, Lung Function, and Mortality: Results from the Atherosclerosis Risk in Communities Study
  by JM Ferdinands, et al., and

• Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease
  by E Evangelou, et al.

This month, HuGENet is pleased to spotlight the ALlele FREquency Database (ALFRED) Based at the Department of Genetics at Yale University, ALFRED focuses on collecting and presenting allele frequency data from unpublished and published sources.
If you are a HuGENet™ collaborator and have a web page you would like to showcase, please email HuGE@cdc.gov. Indicate in your subject heading "HuGENet™ collaborator home page."

• View the entire list of HuGENet™ Collaborators
• Learn how to become a HuGENet™ collaborator

As of April 1, 2007, the HuGENet™ website contains 26,360 research studies indexed in the HuGE Published Literature database, referencing 2,737 genes, 919 factors (personal or environmental), and 3,264 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 58 HuGE Reviews and 466 meta-analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z.

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the  views of the Centers for Disease Control and Prevention.