ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility) Network of Excellence
ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility) Network of Excellence is to hold a HuGENet™ Workshop on the assessment of cumulative evidence on genetic associations, to be held in Venice, Italy, on 9 and 10 November.

The event will investigate cumulative evidence on genetic associations and related interactions. The workshop will follow the recent commentary by Ioannidis et al, published in Nature Genetics (see below).

The event is timed to coincide with the Italian Society of Human Genetics, also held in Venice between 8 and 11 November.
For further information, please contact:
Sabrina Bertinetti at ISI Torino
E-mail: Contact
Website: http://www.ecnis.org

This November, HuGENet UK will host a short course on how to undertake a HuGE systematic review. For more information, including a list of the faculty and topics to be covered, visit the HuGENet short course web page. Please contact:

Jane Lane
HuGENet UK Coordinating Centre
Public Health Genetics Unit
Strangeways Research Laboratory
Worts Causeway
Cambridge CB1 8RN

Tel: +44 1223 742003
Email: jane.lane@srl.cam.ac.uk

• Genomics, epidemiology, and common complex diseases: let's not throw out the baby with the bathwater! (39 KB)
  Khoury MJ, Gwinn M.
  Int J Epidemiol. 2006 Sep 19

• Genes, environment and the value of prospective cohort studies
  Teri A. Manolio, et al.
  Nature 2006; 7:812-820.

• Concordance of functional in vitro data and epidemiological associations in complex disease genetics
  Ioannidis JP et al.
  Genet Med 2006 Sep;8(9):583-593.

• What role for public health in genetics and vice versa?
  Khoury MJ, Gwinn M.
  Community Genet 2006;9(4):282.

• Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
  Salanti G, Higgins JP, White IR.
  Stat Med Sep 2006.

View all HuGENet™ Publications and learn how to submit a paper for the HuGENet™ website

Two new HuGE Reviews have been posted on the HuGENet™ website since the last issue of ‘What's New':

1. Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A Huge-GSEC Review (189KB)
   S. Raimondi et al. from the International Collaborative study on genetic susceptibility to environmental carcinogens (GSEC)
   (American Journal of Epidemiology, Advance Access).
   
   
2. Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review (213KB)
   JP Casas et al. from the British Heart Foundation Laboratories at University College London and the London School of Hygiene and Tropical Medicine
   (American Journal of Epidemiology, Advance Access).

• List of completed HuGE Reviews
• List of HuGE Review topics under development

HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic Reviews  in March 2006. All new HuGE reviews should follow the guidance in this document.

The HuGENet™ staff has compiled a list of funding opportunities for population-based research on the prevalence of human genetic variation, the association between genetic variants and human diseases, gene-gene or gene-environment interaction, or the evaluation of genetic tests for screening and prevention.  Items are pulled from the National Institutes of Health Office of Extramural Research.  Additional information and application details can be found by clicking on the respective links.  New program announcements or requests for applications will be posted in future issues of the “What's New?” as they become available.

New listings:

• Genome-wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities (U01)
  (RFA-HG-06-014)
  National Human Genome Research Institute
  Application Receipt Date(s): November 29, 2006

• Genome-wide Association Studies in the Genes and Environment Initiative – Coordinating Center (U01)
  (RFA-HG-06-032)
  National Human Genome Research Institute
  Application Receipt Date(s): November 29, 2006

• Genome-wide Association Studies in the Genes and Environment Initiative - Study Investigators (U01)
  (RFA-HG-06-033)
  National Human Genome Research Institute
  Application Receipt Date(s): November 29, 2006

This month, HuGENet™ is pleased to spotlight CRP HuGE Consortium. This network is currently working to develop collaborations between researchers examining the role of the CRP gene in the development of common diseases.

If you are a HuGENet™ collaborator and have a web page you would like to showcase, please email HuGE@cdc.gov. Indicate in your subject heading "HuGENet™ collaborator home page."

• View the entire list of HuGENet™ Collaborators
• Learn how to become a HuGENet™ Collaborator

As of October 1, 2006, the HuGENet™ website contains 23,434 research studies indexed in the HuGE Published Literature database, referencing 2,508 genes, 843 factors (personal or environmental), and 2,808 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 48 HuGE Reviews and 395meta-analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z.

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.