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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
October 9, 2008
Volume 21, No. 15

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

Frequencies of four genetic polymorphisms in the CYP1A2 gene in Turkish population
Bilgen T, et al.
Genetika 2008 Aug;44(8):1133-6

 

Neoplasms

An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients
Kawada I, et al.
J Thorac Oncol 2008 Oct;3(10):1096-103

Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk
Kaklamani VG, et al.
JAMA 2008 Oct;300(13):1523-31

Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease
Fitzgerald LM, et al.
Eur J Hum Genet 2008 Oct

Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk
Gerger A, et al.
Int J Colorectal Dis 2008 Oct

Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients
Chang H, et al.
Ann Oncol 2008 Oct

Epidermal growth factor receptor intron-1 polymorphism predicts gefitinib outcome in advanced non-small cell lung cancer
Tiseo M, et al.
J Thorac Oncol 2008 Oct;3(10):1104-11

Tobacco, antioxidant enzymes, oxidative stress, and genetic susceptibility in oral cancer
Patel BP, et al.
Am J Clin Oncol 2008 Oct;31(5):454-9

Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations
Haitian Z, et al.
Breast 2008 Oct

Specific Mutations in the {beta}-Catenin Gene (CTNNB1) Correlate with Local Recurrence in Sporadic Desmoid Tumors
Lazar AJ, et al.
Am J Pathol 2008 Oct

CHEK2 I157T and Endometrial Cancer
Konstantinova DV, et al.
DNA Cell Biol 2008 Oct

Epidermal growth factor receptor mutations in small cell lung cancer
Tatematsu A, et al.
Clin Cancer Res 2008 Oct;14(19):6092-6

CASP3 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck
Chen K, et al.
Clin Cancer Res 2008 Oct;14(19):6343-9

Endocrine, Nutritional and Metabolic Diseases

Interactions between alcohol intake and the polymorphism of rs708272 on serum high-density lipoprotein cholesterol levels in the Guangxi Hei Yi Zhuang population
Zhou Y, et al.
Alcohol 2008 Nov;42(7):583-91

Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients
Bakhtadze E, et al.
Diabetologia 2008 Oct

Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B
Eike MC, et al.
Genes Immun 2008 Oct

Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
Franks PW, et al.
Diabetologia 2008 Oct

The FTO Gene and Obesity in a Large Eastern European Population Sample: The HAPIEE Study
Hubacek JA, et al.
Obesity (Silver Spring) 2008 Oct

 

Mental Disorders

Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism
Gokturk C, et al.
Arch Womens Ment Health 2008 Oct

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal  phenotypes in schizophrenia
Bertolino A, et al.
Brain 2008 Oct

RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults
Koenen KC, et al.
Depress Anxiety 2008 Oct

Association of A/G Polymorphism in Intron 13 of the Monoamine Oxidase B Gene with Schizophrenia in a Spanish Population
Gasso P, et al.
Neuropsychobiology 2008 Oct;58(2):65-70

Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and Childhood-Onset Mood Disorders
Misener VL, et al.
Neuropsychobiology 2008 Oct;58(2):71-80

Association testing of panic disorder candidate genes using Cck-4 challenge in healthy volunteers
Maron E, et al.
Neurosci Lett 2008 Sep

Neuropeptide Y Receptor Genes Are Associated With Alcohol Dependence, Alcohol Withdrawal Phenotypes, and Cocaine Dependence
Wetherill L, et al.
Alcohol Clin Exp Res 2008 Sep

Diseases of the Nervous System and Sense Organs

Assessment of Alzheimer's disease case-control associations using family-based methods
Schjeide BM, et al.
Neurogenetics 2008 Oct

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis
Caillier SJ, et al.
J Immunol 2008 Oct;181(8):5473-80

The effect of the ApoE genotype on the association between head circumference and cognition
Kim KR, et al.
Am J Geriatr Psychiatry 2008 Oct;16(10):819-25

Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis
Benesova Y, et al.
J Neuroimmunol 2008 Oct

Absence of Association between COL1A1 Polymorphisms and High Myopia in the Japanese Population
Nakanishi H, et al.
Invest Ophthalmol Vis Sci 2008 Oct

Association of the KIAA0319 Dyslexia Susceptibility Gene With Reading Skills in the General Population
Paracchini S, et al.
Am J Psychiatry 2008 Oct

Progranulin variability has no major role in Parkinson disease genetic etiology
Nuytemans K, et al.
Neurology 2008 Oct;71(15):1147-51

Diseases of the Circulatory System

Prothrombotic polymorphisms, mutations, and their association with pediatric non-cardioembolic stroke in Asian-Indian patients
Biswas A, et al.
Ann Hematol 2008 Oct

Cerebrospinal fluid apolipoprotein e, calcium and cerebral vasospasm after subarachnoid hemorrhage
Alexander SA, et al.
Biol Res Nurs 2008 Oct;10(2):102-12

Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study
Jiang X, et al.
J Hum Hypertens 2008 Oct

Association of Arterial Stiffness With the Angiotensin-Converting Enzyme Gene Polymorphism in Healthy Individuals
Dima I, et al.
Am J Hypertens 2008 Oct

Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-
Blauwet LA, et al.
Cardiovasc Pathol 2008 Oct

Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients
Ozkok E, et al.
Med Sci Monit 2008 Oct;14(10):CR536-42

Diseases of the Respiratory System

Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
Christie JD, et al.
Crit Care Med 2008 Oct;36(10):2794-800

Effect of matrix metalloproteinase-9 -1562C/T gene polymorphism on manifestations of pulmonary tuberculosis
Lee SH, et al.
Tuberculosis (Edinb) 2008 Oct

Cysteinyl Leukotriene Receptor 1 Gene variation and Risk of Asthma in Chinese Population
Hong X, et al.
Eur Respir J 2008 Oct

Duffy Antigen/Receptor for Chemokines Gene is Associated with Asthma and IgE in Three Populations
Vergara C, et al.
Am J Respir Crit Care Med 2008 Sep

 

Diseases of the Digestive System

The association of interleukin-4 haplotypes with chronic periodontitis in a czech population
Holla LI, et al.
J Periodontol 2008 Oct;79(10):1927-33

Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: A pilot study in population of Suzhou, China
Chen WC & Nie JS
World J Gastroenterol 2008 Oct;14(37):5744-8

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Franke A, et al.
Nat Genet 2008 Oct

Effect of the Polymorphism of Tumor Necrosis Factor-alpha-308 G/A Gene Promoter on the Susceptibility to Ulcerative Colitis: A Meta-Analysis
Lu Z, et al.
Digestion 2008 Oct;78(1):44-51

Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease
Ban H, et al.
Intern Med 2008;47(19):1645-8

 

Diseases of the Musculoskeletal System and Connective Tissue

Endothelial nitric oxide synthase T-786C polymorphism in rheumatoid arthritis: association with extraarticular manifestations
Brenol CV, et al.
Clin Rheumatol 2008 Oct

Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
Glueck CJ, et al.
J Bone Joint Surg Am 2008 Oct;90(10):2220-9

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis
Harney SM, et al.
Rheumatology (Oxford) 2008 Oct

Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility
Chatzikyriakidou A, et al.
Scand J Rheumatol 2008 Sep:1-5

Congenital Anomalies

Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
Rahimov F, et al.
Nat Genet 2008 Oct

T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease
Liu C, et al.
Eur J Med Genet 2008 Sep

 

Symptoms, Signs and Ill-defined Conditions

The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans
Voisey J, et al.
Depress Anxiety 2008 Oct

Injury and Poisoning

Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy
Azria D, et al.
Clin Cancer Res 2008 Oct;14(19):6284-8

Maternal exposure to environmental tobacco smoke, GSTM1/T1 polymorphisms and oxidative stress
Park EY, et al.
Reprod Toxicol 2008 Sep

Genetic susceptibility to benzene toxicity in humans
Garte S, et al.
J Toxicol Environ Health A 2008;71(22):1482-9

 

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Page last reviewed: October 9, 2008 (archived document)
Content Source: National Office of Public Health Genomics