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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
September 18, 2008
Volume 21, No. 12

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa
Veeramah KR, et al.
Pharmacogenet Genomics 2008 Oct;18(10):877-86

Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
Manco L, et al.
Am J Hum Biol 2008 Sep

 

Infectious and Parasitic Diseases

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers
Hardie RA, et al.
AIDS 2008 Oct;22(15):2038-42

The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis
Gupta SK, et al.
AIDS 2008 Oct;22(15):1919-27

The Association of C (-260)-->T Polymorphism in CD14 Promoter and Chlamydia pneumoniae Infection in Ischemic Stroke Patients
Lin TM, et al.
Am J Clin Pathol 2008 Oct;130(4):595-601

Lack of Association of the HbE Variant with Protection from Cerebral Malaria in Thailand
Naka I, et al.
Biochem Genet 2008 Sep

Genetic factors that confer sensitivity to HAART in HIV-infected subjects: implication of a benefit of an earlier initiation of HAART
Nakajima T & Kimura A
Pharmacogenomics 2008 Sep;9(9):1347-51

Regulatory Polymorphisms in the Interleukin-18 Promoter Are Associated with Hepatitis C Virus Clearance
An P, et al.
J Infect Dis 2008 Sep

Polymorphic Variability in the Interleukin (IL)-1beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1beta Production
Ouma C, et al.
J Infect Dis 2008 Sep

 

Neoplasms

The E-cadherin (CDH1) -160 C/A polymorphism and prostate cancer risk: a meta-analysis
Qiu LX, et al.
Eur J Hum Genet 2008 Sep

Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma
Gu F, et al.
Melanoma Res 2008 Oct;18(5):330-5

Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China
Zhang Y, et al.
BMC Cancer 2008 Sep;8(1):256

Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women
Chan KY, et al.
J Med Genet 2008 Sep

ERCC6/CSB gene polymorphisms and lung cancer risk
Ma H, et al.
Cancer Lett 2008 Sep

Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes
Schneider BP, et al.
Breast Cancer Res Treat 2008 Sep

Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure, and  esophageal adenocarcinoma risk
Zhai R, et al.
Carcinogenesis 2008 Sep

The effects of common genetic variants in oncogenes on ovarian cancer survival
Quaye L, et al.
Clin Cancer Res 2008 Sep;14(18):5833-9

Association of prostate cancer risk variants with clinicopathologic characteristics of the disease
Xu J, et al.
Clin Cancer Res 2008 Sep;14(18):5819-24

Novel breast cancer risk alleles and endometrial cancer risk
McGrath M, et al.
Int J Cancer 2008 Sep

Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia
Weinberg JB, et al.
Leukemia 2008 Sep

 

Endocrine, Nutritional and Metabolic Diseases

Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients
Enya M, et al.
Hum Mutat 2008 Sep

Novel genetic variant in FTO influences insulin levels and insulin resistance in  severely obese children and adolescents
Jacobsson JA, et al.
Int J Obes (Lond) 2008 Sep

FTO Polymorphisms Are Associated With Obesity but Not Diabetes Risk in Postmenopausal Women
Song Y, et al.
Obesity (Silver Spring) 2008 Sep

The APOA5 Trp19 allele is associated with metabolic syndrome via its association  with plasma triglycerides
Dallongeville J, et al.
BMC Med Genet 2008 Sep;9(1):84

 

Diseases of the Blood & Blood-Forming Organ Disorders

Effects of CYP2C9 and VKORC1 on INR variations and dose requirements during initial phase of anticoagulant therapy
Spreafico M, et al.
Pharmacogenomics 2008 Sep;9(9):1237-50

 

Mental Disorders

The Alpha 2A-Adrenergic Receptor Gene Polymorphism Modifies Antidepressant Responses to Milnacipran
Wakeno M, et al.
J Clin Psychopharmacol 2008 Oct;28(5):518-24

A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder
Benedetti F, et al.
Neurosci Lett 2008 Sep

Association Between the G1001C Polymorphism in the GRIN1 Gene Promoter and Schizophrenia in the Iranian Population
Galehdari H
J Mol Neurosci 2008 Sep

Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
Kwon JS, et al.
Eur Neuropsychopharmacol 2008 Sep

Delinquent peer group formation: evidence of a gene x environment correlation
Beaver KM, et al.
J Genet Psychol 2008 Sep;169(3):227-44

Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population
Kim YR, et al.
Eur Neuropsychopharmacol 2008 Sep

A mu opioid receptor gene polymorphism (A118G) and naltrexone treatment response  in adherent Korean alcohol-dependent patients
Kim SG, et al.
Psychopharmacology (Berl) 2008 Sep

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking
Sherva R, et al.
Addiction 2008 Sep;103(9):1544-52

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population
Numata S, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: Analysis of suicidality in major psychosis
Luca VD, et al.
J Psychiatr Res 2008 Sep

 

Diseases of the Nervous System and Sense Organs

Evidence for an association between KIBRA and late-onset Alzheimer's disease
Corneveaux JJ, et al.
Neurobiol Aging 2008 Sep

Genetic variation of Omi/HtrA2 and Parkinson's disease
Ross OA, et al.
Parkinsonism Relat Disord 2008 Sep

The PSP-associated MAPT H1 subhaplotype in Guadeloupean atypical Parkinsonism
Camuzat A, et al.
Mov Disord 2008 Sep

Association of common variants in the Joubert syndrome gene (AHI1) with autism
Alvarez Retuerto AI, et al.
Hum Mol Genet 2008 Sep

Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease
Hashimoto R, et al.
Genes Brain Behav 2008 Sep

Interaction of the delta-Aminolevulinic Acid Dehydratase Polymorphism and Lead Burden on Cognitive Function: The VA Normative Aging Study
Rajan P, et al.
J Occup Environ Med 2008 Sep;50(9):1053-61

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression
Kwan P, et al.
Pharmacogenet Genomics 2008 Sep

SNPs in Neurotrophin System Genes and Alzheimer's Disease in an Italian Population
Cozza A, et al.
J Alzheimers Dis 2008 Sep;15(1):61-70

COMPLEMENT FACTOR H VARIANT INCREASES THE RISK FOR EARLY AGE-RELATED MACULAR DEGENERATION
Lin JM, et al.
Retina 2008 Sep

 

Diseases of the Circulatory System

Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in beta-Blocker Users
Bijl M, et al.
Clin Pharmacol Ther 2008 Sep

A Haplotype of the CYP4F2 Gene is Associated With Cerebral Infarction in Japanese Men
Fu Z, et al.
Am J Hypertens 2008 Sep

Intercellular adhesion molecule-1 gene K469E polymorphism and ischemic stroke: a  case-control study in a Chinese population
Li XX, et al.
Mol Biol Rep 2008 Sep

The Association of ADH and ALDH Gene Variants With Alcohol Drinking Habits and Cardiovascular Disease Risk Factors
Husemoen LL, et al.
Alcohol Clin Exp Res 2008 Sep

Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke
Guldiken B, et al.
Mol Biol Rep 2008 Sep

Angiotensinogen M235T Associated With Mitral Valve Prolapse in Young Han Chinese  Male
Lung FW, et al.
Am J Med Sci 2008 Sep;336(3):237-40

Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: Results from a randomized trial
Kearon C, et al.
Blood 2008 Sep

CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
Geisler T, et al.
Pharmacogenomics 2008 Sep;9(9):1251-9

The Risk of Coronary Artery Disease Associated with Cigarette Smoking and Hypercholesterolemia Is Additionally Increased by the Presence of the AT ( 1 ) R  Gene 1166C Allele
Niemiec P, et al.
Biochem Genet 2008 Sep

 

Diseases of the Respiratory System

Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children
Plunkett A, et al.
Intensive Care Med 2008 Sep

Lung function in relation to 2-thiothiazolidine-4-carboxylic Acid and genetic effect modification among rubber workers in sweden
Jonsson LS, et al.
J Occup Environ Med 2008 Sep;50(9):1006-12

CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease
Kim WJ, et al.
Respir Med 2008 Sep

Association of cytokine gene polymorphisms with bronchial asthma in macedonians
Trajkov D, et al.
Iran J Allergy Asthma Immunol 2008 Sep;7(3):143-56

 

Diseases of the Digestive System

CARD15 gene polymorphisms in Serbian patients with Crohn's disease: genotype-phenotype analysis
Protic MB, et al.
Eur J Gastroenterol Hepatol 2008 Oct;20(10):978-84

A new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: -330T>G polymorphism of the interleukin-2 gene
Marcos M, et al.
Eur J Gastroenterol Hepatol 2008 Sep;20(9):855-9

Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
Sookoian S, et al.
Cytokine 2008 Sep

Enamel Formation Genes Are Associated with High Caries Experience in Turkish Children
Patir A, et al.
Caries Res 2008 Sep;42(5):394-400


Diseases of the Genitourinary System

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
Kopp JB, et al.
Nat Genet 2008 Sep

Influence of recipient and donor IL-10, TNFA and INFG genotypes on the incidence  of acute renal allograft rejection
Azarpira N, et al.
Mol Biol Rep 2008 Sep

Association of C-509T and T869C Polymorphisms of Transforming Growth Factor-beta1 Gene With Chronic Allograft Nephropathy and Graft Survival in Korean Renal Transplant Recipients
Cho JH, et al.
Transplant Proc 2008 Sep;40(7):2355-60

 

Diseases of the Skin and Subcutaneous Tissue

Association of Skin Barrier Genes within the PSORS4 Locus Is Enriched in Singaporean Chinese with Early-Onset Psoriasis
Chen H, et al.
J Invest Dermatol 2008 Sep

 

Diseases of the Musculoskeletal System and Connective Tissue

Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Raychaudhuri S, et al.
Nat Genet 2008 Sep

Lack of Association Between the Promoter Polymorphism of the MTNR1A Gene and Adolescent Idiopathic Scoliosis
Qiu XS, et al.
Spine 2008 Sep;33(20):2204-7

Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese  population
Suzuki A, et al.
Nat Genet 2008 Sep

Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in han chinese
Wang H, et al.
Spine 2008 Sep;33(20):2199-203

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes
Rodriguez-Lopez J, et al.
Osteoarthritis Cartilage 2008 Sep

Genetic Variation in C-Reactive Protein (CRP) Gene May Be Associated with Risk of Systemic Lupus Erythematosus and CRP Concentrations
Shih PB, et al.
J Rheumatol 2008 Sep

Functional Polymorphisms of Folate-Metabolizing Enzymes in Relation to Homocysteine Concentrations in Systemic Lupus Erythematosus
Summers CM, et al.
J Rheumatol 2008 Sep

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures
Tranah GJ, et al.
Calcif Tissue Int 2008 Sep

Genetic and Expression Analysis of CASP7 Gene in a European Caucasian Population  with Rheumatoid Arthritis
Teixeira VH, et al.
J Rheumatol 2008 Sep

 

Congenital Anomalies

TGFA/TAQ I Polymorphism in Nonsyndromic Cleft Lip and Palate Patients from Rio Grande Do Sul, Brazil
Ehlers Bertoja A, et al.
Cleft Palate Craniofac J 2008 Sep;45(5):539-44

 

Certain Conditions Originating in the Perinatal Period

Genetic Contributions to the Development of Retinopathy of Prematurity
Mohamed S, et al.
Pediatr Res 2008 Sep

Association of polymorphisms in the human surfactant protein-D (SFTPD) gene and postnatal pulmonary adaptation in the preterm infant
Hilgendorff A, et al.
Acta Paediatr 2008 Sep

 

Injury and Poisoning

Polymorphisms in Phase I and Phase II Metabolism Genes and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population
Sun P, et al.
Carcinogenesis 2008 Sep

 

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Page last reviewed: September 18, 2008 (archived document)
Content Source: National Office of Public Health Genomics