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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
October 2, 2008
Volume 21, No. 14

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

HUMTH01, HUMVWA31A, HUMCSF1PO and HUMTPOX polymorphisms in Amerindian populations living in the Beni Department of Bolivia
Corella A, et al.
Ann Hum Biol 2008 Sep-2008 Oct;35(5):556-64

 

Infectious and Parasitic Diseases

Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma
Puthothu B, et al.
Pediatr Allergy Immunol 2008 Sep

Human Leukocyte Antigen (HLA)-B, -DRB1 and -DQB1 Allotypes Associated with Disease and Protection in Trachoma Endemic Villages
Abbas M, et al.
Invest Ophthalmol Vis Sci 2008 Sep

Effects of CYP2C19 and MDR1 genotype on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin
Oh JH, et al.
J Gastroenterol Hepatol 2008 Sep

 

Neoplasms

Association of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 Genetic Polymorphisms With Outcome in a Trial of Paclitaxel Compared With Paclitaxel Plus Bevacizumab in Advanced Breast Cancer: ECOG 2100
Schneider BP, et al.
J Clin Oncol 2008 Oct;26(28):4672-8

Phase II Study of Imatinib in Patients With Recurrent Gliomas of Various Histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
Raymond E, et al.
J Clin Oncol 2008 Oct;26(28):4659-65

Association of DRB1 and DQB1 HLA class II polymorphisms in high-grade and neoplastic cervical lesions of women from Argentina
Eiguchi K, et al.
J Low Genit Tract Dis 2008 Oct;12(4):262-8

Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population
Kasahara M, et al.
J Exp Clin Cancer Res 2008 Sep;27(1):49

CASP8 D302H and meningioma risk: An analysis of five case-control series
Bethke L, et al.
Cancer Lett 2008 Sep

The -786T>C promoter polymorphism of the NOS3 gene is associated with prostate cancer progression
Marangoni K, et al.
BMC Cancer 2008 Sep;8(1):273

Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis
Wang M, et al.
Clin Exp Med 2008 Sep

Glutathione-S-Transferase and Microsomal Epoxide Hydrolase Polymorphism and Viral-Related Hepatocellular Carcinoma Risk in India
Kiran M, et al.
DNA Cell Biol 2008 Sep

Vitamin D receptor polymorphisms and the risk of cutaneous melanoma: a systematic review and meta-analysis
Mocellin S & Nitti D
Cancer 2008 Sep

Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population
Chen D, et al.
Pharmacogenet Genomics 2008 Sep

Double-strand break DNA repair genotype predictive of later mortality and cancer  incidence in a cohort of non-smokers
Neasham D, et al.
DNA Repair (Amst) 2008 Sep

CCND1 G870A polymorphism contributes to breast cancer susceptibility: a meta-analysis
Lu C, et al.
Breast Cancer Res Treat 2008 Sep

BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy
Ottini L, et al.
Breast Cancer Res Treat 2008 Sep

Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers
Eisen A, et al.
J Natl Cancer Inst 2008 Sep

MDR1 Single Nucleotide Polymorphism G2677T/A and Haplotype Are Correlated with Response to Docetaxel-Cisplatin Chemotherapy in Patients with Non-Small-Cell Lung Cancer
Pan JH, et al.
Respiration 2008 Sep

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta
Kauwe JS, et al.
Neurogenetics 2008 Sep

Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia
Hawwa AF, et al.
Br J Clin Pharmacol 2008 Sep

A haplotype variation affecting the mitochondrial transportation of hMYH protein  could be a risk factor for colorectal cancer in Chinese
Chen H, et al.
BMC Cancer 2008 Sep;8(1):269

The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor
Ashton KA, et al.
BMC Cancer 2008 Sep;8(1):272

HLA-class II alleles in Egyptian patients with hepatocellular carcinoma
El-Chennawi FA, et al.
Immunol Invest 2008;37(7):661-74

 

Endocrine, Nutritional and Metabolic Diseases

Does the SLC40A1 gene modify HFE-related haemochromatosis phenotypes?
Altes A, et al.
Ann Hematol 2008 Sep

The Fatty Acid Amide Hydrolase (FAAH) Pro129Thr Polymorphism is not Associated with Severe Obesity in Greek Subjects
Papazoglou D, et al.
Horm Metab Res 2008 Sep

Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome  in the Greek population
Rouskas K, et al.
Int J Obes (Lond) 2008 Sep

Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus
Plengvidhya N, et al.
Clin Endocrinol (Oxf) 2008 Sep

Genetic variation may influence obesity only under conditions of diet: Analysis of three candidate genes
Aberle J, et al.
Mol Genet Metab 2008 Sep

Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome
Filus A, et al.
Aging Male 2008 Sep;11(3):134-9

A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study
Donnelly LA, et al.
Pharmacogenet Genomics 2008 Sep

Modulation of Insulin Concentrations and Metabolic Parameters in Obese Patients by -55CT Polymorphism of the UCP3 Gene Secondary to Two Hypocaloric Diets
Luis DA, et al.
Horm Metab Res 2008 Sep

Relationships between gene polymorphisms of folate-related proteins and vitamins  and metabolites in pregnant women and neonates
Lopreato FR, et al.
Clin Chim Acta 2008 Sep

Association of SIRT1 gene variation with visceral obesity
Peeters AV, et al.
Hum Genet 2008 Sep

Effect of TCF7L2 polymorphism on the genetic susceptibility to obesity in the Tunisian population
Bouhaha R, et al.
Pathol Biol (Paris) 2008 Sep

Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1alpha gene
Goyenechea E, et al.
Diabetes Res Clin Pract 2008 Sep

 

Mental Disorders

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
O'Donovan MC, et al.
Mol Psychiatry 2008 Sep

SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population
Wang Y, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2008 Sep

GABRG1 and GABRA2 as Independent Predictors for Alcoholism in Two Populations
Enoch MA, et al.
Neuropsychopharmacology 2008 Sep

A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder
Pickard BS, et al.
Proc Natl Acad Sci U S A 2008 Sep

Interaction between SERTPR and stressful life events on response to antidepressant treatment
Mandelli L, et al.
Eur Neuropsychopharmacol 2008 Sep

Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample
Saetre P, et al.
Schizophr Res 2008 Sep

SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families
Kollins SH, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder
Meltzer HY, et al.
Schizophr Res 2008 Sep

 

Diseases of the Nervous System and Sense Organs

Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Miyagawa T, et al.
Nat Genet 2008 Sep

NPHS2 variation in focal and segmental glomerulosclerosis
Tonna SJ, et al.
BMC Nephrol 2008 Sep;9(1):13

No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population
Lakhan R, et al.
Epilepsy Behav 2008 Sep

DNA variants in coding region of EFHC1: SNPs do not associate with juvenile myoclonic epilepsy
Bai D, et al.
Epilepsia 2008 Sep

 

Diseases of the Circulatory System

Two common haplotypes of the glucocorticoid receptor gene are associated with increased susceptibility to cardiovascular disease in men with familial hypercholesterolemia
Koeijvoets KC, et al.
J Clin Endocrinol Metab 2008 Sep

Should Plasma Homocysteine Be Used as a Biomarker of Venous Thromboembolism? A Case--Control Study
Ducros V, et al.
Clin Appl Thromb Hemost 2008 Sep

Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: Interaction with cigarette smoking
Hou L, et al.
Thromb Res 2008 Sep

Transforming growth factor beta1 T29C gene polymorphism and hypertension: Relationship with cardiovascular and renal damage
Argano C, et al.
Blood Press 2008 Sep:1-7

 

Diseases of the Respiratory System

Functional polymorphism of the promoter region of the prostacyclin synthase gene  and severity of RSV infection in hospitalized children
Hashimoto K, et al.
J Med Virol 2008 Nov;80(11):2015-22

Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses
Hu G, et al.
Respirology 2008 Nov;13(6):837-50

Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: A cross-sectional population-based study in Korea
Park HW, et al.
Respir Med 2008 Sep

Association of polymorphisms in CASP10 and CASP8 with FEV/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics
Smith AK, et al.
Clin Exp Allergy 2008 Sep

A new PTGDR promoter polymorphism in a population of children with asthma
Sanz C, et al.
Pediatr Allergy Immunol 2008 Sep

 

Diseases of the Digestive System

Cytokine genotypes in acute pancreatitis: association with etiology, severity, and cytokine levels in blood
de-Madaria E, et al.
Pancreas 2008 Oct;37(3):295-301

Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population
Ostergaard M, et al.
Scand J Gastroenterol 2008 Sep:1-9

Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy
Achyut BR, et al.
Mol Cell Biochem 2008 Sep

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort
Weersma RK, et al.
Gut 2008 Sep

The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis
Calva-Cerqueira D, et al.
Clin Genet 2008 Sep

Mannose-binding lectin gene polymorphisms in relation to periodontitis
Louropoulou A, et al.
J Clin Periodontol 2008 Sep


Diseases of the Genitourinary System

A common RET variant is associated with reduced newborn kidney size and function
Zhang Z, et al.
J Am Soc Nephrol 2008 Oct;19(10):2027-34

Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation
Quteineh L, et al.
Transplantation 2008 Sep;86(6):779-83

Modifier Effect of the Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase Gene in Autosomal-Dominant Polycystic Kidney Disease
Stefanakis N, et al.
Nephron Clin Pract 2008 Sep;110(2):c101-c106

Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population
Makni K, et al.
Ann Hum Biol 2008 Sep-2008 Oct;35(5):490-8

 

Diseases of the Skin and Subcutaneous Tissue

Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients
Namian AM, et al.
Arch Dermatol Res 2008 Sep

 

Diseases of the Musculoskeletal System and Connective Tissue

Homozygosity for DNASE2 single-nucleotide polymorphisms in the 5' regulatory region is associated with rheumatoid arthritis
Rossol M, et al.
Ann Rheum Dis 2008 Sep

Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty
Gordon A, et al.
Arthritis Rheum 2008 Sep;58(10):3157-65

A Functional Ser413/Ser413 PAI-2 Polymorphism Is Associated With Susceptibility and Damage Index Score in Systemic Lupus Erythematosus
Palafox-Sanchez CA, et al.
Clin Appl Thromb Hemost 2008 Sep

Lack of association between Tenascin-C gene and spondyloarthritis
Zinovieva E, et al.
Rheumatology (Oxford) 2008 Sep

 

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Page last reviewed: October 2, 2008 (archived document)
Content Source: National Office of Public Health Genomics