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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
May 15, 2008
Volume 20, No. 20

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

Association of RANTES -403 G/A, -28 C/G and In1.1 T/C polymorphism with HIV-1 transmission and progression among North Indians
Rathore A, et al.
J Med Virol 2008 Jul;80(7):1133-41

HLA-Bw4 Homozygosity Is Associated with an Impaired CD4 T Cell Recovery after Initiation of Antiretroviral Therapy
Rauch A, et al.
Clin Infect Dis 2008 May

Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus
Xu YY, et al.
Int J Biol Sci 2008;4(2):111-5

 

Neoplasms

Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence
Hubner RA, et al.
Int J Cancer 2008 May

Association of p53 polymorphisms and colorectal cancer: Modulation of risk and progression
Mammano E, et al.
Eur J Surg Oncol 2008 May

Promoter-hypermethylation associated defective expression of E-cadherin in primary non-small cell lung cancer
Wang G, et al.
Lung Cancer 2008 May

MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia
Gryshchenko I, et al.
J Clin Oncol 2008 May;26(14):2252-7

Polymorphisms in the Aurora-A Gene Is Not Associated with Lung Cancer in the Turkish Population
Dogan I, et al.
DNA Cell Biol 2008 May

No Association between the SRD5A2 Gene A49T Missense Variant and Prostate Cancer  Risk: Lessons Learned
Pearce CL, et al.
Hum Mol Genet 2008 May

REV1 genetic variants associated with the risk of cervical carcinoma
He X, et al.
Eur J Epidemiol 2008 May

Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
Jazdzewski K, et al.
Proc Natl Acad Sci U S A 2008 May

CYP1A1, GSTM1, and GSTT1 Polymorphisms, Smoking, and Lung Cancer Risk in a Pooled Analysis among Asian Populations
Lee KM, et al.
Cancer Epidemiol Biomarkers Prev 2008 May

Common Polymorphisms in the MDM2 and TP53 Genes and the Relationship between TP53 Mutations and Patient Outcomes in Glioblastomas
Zawlik I, et al.
Brain Pathol 2008 May

Intercellular adhesion molecule-1 genetic markers (+241G/A and +469A/G) in Iranian women with breast cancer
Arandi N, et al.
Cancer Genet Cytogenet 2008 May;183(1):9-13

CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians
Soya SS, et al.
Pharmacogenomics 2008 May;9(5):551-60

Manganese Superoxide Dismutase Gene Coding Region Polymorphisms Lack Clinical Incidence in General Population
Martin RC, et al.
DNA Cell Biol 2008 May

FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients
Paiva M, et al.
Cancer Genet Cytogenet 2008 May;183(1):35-40

Common germline MDR1/ABCB1 functional polymorphisms and haplotypes modify susceptibility to colorectal cancers with high microsatellite instability
Potocnik U, et al.
Cancer Genet Cytogenet 2008 May;183(1):28-34

Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients
Sreeja L, et al.
J Exp Ther Oncol 2008;7(1):73-85

Association of IL-6 gene polymorphisms with cachexia susceptibility and survival  time of patients with pancreatic cancer
Zhang D, et al.
Ann Clin Lab Sci 2008 Spring;38(2):113-9

 

Endocrine, Nutritional and Metabolic Diseases

Interleukin-1 Beta gene polymorphism and traditional constitution in obese women
Lee JH, et al.
Int J Neurosci 2008 Jun;118(6):793-805

Association of Genetic Variation in ENPP1 With Obesity-related Phenotypes
Jenkinson CP, et al.
Obesity (Silver Spring) 2008 May

Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes
Porksen S, et al.
Pediatr Diabetes 2008 May

Association between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects with Type 1 Diabetes
Gallego PH, et al.
Diabetes Care 2008 May

A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians
Vimaleswaran KS, et al.
Hum Genet 2008 May

Association of the ins/del polymorphisms of uncoupling protein 2 (UCP2) with BMI  in a Korean population
Lee YH, et al.
Biochem Biophys Res Commun 2008 May

Implication of Genetic Variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2 and FTO in Type 2 Diabetes and Obesity in 6719 Asians
Ng MC, et al.
Diabetes 2008 May

Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans
Kim JT, et al.
Clin Endocrinol (Oxf) 2008 May

Long term exercise training decreases IL-6 serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in interleukin-6 gene
Oberbach A, et al.
Eur J Endocrinol 2008 May

The PPARgamma2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy
Jorsal A, et al.
Mol Genet Metab 2008 May

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
Cauchi S, et al.
PLoS ONE 2008;3(5):e2031

 

Diseases of the Blood & Blood-Forming Organ Disorders

Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
Limdi NA, et al.
Pharmacogenomics 2008 May;9(5):511-26

Variation in the insulin-like growth factor-1 gene is associated with lymphocyte  subset counts in neonates. The Generation R Study
Duijts L, et al.
Clin Endocrinol (Oxf) 2008 May

 

Mental Disorders

Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin
Schirmbeck F, et al.
J Autism Dev Disord 2008 May

Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample
Soronen P, et al.
Biol Psychiatry 2008 May

Support for Neuregulin 1 as a Susceptibility Gene for Bipolar Disorder and Schizophrenia
Georgieva L, et al.
Biol Psychiatry 2008 May

Elucidating the Relationship between DISC1, NDEL1, and NDE1 and the Risk for Schizophrenia: Evidence of Epistasis and Competitive Binding
Burdick KE, et al.
Hum Mol Genet 2008 May

The estrogen hypothesis of Schizophrenia implicates glucose metabolism: Association study in three independent samples
Olsen L, et al.
BMC Med Genet 2008 May;9(1):39

 

Diseases of the Nervous System and Sense Organs

The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia
Reif A, et al.
Eur J Neurol 2008 Jun;15(6):637-9

Age-dependent cognitive changes in carriers of the fragile X syndrome
Cornish KM, et al.
Cortex 2008 Jun;44(6):628-36

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral  sclerosis
Vucic S, et al.
Brain 2008 May

Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down Syndrome
Prasher VP, et al.
Int J Geriatr Psychiatry 2008 May

Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients
de Carvalho Aguiar P, et al.
Mov Disord 2008 May

Impact of CYP2C19 polymorphisms on the efficacy of clobazam therapy
Seo T, et al.
Pharmacogenomics 2008 May;9(5):527-37

Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration
Canter JA, et al.
PLoS ONE 2008;3(5):e2091

 

Diseases of the Circulatory System

Association between HMOX-1 genotype and cardiac function during exercise
He Z, et al.
Appl Physiol Nutr Metab 2008 Jun;33(3):450-60

Significance of angiotensinogen gene haplotypes and genotypes combinations in hypertension
Nejatizadeh A, et al.
J Hypertens 2008 Jun;26(6):1094-101

The Relationship Between the Plasma Concentration of Irbesartan and the Antihypertensive Response Is Disclosed by an Angiotensin II Type 1 Receptor Polymorphism: Results From the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs.
Kurland L, et al.
Am J Hypertens 2008 May

The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis of 13,949 individuals
Vimaleswaran KS, et al.
J Appl Physiol 2008 May

Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on  the Risk of a First Venous Thrombosis
Meltzer ME, et al.
PLoS Med 2008 May;5(5):e97

Cigarette smoking, carrier state of A or G allele of 46A>G and 79C>G polymorphisms of beta2-adrenergic receptor gene, and the risk of coronary artery  disease
Zak I, et al.
Kardiol Pol 2008 Apr;66(4):380-6

 

Diseases of the Digestive System

IL23R haplotypes provide a large population attributable risk for Crohn's disease
Taylor KD, et al.
Inflamm Bowel Dis 2008 May

Hemochromatosis Gene Status as a Risk Factor for Barrett's Esophagus
Corley DA, et al.
Dig Dis Sci 2008 May

(GT)(n) Dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course
Hausmann M, et al.
Clin Exp Immunol 2008 May

Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis
Sazci A, et al.
Dig Dis Sci 2008 May

 

Diseases of the Genitourinary System

Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism
Ozaki KS, et al.
Clin Transplant 2008 May

PAI-1 donor polymorphism influences long-term kidney graft survival
Jean-Philippe R, et al.
Nephrol Dial Transplant 2008 May

Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome
Riveira-Munoz E, et al.
Nephrol Dial Transplant 2008 May

 

Diseases of the Musculoskeletal System and Connective Tissue

PTPN22, PADI-4 and CTLA-4 genetic polymorphisms and risk of rheumatoid arthritis  in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
Costenbader KH, et al.
Arthritis Res Ther 2008 May;10(3):R52

The Asn19Lys Substitution in the Osteoclast Inhibitory Lectin (OCIL) Gene is Associated with a Reduction of Bone Mineral Density in Postmenopausal Women
Pineda B, et al.
Calcif Tissue Int 2008 May

Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population
Tsezou A, et al.
J Orthop Res 2008 May

Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms
Macdonald HM, et al.
Am J Clin Nutr 2008 May;87(5):1513-20

Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies
Karppinen J, et al.
Spine 2008 May;33(11):1236-41

A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation
Hirose Y, et al.
Am J Hum Genet 2008 May;82(5):1122-9

Single nucleotide polymorphisms in new candidate genes are associated with bone mineral density and fracture risk
Lazary A, et al.
Eur J Endocrinol 2008 May

Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis
Shi D, et al.
Arthritis Res Ther 2008 May;10(3):R54

Association of a single nucleotide polymorphism in the insulin-like growth factor-1 receptor gene with spinal disc degeneration in postmenopausal Japanese women
Urano T, et al.
Spine 2008 May;33(11):1256-61

Interleukin-1 receptor antagonist gene polymorphisms are associated with disease  severity in Black South Africans with rheumatoid arthritis
Lubbe S, et al.
Joint Bone Spine 2008 May

 

Congenital Anomalies

Investigation of MYH14 as a candidate gene in cleft lip with or without cleft palate
Martinelli M, et al.
Eur J Oral Sci 2008 Jun;116(3):287-90

 

Certain Conditions Originating in the Perinatal Period

Impact of maternal endothelial nitric oxide synthase gene polymorphisms on blood  pressure, protein excretion and fetal outcome in pregnancy
Hocher B, et al.
J Hum Hypertens 2008 May

 

Symptoms, Signs and Ill-defined Conditions

Association of the ACTN3 R577X polymorphism with power athlete status in Russians
Druzhevskaya AM, et al.
Eur J Appl Physiol 2008 May

 

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Page last reviewed: May 15, 2008 (archived document)
Content Source: National Office of Public Health Genomics