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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 20, 2008
Volume 20, No. 12

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Neoplasms

Genetic variants of interleukin-1RN and interleukin-1beta genes and risk of cervical cancer
Singh H, et al.
BJOG 2008 Apr;115(5):633-8

Heat Shock Protein A1B 1267 Polymorphism Is Highly Associated With Risk and Prognosis of Hepatocellular Carcinoma: A Case-Control Study
Jeng JE, et al.
Medicine (Baltimore) 2008 Mar;87(2):87-98

XRCC1 Genetic Polymorphisms and Bladder Cancer Susceptibility: A Meta-analysis
Wang C, et al.
Urology 2008 Mar

The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain
Fernandez-Rubio A, et al.
Lung Cancer 2008 Mar

The -149C>T SNP within the DeltaDNMT3B gene, is not associated with early disease onset in hereditary non-polyposis colorectal cancer
Reeves SG, et al.
Cancer Lett 2008 Mar

New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer
Guzman VB, et al.
Hum Mol Genet 2008 Mar

Overall and Relapse-Free Survival in Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma Are Associated with Genotypes of T393C Polymorphism of the GNAS1 Gene
Lehnerdt GF, et al.
Clin Cancer Res 2008 Mar;14(6):1753-8

A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
He C, et al.
Breast Cancer Res Treat 2008 Mar

Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status
Xu Y, et al.
Int J Cancer 2008 Mar

Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis
Mao R, et al.
J Hum Genet 2008 Mar

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer
Siltanen S, et al.
Eur J Hum Genet 2008 Mar

CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
Jenab M, et al.
Eur J Cancer 2008 Mar

Correlation of CDA, ERCC1, and XPD Polymorphisms with Response and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients
Tibaldi C, et al.
Clin Cancer Res 2008 Mar;14(6):1797-803

HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes
Taylor GM, et al.
Br J Cancer 2008 Mar

Cisplatin plus weekly CPT-11/docetaxel in advanced esophagogastric cancer: a phase I study with pharmacogenetic assessment of XPD, XRCC3 and UGT1A1 polymorphisms
Font A, et al.
Cancer Chemother Pharmacol 2008 Mar

Association of a Common AKAP9 Variant With Breast Cancer Risk: A Collaborative Analysis
Frank B, et al.
J Natl Cancer Inst 2008 Mar

Prognostic significance of foetal-like tyrosine kinase 3 mutation in Egyptian children with acute leukaemia
Al-Tonbary Y, et al.
Int J Lab Hematol 2008 Mar

No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer
Bougatef K, et al.
Pathol Biol (Paris) 2008 Mar

Correlation of transforming growth factor beta-1 gene polymorphisms C-509T and T869C and the risk of gastric cancer in China
Li T, et al.
J Gastroenterol Hepatol 2008 Mar

Correlation of -31G/C Polymorphisms of Survivin Promoter to Tumorigenesis of Gastric Carcinoma
Cheng ZJ, et al.
Ai Zheng 2008 Mar;27(3):258-63

Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia
Liu CY, et al.
Carcinogenesis 2008 Mar

 

Endocrine, Nutritional and Metabolic Diseases

The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus
Schouwenberg BJ, et al.
Pharmacogenet Genomics 2008 Apr;18(4):369-72

Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study
Donnelly LA, et al.
Pharmacogenet Genomics 2008 Apr;18(4):279-87

The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II
Qu HQ, et al.
Genes Immun 2008 Mar

Mutations in the beta1 adrenergic receptor gene and massive obesity in Japanese
Ohshiro Y, et al.
Diabetes Res Clin Pract 2008 Mar

Modulation of Adipocytokines Response and Weight Loss Secondary to a Hypocaloric  Diet in Obese Patients by -55CT Polymorphism of UCP3 Gene
Luis DA, et al.
Horm Metab Res 2008 Mar;40(3):214-8

Is Fetuin-A/alpha2-Heremans-Schmid Glycoprotein Associated with the Metabolic Syndrome in Patients with Chronic Kidney Disease?
Axelsson J, et al.
Am J Nephrol 2008 Mar;28(4):669-76

Exploring the Developmental Overnutrition Hypothesis Using Parental-Offspring Associations and FTO as an Instrumental Variable
Lawlor DA, et al.
PLoS Med 2008 Mar;5(3):e33

beta(3)-Adrenergic receptor polymorphism and metabolic syndrome in postmenopausal women
Dunajska K, et al.
Gynecol Endocrinol 2008 Mar;24(3):133-8

Association of morbid obesity with FTO and INSIG2 allelic variants
Chu X, et al.
Arch Surg 2008 Mar;143(3):235-40;discussion 241

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in  a non-Caucasian multi-ethnic sample
Al-Attar SA, et al.
Cardiovasc Diabetol 2008 Mar;7(1):5

CYP1A1 gene polymorphism and polycystic ovary syndrome
Esinler I, et al.
Reprod Biomed Online 2008 Mar;16(3):356-60

Sequence alterations in the YBX2 gene are associated with male factor infertility
Hammoud S, et al.
Fertil Steril 2008 Mar

Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
Grant SF, et al.
PLoS ONE 2008;3(3):e1746

 

Mental Disorders

Comprehensive analysis of polymorphisms throughout GAD1 gene: a family-based association study in schizophrenia
Du J, et al.
J Neural Transm 2008 Mar

Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression
Pezawas L, et al.
Mol Psychiatry 2008 Mar

A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers
Huang W, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Association of MAO-A Variant with Complicated Grief in Major Depression
Kersting A, et al.
Neuropsychobiology 2008 Mar;56(4):191-6

Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fracture
Lenze EJ, et al.
J Affect Disord 2008 Mar

G72 and Its Association With Major Depression and Neuroticism in Large Population-Based Groups From Germany
Rietschel M, et al.
Am J Psychiatry 2008 Mar

A Haplotype of the DRD1 Gene Is Associated With Alcohol Dependence
Batel P, et al.
Alcohol Clin Exp Res 2008 Mar

Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents
Desrivieres S, et al.
PLoS ONE 2008;3(3):e1769

 

Diseases of the Nervous System and Sense Organs

Synergistic effect of apolipoprotein E e4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
Lane R, et al.
Pharmacogenet Genomics 2008 Apr;18(4):289-98

Variants of RP1 gene in Chinese patients with autosomal dominant retinitis pigmentosa
Sheng X, et al.
Can J Ophthalmol 2008 Apr;43(2):208-12

Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study
Xing C, et al.
Genes Immun 2008 Mar

Increased CSF-BACE 1 activity is associated with ApoE-{varepsilon}4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
Ewers M, et al.
Brain 2008 Mar

Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism
Barnett JH, et al.
Biol Psychiatry 2008 Mar

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
Levinson RD, et al.
Genes Immun 2008 Mar

Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
Haugarvoll K, et al.
Neurology 2008 Mar

Multiple sclerosis and hepatitis C virus infection are associated with single nucleotide polymorphisms in interferon pathway genes
Fortunato G, et al.
J Interferon Cytokine Res 2008 Mar;28(3):141-52

An analysis of candidate autism loci on chromosome 2q24-q33: Evidence for association to the STK39 gene
Ramoz N, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease
Minster RL, et al.
Neurobiol Aging 2008 Mar

Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease
Lee JH, et al.
Neurogenetics 2008 Mar

Analysis of UBQLN1 Variants in a Polish Alzheimer's Disease Patient: Control Series
Golan MP, et al.
Dement Geriatr Cogn Disord 2008 Mar;25(4):366-71

Transcriptionally less active prodynorphin promoter alleles are associated with Temporal Lobe Epilepsy: A case-control study and meta-analysis
Kauffman MA, et al.
Dis Markers 2008;24(3):135-40

 

Diseases of the Circulatory System

Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid  haemorrhage in an Italian population
Fontanella M, et al.
J Neurol Neurosurg Psychiatry 2008 Apr;79(4):471-3

Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk?
Heil SG, et al.
Clin Chem Lab Med 2008 Mar

Association between PPAR-alpha gene polymorphisms and myocardial infarction
Reinhard W, et al.
Clin Sci (Lond) 2008 Mar

Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke
Kaplan RC, et al.
Atherosclerosis 2008 Mar

Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21
Matarin M, et al.
Stroke 2008 Mar

Genetic variants within the interleukin-1 gene cluster, and risk of incident myocardial infarction, and ischemic stroke: A nested case-control approach
Zee RY, et al.
Atherosclerosis 2008 Mar

Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or beta-blocker use and the risk of myocardial infarction and stroke
Schelleman H, et al.
Pharmacogenomics J 2008 Mar

C-338A polymorphism of the endothelin-converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery disease
Scacchi R, et al.
Dis Markers 2008;24(3):175-9

 

Diseases of the Respiratory System

Glutathione s-transferase p1, maternal smoking, and asthma in children: a haplotype-based analysis
Li YF, et al.
Environ Health Perspect 2008 Mar;116(3):409-15

ALOX5 promoter genotype and response to montelukast in moderate persistent asthma
Telleria JJ, et al.
Respir Med 2008 Mar

Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy
Wu H, et al.
Genes Immun 2008 Mar

Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms  on bronchial hyperresponsiveness in Korean children with asthma
Kim HB, et al.
Clin Exp Allergy 2008 Mar

 

Diseases of the Digestive System

Human leucocyte antigen and TNFalpha polymorphism association in microscopic colitis
Koskela RM, et al.
Eur J Gastroenterol Hepatol 2008 Apr;20(4):276-82

Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation
Rubio-Tapia A, et al.
Liver Int 2008 Apr;28(4):467-76

Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population
Tremelling M, et al.
Inflamm Bowel Dis 2008 Mar

Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis
Kotlowski R, et al.
Inflamm Bowel Dis 2008 Mar

The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease
Chernavsky AC, et al.
Cytokine 2008 Mar

The -308 TNFalpha Gene Polymorphism in Severe Acute Alcoholic Hepatitis: Identification of a New Susceptibility Marker
Nguyen-Khac E, et al.
Alcohol Clin Exp Res 2008 Mar

Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease
Osterreicher CH, et al.
Cytokine 2008 Mar

Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the finnish population
Lappalainen M, et al.
Inflamm Bowel Dis 2008 Mar

Mannan-binding lectin MBL2 gene polymorphism in chronic hepatitis C: association  with the severity of liver fibrosis and response to interferon therapy
Alves Pedroso ML, et al.
Clin Exp Immunol 2008 Mar

Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients
Umemura T, et al.
Am J Gastroenterol 2008 Mar;103(3):588-94

 

Diseases of the Genitourinary System

CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients
Hesselink DA, et al.
Pharmacogenet Genomics 2008 Apr;18(4):339-48

Iron indices and vitamin D receptor polymorphisms in hemodialysis patients
Amato M, et al.
Adv Chronic Kidney Dis 2008 Apr;15(2):186-90

Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
Crettol S, et al.
Pharmacogenet Genomics 2008 Apr;18(4):307-15

Influence of angiotensin I-converting enzyme polymorphism on development of post-transplant erythrocytosis in renal graft recipients
Kedzierska K, et al.
Clin Transplant 2008 Mar-2008 Apr;22(2):156-61

The value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection
Chin GK, et al.
Clin Exp Immunol 2008 Mar

Response to prednisone in relation to NR3C1 intron B polymorphisms in childhood nephrotic syndrome
Zalewski G, et al.
Pediatr Nephrol 2008 Mar

Genetic alterations of HOXA10 and their effect on the severity of endometriosis in a Taiwanese population
Wu HH, et al.
Reprod Biomed Online 2008 Mar;16(3):416-24

 

Complications of Pregnancy, Childbirth, and the Puerperium

Interleukin 6 -174 g/c promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1626 pregnant women
Stonek F, et al.
Am J Reprod Immunol 2008 Apr;59(4):347-51

 

Diseases of the Skin and Subcutaneous Tissue

Polymorphisms in the PTPN22 region are associated with psoriasis of early onset
Smith RL, et al.
Br J Dermatol 2008 Mar

 

Diseases of the Musculoskeletal System and Connective Tissue

Association of the 163A/G and 1181G/C Osteoprotegerin Polymorphism with Bone Mineral Density
Garcia-Unzueta MT, et al.
Horm Metab Res 2008 Mar;40(3):219-24

Identification of DIO2 as new susceptibility locus for symptomatic Osteoarthritis
Meulenbelt I, et al.
Hum Mol Genet 2008 Mar

Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
Dolman KM, et al.
Arthritis Res Ther 2008 Mar;10(2):R32

Osteopontin and systemic lupus erythematosus association: a probable gene-gender  interaction
Han S, et al.
PLoS ONE 2008;3(3):e0001757

 

Symptoms, Signs and Ill-defined Conditions

Doping Test Results Dependent on Genotype of UGT2B17, the Major Enzyme for Testosterone Glucuronidation
Schulze JJ, et al.
J Clin Endocrinol Metab 2008 Mar

Adaptation to high altitude in sherpas: association with the insertion/deletion polymorphism in the Angiotensin-converting enzyme gene
Droma Y, et al.
Wilderness Environ Med 2008 Spring;19(1):22-9

 

Injury and Poisoning

High arsenic metabolic efficiency in AS3MT287Thr allele carriers
Hernandez A, et al.
Pharmacogenet Genomics 2008 Apr;18(4):349-55

 

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Page last reviewed: March 20, 2008 (archived document)
Content Source: National Office of Public Health Genomics