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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 13, 2008
Volume 20, No. 11

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These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

The frequency of transforming growth factor-beta1 gene polymorphisms in a normal  southern Iranian population
Amani D, et al.
Int J Immunogenet 2008 Apr;35(2):145-51

 

Infectious and Parasitic Diseases

HLA-DQ3 is a probable risk factor for CMV infection in high-risk kidney transplant patients
Varga M, et al.
Nephrol Dial Transplant 2008 Mar

Distribution of HIV/AIDS associated CCR2-64allele of 14 Chinese ethnic populations in South China
Qian Y, et al.
Yi Chuan 2008 Mar;30(3):321-3

Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers
Deng G, et al.
Gastroenterology 2008 Mar;134(3):716-26.e2

Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women
Yasui Y, et al.
J Autoimmune Dis 2008 Mar;5(1):2

 

Neoplasms

COMT polymorphisms affecting protein expression are risk factors for endometrial  cancer
Hirata H, et al.
Mol Carcinog 2008 Mar

Comprehensive analysis of NuMA variation in breast cancer
Kilpivaara O, et al.
BMC Cancer 2008 Mar;8(1):71

XRCC1 and XRCC3 variants and risk of glioma and meningioma
Kiuru A, et al.
J Neurooncol 2008 Mar

Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?
Cardot-Bauters C, et al.
Clin Endocrinol (Oxf) 2008 Mar

Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India
Saxena A, et al.
World J Gastroenterol 2008 Mar;14(10):1498-503

Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis
Gorouhi F, et al.
Br J Cancer 2008 Mar

Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases  and the risk of esophageal squamous cell carcinoma in Gansu Chinese males
Guo YM, et al.
World J Gastroenterol 2008 Mar;14(9):1444-9

Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial
Murphy G, et al.
Cancer Causes Control 2008 Mar

Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk
Lee SA, et al.
Am J Clin Nutr 2008 Mar;87(3):753-60

Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer
Li H, et al.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 Mar;24(3):282-4

CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
Hirata H, et al.
Cancer 2008 Mar

Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Starke RM, et al.
J Cereb Blood Flow Metab 2008 Mar

 

Endocrine, Nutritional and Metabolic Diseases

Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men
Zhang L, et al.
Metabolism 2008 Apr;57(4):502-5

The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study
Henderson J, et al.
J Allergy Clin Immunol 2008 Mar

Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study
Gullstrand C, et al.
Pediatr Diabetes 2008 Mar

Common variants in MODY genes and future risk of type 2 diabetes
Holmkvist J, et al.
Diabetes 2008 Mar

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
Field SF, et al.
Diabetes 2008 Mar

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a  candidate gene for polycystic ovary syndrome
Goodarzi MO, et al.
Hum Reprod 2008 Mar

DRD4 48 bp VNTR but not 5-HT(2C) Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain
Popp J, et al.
Pharmacogenomics J 2008 Mar

Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes
Pedersen-Bjergaard U, et al.
Am J Med 2008 Mar;121(3):246.e1-8

A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM
Susa S, et al.
Biochem Biophys Res Commun 2008 Mar

Association study between PPARGC1A Thr394Thr/ Gly482Ser polymorphisms and type 2 diabetes
Su Y, et al.
Yi Chuan 2008 Mar;30(3):304-8

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients-the EUGENE2 study
Boesgaard TW, et al.
Diabetologia 2008 Mar

Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 (PD-L1) gene with Graves' disease in Japanese patients
Hayashi M, et al.
Eur J Endocrinol 2008 Mar

Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the  presence of population-specific effects: challenge for global health initiatives
Schwarz PE, et al.
Pharmacogenomics J 2008 Mar

Follicle-stimulating hormone receptor polymorphism (Thr(307)Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women
Achrekar SK, et al.
Fertil Steril 2008 Mar

 

Mental Disorders

Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients
Lotrich FE, et al.
J Psychiatry Neurosci 2008 Mar;33(2):123-30

Smoking status moderates the association of the dopamine D4 receptor (DRD4) gene  VNTR polymorphism with selective processing of smoking-related cues
Munafo MR & Johnstone EC
Addict Biol 2008 Mar

No Association of TPH1 218A/C Polymorphism with Treatment Response and Intolerance to SSRIs in Japanese Patients with Major Depression
Kato M, et al.
Neuropsychobiology 2008 Mar;56(4):167-71

Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan
Glatt SJ, et al.
Mol Psychiatry 2008 Mar

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia  in the Japanese population
Numata S, et al.
J Psychiatr Res 2008 Mar

Evidence that the COMT(Val158Met) polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia
van Winkel R, et al.
Eur Psychiatry 2008 Mar

A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
Ohtsuki T, et al.
Schizophr Res 2008 Mar

A regulatory variation in OPRK1, the gene encoding the {kappa}-opioid receptor, is associated with alcohol dependence
Edenberg HJ, et al.
Hum Mol Genet 2008 Mar

Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder
Adams DH, et al.
Hum Psychopharmacol 2008 Mar

 

Diseases of the Nervous System and Sense Organs

IL-1, IL-1R and TNFalpha Gene Polymorphisms in Iranian Patients with Multiple Sclerosis
Sarial S, et al.
Iran J Allergy Asthma Immunol 2008 Mar;7(1):37-40

Polymorphism in environment responsive genes and association with Parkinson disease
Singh M, et al.
Mol Cell Biochem 2008 Mar

ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease
Arning L, et al.
J Mol Med 2008 Mar

C3 R102G Polymorphism Increases Risk of Age-related Macular Degeneration
Spencer KL, et al.
Hum Mol Genet 2008 Mar

Apolipoprotein E epsilon4 Magnifies Lifestyle Risks for Dementia: A Population Based Study
Kivipelto M, et al.
J Cell Mol Med 2008 Mar

{alpha}-Synuclein, pesticides, and Parkinson disease. A case-control study
Brighina L, et al.
Neurology 2008 Mar

Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Kondo N, et al.
Invest Ophthalmol Vis Sci 2008 Mar;49(3):1101-5

14-3-3 Zeta and Tau Genes Interactively Decrease Alzheimer's Disease Risk
Mateo I, et al.
Dement Geriatr Cogn Disord 2008 Mar;25(4):317-20

HFE gene mutations in a population of Italian Parkinson's disease patients
Biasiotto G, et al.
Parkinsonism Relat Disord 2008 Mar

 

Diseases of the Circulatory System

A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction
Palacin M, et al.
Int J Immunogenet 2008 Apr;35(2):159-64

Genetic Variation in Members of the Leukotriene Biosynthesis Pathway Confer an Increased Risk of Ischemic Stroke. A Replication Study in Two Independent Populations
Bevan S, et al.
Stroke 2008 Mar

Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population
Linsel-Nitschke P, et al.
Clin Sci (Lond) 2008 Mar

Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With an Increased Risk of Ischemic Stroke in White Europeans
Gschwendtner A, et al.
Stroke 2008 Mar

The C(242)T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis
Di Castelnuovo A, et al.
Thromb Haemost 2008 Mar;99(3):594-601

Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study
He MA, et al.
Cell Stress Chaperones 2008 Mar

Genetic profile of ischemic cerebrovascular disease and carotid stenosis
Kostulas K, et al.
Acta Neurol Scand 2008 Mar

Promoter sequence variants of LIGHT are associated with female vascular dementia
Kong M, et al.
J Biomed Sci 2008 Mar

Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes
Costacou T, et al.
Diabetes 2008 Mar

Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population - results from the HUNT 2 study
Naess IA, et al.
Br J Haematol 2008 Mar

A Novel Zip2 Gln/Arg/Leu Codon 2 Polymorphism Is Associated with Carotid Artery Disease in Aging
Giacconi R, et al.
Rejuvenation Res 2008 Mar

Polymorphisms of the Tumor Suppressor Gene LSAMP are Associated with Left Main Coronary Artery Disease
Wang L, et al.
Ann Hum Genet 2008 Mar

Genetic Variation of the Androgen Receptor and Risk of Myocardial Infarction and  Ischemic Stroke in Women
Rexrode KM, et al.
Stroke 2008 Mar

Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation
Pacanowski MA, et al.
J Transl Med 2008 Mar;6(1):11

Fibrinogen gene variation and ischemic stroke
Jood K, et al.
J Thromb Haemost 2008 Mar

Variants of the Interferon Regulatory Factor 5 Gene Regulate Expression of IRF5 mRNA in Atherosclerotic Tissue but Are Not Associated With Myocardial Infarction
Malarstig A, et al.
Arterioscler Thromb Vasc Biol 2008 Mar

 

Diseases of the Digestive System

Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method
Komatsu Y, et al.
Int J Immunogenet 2008 Apr;35(2):165-70

Difference in apolipoprotein E type 4 allele (APOE epsilon4) among dentate and edentulous subjects
Bergdahl M, et al.
Gerodontology 2008 Mar

NAT1 Genotypes Do not Predict Response to Mesalamine in Patients with Ulcerative  Colitis
Hausmann M, et al.
Z Gastroenterol 2008 Mar;46(3):259-65

Candidate genotypes associated with functional dyspepsia
van Lelyveld N, et al.
Neurogastroenterol Motil 2008 Mar

 

Diseases of the Genitourinary System

Endothelial nitric oxide synthase polymorphisms are associated with hypertension  and cardiovascular disease in renal transplantation
Bhandary UV, et al.
Nephrology (Carlton) 2008 Mar

Do we need to search for gr/gr deletions in infertile men in a clinical setting?
Stouffs K, et al.
Hum Reprod 2008 Mar

 

Complications of Pregnancy, Childbirth, and the Puerperium

Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
Tsai HJ, et al.
Hum Genet 2008 Mar

 

Diseases of the Skin and Subcutaneous Tissue

Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris
Li H, et al.
Arch Dermatol Res 2008 Mar

 

Diseases of the Musculoskeletal System and Connective Tissue

Common Polymorphisms in the Folate Pathway Predict Efficacy of Combination Regimens Containing Methotrexate and Sulfasalazine in Early Rheumatoid Arthritis
James HM, et al.
J Rheumatol 2008 Mar

Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis
Nicknam MH, et al.
Iran J Allergy Asthma Immunol 2008 Mar;7(1):19-24

Association of the HLA-G 14-bp insertion/deletion polymorphism with juvenile idiopathic arthritis and rheumatoid arthritis
Veit TD, et al.
Tissue Antigens 2008 Mar

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese
Mototani H, et al.
Hum Mol Genet 2008 Mar

Osteoprotegerin Lys3Asn Polymorphism and the Risk of Fracture in Older Women
Moffett SP, et al.
J Clin Endocrinol Metab 2008 Mar

 

Symptoms, Signs and Ill-defined Conditions

Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF
Gremlich S, et al.
Hum Reprod 2008 Mar

 

 

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Page last reviewed: March 13, 2008 (archived document)
Content Source: National Office of Public Health Genomics