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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 6, 2008
Volume 20, No. 10

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

Distribution of ABCB1 polymorphisms among Brazilians: impact of population admixture
Estrela RC, et al.
Pharmacogenomics 2008 Mar;9(3):267-76

Distribution of HFE gene mutations in Slovenian patients with hereditary hemochromatosis
Stepec S, et al.
Ann Hematol 2008 Mar

 

Infectious and Parasitic Diseases

Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals
Boulet S, et al.
AIDS 2008 Mar;22(5):595-9

Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection
Cheong JY, et al.
J Korean Med Sci 2008 Feb;23(1):61-5

 

Neoplasms

Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients
Vaclavikova R, et al.
Pharmacogenet Genomics 2008 Mar;18(3):263-73

Analysis of the ERalpha germline PvuII marker in breast cancer risk
Gonzalez-Mancha R, et al.
Med Sci Monit 2008 Mar;14(3):CR136-43

Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
Rudin CM, et al.
J Clin Oncol 2008 Mar;26(7):1119-27

Genetic variants of the cytochrome P450 and glutathione S-transferase associated  with risk of bladder cancer in a south-eastern Chinese population
Shao J, et al.
Int J Urol 2008 Mar;15(3):216-21

RANTES-403 polymorphism is associated with reduced risk of gastric cancer in women
Liou JM, et al.
J Gastroenterol 2008 Feb;43(2):115-23

Association of HLA alleles with non-Hodgkin's lymphoma in Korean population
Choi HB, et al.
Int J Hematol 2008 Feb

The role of CYP2D6*4 variant in bladder cancer susceptibility in Tunisian patients
Ouerhani S, et al.
Bull Cancer 2008 Feb;95(2):E1-4

Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study
Agalliu I, et al.
Prostate 2008 Feb

Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma
Farhat K, et al.
Int J Immunogenet 2008 Feb

Polymorphisms of GSTM1 and CYP1A1 genes and their genetic susceptibility to prostate cancer in Chinese men
Li M, et al.
Chin Med J (Engl) 2008 Feb;121(4):305-8

 

Endocrine, Nutritional and Metabolic Diseases

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels and Resting Metabolic Rate in the Quebec Family Study
Do R, et al.
Diabetes 2008 Mar

NYD-SP18 is associated with obesity in the NHLBI Family Heart Study
Wilk JB, et al.
Int J Obes (Lond) 2008 Mar

Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
Vella A, et al.
Diabetologia 2008 Mar

Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility
Simoni M, et al.
Pharmacogenet Genomics 2008 Mar;18(3):193-200

AHSG tagSNPs associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 Danish whites
Andersen G, et al.
Diabetes 2008 Mar

Body Mass Index is Associated with USF1 Haplotype in Korean Premenopausal Women
Lee SK, et al.
J Korean Med Sci 2008 Feb;23(1):83-8

Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population
Kim YS, et al.
Yonsei Med J 2008 Feb;49(1):58-62

Association of 5-HTT gene polymorphism, platelet MAO activity, and drive for thinness in a population-based sample of adolescent girls
Akkermann K, et al.
Int J Eat Disord 2008 Feb

Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
Kolz M, et al.
BMC Med Genet 2008 Feb;9(1):9

Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
Keene KL, et al.
Hum Genet 2008 Feb

 

Mental Disorders

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
Hennah W, et al.
Mol Psychiatry 2008 Mar

Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial
Lavedan C, et al.
Pharmacogenomics 2008 Mar;9(3):289-301

Association of PIP5K2A with schizophrenia: A study in an indonesian family sample
Saggers-Gray L, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypes
Peters K, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function
Smoller JW, et al.
Arch Gen Psychiatry 2008 Mar;65(3):298-308

Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder
Pickard BS, et al.
Mol Psychiatry 2008 Mar

Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs)
Nose J, et al.
J Hum Genet 2008 Mar

Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral results
Wong WM, et al.
Pharmacopsychiatry 2008 Mar;41(2):72-8

Possible association of the alpha-2A-adrenergic receptor gene with response time  variability in attention deficit hyperactivity disorder
Cho SC, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Mar

Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety
Childs E, et al.
Neuropsychopharmacology 2008 Feb

COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study
Hagen K, et al.
Pharmacoepidemiol Drug Saf 2008 Feb

Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Joe KH, et al.
Biochem Biophys Res Commun 2008 Feb

The -1019 C/G polymorphism of the 5-HT1A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients
Wang L, et al.
J Psychopharmacol 2008 Feb

 

Diseases of the Nervous System and Sense Organs

Apolipoprotein E gene polymorphism and the risk of cervical myelopathy in patients with chronic spinal cord compression
Setzer M, et al.
Spine 2008 Mar;33(5):497-502

Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
Halling J, et al.
Pharmacogenet Genomics 2008 Mar;18(3):209-12

Reappraisal of the role of the DRD3 gene in essential tremor
Blair MA, et al.
Parkinsonism Relat Disord 2008 Mar

C677T Methylene-H4-Folate-Reductase Variant Decreases Binocular Accommodation
Krumdieck CL, et al.
Optom Vis Sci 2008 Mar;85(3):196-200

HTRA1 Variants in Exudative Age-related Macular Degeneration and Interactions with Smoking and CFH
Tam PO, et al.
Invest Ophthalmol Vis Sci 2008 Mar

Essential tremor and the common LRRK2 G2385R variant
Tan EK, et al.
Parkinsonism Relat Disord 2008 Mar

Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer's  disease risk
Combarros O, et al.
J Neural Transm 2008 Feb

Cluster Analysis of Risk Factor Genetic Polymorphisms in Alzheimer's Disease
Randall CN, et al.
Neurochem Res 2008 Feb

Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E varepsilon4 allele
Pinhel MA, et al.
Clin Chem Lab Med 2008 Feb

 

Diseases of the Circulatory System

Association of deoxyribonuclease I genetic polymorphisms with myocardial infarction in Han Chinese
Ni Y & Zhang J
Mol Biol Rep 2008 Mar

Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome
Schwartz PJ, et al.
J Am Coll Cardiol 2008 Mar;51(9):920-9

Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension
Oniki K, et al.
Pharmacogenet Genomics 2008 Mar;18(3):275-7

Haplotype of the angiotensinogen gene is associated with coronary heart disease in familial hypercholesterolemia
van der Net JB, et al.
J Hypertens 2008 Mar;26(3):462-7

Haplotype analysis revealed a genetic influence of osteopontin on large artery atherosclerosis
Kim Y & Lee C
J Biomed Sci 2008 Mar

Gain of function in I(Ks) secondary to a mutation in KCNE5 associated with atrial fibrillation
Ravn LS, et al.
Heart Rhythm 2008 Mar;5(3):427-35

Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow
Nurkalem Z, et al.
Coron Artery Dis 2008 Mar;19(2):85-8

A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men
Fu Z, et al.
J Hypertens 2008 Mar;26(3):453-61

Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease
Sarecka B, et al.
Clin Biochem 2008 Feb

Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis
Abboud S, et al.
Eur J Hum Genet 2008 Feb

Variation in the Estrogen Receptor {alpha} Gene and Risk of Stroke. The Rotterdam Study
Bos MJ, et al.
Stroke 2008 Feb

 

Diseases of the Respiratory System

Distinct association of genetic variations of vascular endothelial growth factor, transforming growth factor-beta, and fibroblast growth factor receptors with atopy and airway hyperresponsiveness
Park HK, et al.
Allergy 2008 Apr;63(4):447-53

Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in  Tunisian children
Lachheb J, et al.
Tissue Antigens 2008 Feb

Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults
Basu K, et al.
Allergy 2008 Feb

 

Diseases of the Digestive System

Interleukin-1 Gene Polymorphism, Diabetes, and Periodontitis: Results From the Study of Health in Pomerania (SHIP)
Struch F, et al.
J Periodontol 2008 Mar;79(3):501-7

Local Expression of Interleukin-10 and mCD14 in Relation to the -1087 IL-10 and -159 CD14 Gene Polymorphisms in Chronic Periodontitis
Donati M, et al.
J Periodontol 2008 Mar;79(3):517-24

T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion
Szoke D, et al.
Eur J Gastroenterol Hepatol 2008 Mar;20(3):191-5

Cholesterol 7alpha-Hydrolase (CYP7A1) c.-278A>C Promoter Polymorphism in Gallstone Disease Patients
Juzyszyn Z, et al.
Genet Test 2008 Feb

 

Diseases of the Genitourinary System

The GLUT-1 XbaI Gene Polymorphism Is Associated with Vascular Calcifications in Nondiabetic Uremic Patients
Rufino M, et al.
Nephron Clin Pract 2008 Mar;108(3):c182-c187

Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated  in endometriosis progression
Borghese B, et al.
Hum Reprod 2008 Feb

Association of Androgen Receptor CAG Repeat Polymorphism and Polycystic Ovary Syndrome
Shah NA, et al.
J Clin Endocrinol Metab 2008 Feb

 

Diseases of the Musculoskeletal System and Connective Tissue

Molecular aspects of osteopathy in type 1 Gaucher disease: correlation between genetics and bone density
Arnheim E, et al.
Rheumatol Int 2008 Mar

New classification of HLA-DRB1 alleles in Rheumatoid Arthritis susceptibility: a  combined analysis of worldwide samples
Barnetche T, et al.
Arthritis Res Ther 2008 Feb;10(1):R26

Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population
Lee HJ, et al.
Rheumatol Int 2008 Feb

Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFalpha therapy in rheumatoid arthritis?
Ongaro A, et al.
Rheumatol Int 2008 Feb

Vitamin D Receptor Genotype is Associated with Falls Among Older Adults Living in the Community: Results from the ilSIRENTE Study
Onder G, et al.
J Bone Miner Res 2008 Feb

 

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Page last reviewed: March 6, 2008 (archived document)
Content Source: National Office of Public Health Genomics